The Relationship between the Plasma PCSK9 Levels and Platelet Indices in Patients with Stable Coronary Artery Disease

Li, Sha; Zhu, Cheng‐Gang; Guo, Yuan‐Lin; Xu, Rui‐Xia; Zhang, Yan; Sun, Jing; Li, Jianjun

doi:10.5551/jat.25841

Cited by 49 publications

(37 citation statements)

References 23 publications

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“…In our initial search, 26 studies were found and we limited the analysis to those with subjects aged at least 18 years and acute medical process or intervention without a ‘baseline' plasma draw. This eliminated 11 studies, leaving 15 for analysis [10,11,12,13,14,15,16,17,18,19,20,21,22]. Pooled medians were reported with 95% confidence intervals.…”

Section: Methodsmentioning

confidence: 99%

Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis

Boyd¹,

Fjell²,

Russell³

et al. 2016

J Innate Immun

118

110

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Purpose: We have recently shown that PCSK9 reduces the clearance of endotoxin and is therefore a critical regulator of the innate immune response during infection. However, plasma PCSK9 levels during human sepsis and their relationship to outcomes are not known. Our objective was to determine the relationship between plasma PCSK9 levels and the rate of endotoxin clearance, and then correlate PCSK9 levels with the development of acute organ failures in a cohort of patients with sepsis. Methods: Using human hepatocyte cells, we determined the threshold at which PCSK9 is able to reduce Escherichia coli endotoxin uptake by cultured human hepatocytes. In a single-centre observational cohort at St. Paul's Hospital in Vancouver, Canada, we recruited 200 patients who activated our Emergency Department's sepsis protocol and measured plasma PCSK9 and lipid levels at triage and throughout the admission. Outcomes were the development of sepsis-induced cardiovascular or respiratory failure. Results: We reviewed the literature and determined that the normal human range of PCSK9 found in plasma is 170-220 ng/ml, while levels of 250 ng/ml and above reduced E. coli endotoxin clearance in cultured human hepatocytes. In septic patients, the median levels associated with new-onset respiratory and cardiovascular failure were 370 (250-500) and 380 (270-530) ng/ml, respectively, versus 270 (220-380) ng/ml in patients who did not go on to develop any organ failure (p = 0.003 and 0.005, respectively). Conclusions: Plasma PCSK9 levels are greatly increased in sepsis. At normal levels, PCSK9 has no influence upon hepatocyte bacterial endotoxin clearance, but as levels rise, there is a progressive inhibition of clearance. During sepsis, PCSK9 levels are highly correlated with the development of subsequent multiple organ failure. Inhibition of PCSK9 activity is an attractive target for treating the spectrum of sepsis and septic shock.

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Section: Methodsmentioning

confidence: 99%

Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis

Boyd¹,

Fjell²,

Russell³

et al. 2016

J Innate Immun

118

110

View full text Add to dashboard Cite

show abstract

“…[5] The association of increased MPV, PDW, P-LCR, and platelet count with diseases related to endothelial dysfunction such as metabolic syndrome, diabetes, coronary artery disease (CAD), and malignancy has been shown in many studies. [6,7,8,9] The newer hematological analyzers are giving variety of platelet parameters which helps in easy detection of change in platelet structure, which may help in early detection of prothrombotic state of the platelets. These can act as an alarm for diagnosing initiation/progression of diabetic complications.…”

Section: Introductionmentioning

confidence: 99%

An Evaluation study of Platelet Volume Indices (PVI) in Type-2 Diabetes Mellitus and its Micro and Macro Vascular Complications

Desai¹,

Lakum

2018

APALM

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Background:The study was performed to analyse PVI such as mean platelet volume (MPV), platelet distribution width (PDW) and plateletlarge cell ratio (P-LCR) that are useful for identifying large and haemostatically active platelets, which are risk factors for developing diabetes and its complication.Methods: Case-control study was conducted on 1026 Type 2 diabetics and 616 nondiabetics. Detailed clinical history regarding duration, hypertension and complications was taken. PVI was obtained using three part automated cell counter. Fasting blood glucose, hemoglobin A1C, lipid profile, creatinine were also obtained. Diabetics were further categorized into patients with complications and without complications.Result: MPV, PDW, P-LCR and platelet count were significantly increased in diabetic patients with complications as compared to diabetics without complications and nondiabetic group (P < 0.0001, < 0.0001, 0.0044, 0.023 respectively). We found statistically significant correlation between MPV and diabetic retinopathy (P < 0.0001), nephropathy (P = 0.04), neuropathy (P < 0.0001), coronary artery disease (P < 0.0001), diabetic foot (P = 0.005). PDW was statistically significantly increased in diabetic retinopathy (P < 0.0001), neuropathy (P < 0.0001), coronary artery disease (P < 0.0001), diabetic foot (P = 0.005). P-LCR was statistically significantly increased in diabetic retinopathy (P < 0.0001), neuropathy (P = 0.003), coronary artery disease (P < 0.0001), diabetic foot (P = 0.034). Conclusion:MPV, PDW and P-LCR are predictive biomarkers of diabetic vascular complications. They are more significant in microvascular complications than macrovascular complications.

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“…Platelets are a central element of the athero-thrombotic process due to their prothrombotic and proinflamatory function [8,9,10]. The association of increased MPV, PDW and decreased platelet count with disease related to endothelial dysfunction such as metabolic syndrome diabetes, coronary artery disease (CAD) and malignancy which has been shown in many studies [11][12][13][14][15]. Diabetes particularly DMT2 patients are exposed to the increased platelet reactivity due to multi factorial causes such as metabolic (e.g hyperglycemia, hypertriglyceridemia) and systemic abnormalities (eg.…”

Section: Introductionmentioning

confidence: 99%

Association of Mean Platelet Volume and Platelet Distribution Width with Hba1c

Jaman¹

2017

JED

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The Relationship between the Plasma PCSK9 Levels and Platelet Indices in Patients with Stable Coronary Artery Disease

Cited by 49 publications

References 23 publications

Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis

Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis

An Evaluation study of Platelet Volume Indices (PVI) in Type-2 Diabetes Mellitus and its Micro and Macro Vascular Complications

Association of Mean Platelet Volume and Platelet Distribution Width with Hba1c

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