2019
DOI: 10.3390/medicina55100706
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The Relationship between the Soluble Receptor for Advanced Glycation End Products and Oxidative Stress in Patients with Palmoplantar Warts

Abstract: Background and objectives: Warts are the most common lesions caused by human papillomavirus (HPV). Recent research suggests that oxidative stress and inflammation are involved in the pathogenesis of HPV-related lesions. It has been shown that the soluble receptor for advanced glycation end products (sRAGE) may act as a protective factor against the deleterious effects of inflammation and oxidative stress, two interconnected processes. However, in HPV infection, the role of sRAGE, constitutively expressed in th… Show more

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Cited by 9 publications
(14 citation statements)
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“…An AGER1 membrane protein has recently been described that, in conjunction with sRAGE, attenuates the harmful effects of RAGE activation by modulating the absorption, degradation, and elimination of AGE and suppressing the inflammation and oxidative stress generated by RAGE [ 46 ]. sRAGE could interact with ligands, but AGE–RAGE activation is blocked [ 46 , 47 ].…”
Section: Discussionmentioning
confidence: 99%
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“…An AGER1 membrane protein has recently been described that, in conjunction with sRAGE, attenuates the harmful effects of RAGE activation by modulating the absorption, degradation, and elimination of AGE and suppressing the inflammation and oxidative stress generated by RAGE [ 46 ]. sRAGE could interact with ligands, but AGE–RAGE activation is blocked [ 46 , 47 ].…”
Section: Discussionmentioning
confidence: 99%
“…The receptor for advanced glycation end products (RAGE) is a multi-ligand cell surface protein [ 42 , 43 ]. AGE binding to RAGE-specific receptors, expressed on the renal, endothelial, immune, and inflammatory cells membrane, releases profibrogenic and proinflammatory cytokines, generates intracellular hydrogen peroxide and oxygen, and inhibits nitric oxide production [ 44 , 45 , 46 , 47 ]. The physiopathological role of RAGE signaling was demonstrated in many inflammatory and malignant disorders.…”
Section: Introductionmentioning
confidence: 99%
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“…The beta genus comprises 5 species with cutaneous tropism including HPV 5 and 8 also known as epidermodysplasia verruciformis (EV) types, being classically reported in patients with EV. The genera gamma, mu, and nu exhibit skin tropism and cause warts [19][20][21][22]. Thus, based on their tropism, HPV types can be divided into 2 main groups, cutaneous and mucosal HPV types [23].…”
Section: Classification Of Hpv Typesmentioning
confidence: 99%
“…In SLE, oxidative stress is involved in the formation of advanced glycation end products (AGEs) and advanced lipoperoxidation end products (ALEs), compounds with proinflammatory characteristics. AGEs and ALEs synthesis is realized through condensation reactions between electrophile and nucleophile reactants [ 17 , 21 , 22 , 23 , 24 , 25 ]. AGEs and ALEs are immunogen and they determine antibodies synthesis.…”
Section: Introductionmentioning
confidence: 99%