The Relationship between the Level of the Pregnancy Associated Plasma Protein-A (PAPP-A) and Some Reproductive Hormones in Serum of Iraqi Women Undergoing ICSI Protocol

Abstract

Background: Pregnancy Associated Placental Protein-A (PAPP-A) is a zinc-binding metalloproteinase with a key role in the insulin-like growth factor (IGF) pathway. The IGF system plays an essential role in follicular development, including steroid hormone synthesis, growth, recruitment, and apoptosis of follicles of women undergoing intracytoplasmic sperm injection (ICSI). Objective: The objective of this study is to measure Pregnancy Associated Plasma Protein-A (PAPP-A) in serum of infertile women undergoing ICSI, and to investigate the association of PAPP-A with some reproductive hormones level. A total of 45 infertile women. Results:The results of this study was Serum PAPP-A level was not significant with hormones level (FSH, LH PRO and AMH) except E2 hormone was significant. Conclusion: Outcome show that no relation between studied reproductive hormones and serum PAPP-A except E2 levels that are high cause the egg to mature and release from the ovary.