The relationship between the micro-mechanism and macroscopic dielectric properties in Ba 1−x Bi x Ti 1−x−y Zn 0.75x W 0.25x+y O 3+y systems

Zhang, Bowen; Li, Lingxia

doi:10.1016/j.ceramint.2016.05.049

Cited by 10 publications

(15 citation statements)

References 42 publications

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“…Elevated expression and activation of GSK‐3β has been reported in AD brains, which augments Aβ production by enhancing the transcription of amyloid cascade proteins including APP and PS1 (Figure e) . Curcumin has been reported to downregulate GSK‐3β expression and directly bind Aβ oligomers to inhibit its toxicity which was also demonstrated in vitro (Fig c). Thus, we suggested curcumin could restrain Aβ‐induced microglia activation from both a biochemical level via Aβ inhibition and a transcriptional level by interrupting GSK‐3β pathway in neurons.…”

Section: Resultsmentioning

confidence: 72%

“…As shown in Figure 5f and Figure S17 in the Supporting Information, we found significantly inhibited glycogen synthase kinase-3β (GSK-3β) expression and decreased APP, PS1 (γ-secretase) mRNA expression in the brain of APLB/CUR treated mice. [42] Curcumin has been reported to downregulate GSK-3β expression [43] and directly bind Aβ oligomers to inhibit its toxicity which was also demonstrated in vitro (Fig 3c). [42] Curcumin has been reported to downregulate GSK-3β expression [43] and directly bind Aβ oligomers to inhibit its toxicity which was also demonstrated in vitro (Fig 3c).…”

Section: Monitoring Of Brain Microenvironment Changes During Treatmenmentioning

confidence: 92%

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Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia

et al. 2018

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Current strategies for Alzheimer's disease (AD) treatments focus on pathologies in the late stage of the disease progression. Poor clinical outcomes are displayed due to the irreversible damages caused by early microglia abnormality which triggers disease development before identical symptoms emerge. Based on the crosstalk between microglia and brain microenvironment, a reactive oxygen species (ROS)‐responsive polymeric micelle system (Ab‐PEG‐LysB/curcumin (APLB/CUR)) is reported to normalize the oxidative and inflammatory microenvironment and reeducate microglia from an early phase of AD. Through an β‐amyloid (Aβ) transportation‐mimicked pathway, the micelles can accumulate into the diseased regions and exert synergistic effects of polymer‐based ROS scavenging and cargo‐based Aβ inhibition upon microenvironment stimuli. This multitarget strategy exhibits gradual correction of the brain microenvironment, efficient neuroprotection, and microglia modulation, leading to decreased Aβ plaque burdens and consequently enhanced cognitive functions in APPswe/PSEN1dE9 model mice. The results indicate that microglia can be exploited as an early target for AD treatment and their states can be controlled via microenvironment modulation.

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Section: Resultsmentioning

confidence: 72%

Section: Monitoring Of Brain Microenvironment Changes During Treatmenmentioning

confidence: 92%

Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia

et al. 2018

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“…During the last years, a large amount of observational data provided a better and much more detailed picture of these active galaxies (see, e.g. Barth et al 2002;Costamante & Ghisellini 2002;Falomo et al 2002;Vagnetti et al 2003) and also (Falcone et al 2004;Bramel et al 2005;Nieppola et al 2006;Zheng et al 2007). Therefore, all these observational data make the theoretical study of active galaxies hosting BL Lacs both interesting and challenging task.…”

Section: Discussionmentioning

confidence: 99%

Determining the nature of orbits in a three‐dimensional galaxy model hosting a BL Lacertae object

Zotos

2014

Astron Nachr

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A three-dimensional dynamical model for a galaxy hosting a BL Lacertae object is constructed. The model consists of a logarithmic potential representing an elliptical host galaxy with a bulge of radius c b and a dense massive nucleus. Using numerical experiments, we try to distinguish between regular and chaotic motion in both 2D and 3D system. In particular, we investigate how the basic parameters of our model, such as the mass of the nucleus, the internal perturbation and the flattening parameters influence the amount and the degree of chaos. Interesting correlations are presented for both 2D and 3D dynamical models. Our numerical results are explained and supported using elementary theoretical arguments and analytical calculations. Of particular interest, is the local integral of motion which have been found to exist in the vicinity of stable periodic points. The obtained numerical outcomes of the present research, are linked and also compared with several data derived from observations.

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“…The method calculates the compressive strength of wood. 48,49 This paper refers to the "Wooden Structure Design Manual", 50 takes the 0.05 quantile value of the probability distribution, and calculates the standard value of the compressive strength of the reconstituted bamboo. According to the standard value of compressive strength, the design value of the compressive strength of reconstituted bamboo was further obtained.…”

Section: Determination Methods Of the Design Value Of The Compressive...mentioning

confidence: 99%

Effect of temperature on compressive mechanical properties and strength design index of reconstituted bamboo

Zhao

Wei

Chen

et al. 2022

J of Applied Polymer Sci

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The effect of temperature on the compressive properties of recombinant bamboo was analyzed. At different temperatures (10 $ 70 C), the failure mode, basic mechanical properties, stress-strain model, and design value of the compressive strength of hot-pressed reconstituted bamboo were investigated through axial unidirectional compression tests. The results indicate that with a rise in temperature, the reconstituted bamboo material changes from brittle to ductile, showing three failure modes: splitting failure, shear failure, and buckling cracking failure. The ultimate compressive strength of reconstituted bamboo decreased from 79.96 to 40.81 MPa, a decrease of 48.96%, and the compressive strain of reconstituted bamboo increased from 0.0069 to 0.0120, an increase of 72.16%. Based on the Richard-Abbott model, the function relation between the elastic modulus reduction factor (λ E1,T ) and the post-yield modulus reduction factor (λ E2,T ) of bamboo compression specimens and the temperature were obtained. A model of the design value of the compression strength considering temperature was established, and the design value of the compression strength was evaluated.

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The relationship between the micro-mechanism and macroscopic dielectric properties in Ba 1−x Bi x Ti 1−x−y Zn 0.75x W 0.25x+y O 3+y systems

Cited by 10 publications

References 42 publications

Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia

Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia

Determining the nature of orbits in a three‐dimensional galaxy model hosting a BL Lacertae object

Effect of temperature on compressive mechanical properties and strength design index of reconstituted bamboo

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