The relationship between thrombophilic mutations and preeclampsia: a prospective case-control study

Abstract

BACKGROUNDPreeclampsia and its association with thrombophilia remain controversial, due to inconsistent results in different studies, which include different ethnic groups, selection criteria, and patient numbers. The aim of this study was to determine the relationship between thrombophilia and preeclamptic patients in our region.METHODSIn a prospective case-control study, we compared 100 consecutive women with preeclampsia and eclampsia (group 1) with 100 normal pregnant women (group 2). All women were tested two months after delivery for mutations of factor V Leiden, methylenetetrahydrofolate reductase (MTHFR), and prothrombin gene mutation as well as for deficiencies of protein C, protein S, and antithrombin III.RESULTSA thrombophilic mutation was found in 42 (42%) and 28 (28%) women in group 1 and group 2, respectively (P=0.27, OR 1.5, 95%CI 1.0–2.2). The incidence of Factor V Leiden mutation (heterozygous), prothrombin mutation (heterozygous), prothrombin mutation (homozygous), MTHFR mutation (homozygous) was not statistically significant in group 1 compared with group 2 (P>0.05). Also, deficiencies of protein S, protein C, and antithrombin III were not statistically significant in group 1 compared with group 2 (P >0.05).CONCLUSIONThere was no difference in thrombophilic mutations between preeclamptic patients and normal pregnant women in our region. Therefore, we suggest that preeclamptic patients should not be tested for thrombophilia.

Associations of MTHFR Gene Polymorphisms with Hypertension and Hypertension in Pregnancy: A Meta-Analysis from 114 Studies with 15411 Cases and 21970 Controls

“…Among all studies, 42 studies were performed among East Asians [27], [28], [33], [37], [42], [43], [48], [50], [54], [56], [57], [60], [65], [73], [75], [78], [79], [81], [86]–[90], [94]–[97], [102], [103], [105]–[107], [115]–[118], [122], [124], [131], [132], [134], [136], 54 among Caucasians [29], [31], [32], [34], [35], [38]–[41], [44]–[47], [49], [51]–[53], [55], [59], [63], [64], [66], [67], [69]–[72], [74], [76], [77], [80], [82], [84], [92], [93], [98]–[101], [109], [110], [112]–…”

Associations between pre‐eclampsia and protein C and protein S levels among pregnant Nigerian women

“…However, similar studies have not found a significant difference in mean levels of free protein S between the study groups, 2,20,21 probably because of differences in the study participants, in the period of sample collection, and in the assay methods. For example, Yalinkaya et al 21 analyzed samples collected during the postpartum period (8 weeks) and used a coagulation-based assay. The expected changes in the levels of these proteins, owing to the effects of pregnancy and pre-eclampsia, might have almost completely resolved by this stage.…”

Association of hypertensive disorders of pregnancy risk and factor V Leiden mutation: A meta‐analysis

“…This mutation may result in thrombus formation in the placenta and thus may be a genetic risk factor for preeclampsia. 18,63,[66][67][68][69] However, many studies have controversial results about whether the FVL mutation is a genetic factor that involved in the development of HDP. For example, among all the studies in this meta-analysis, 15 of them get a negative result (GA + AA/GG, OR < 1.5) that the FVL mutation is not an important genetic involvement of HDP, 35 of them have the positive conclusion (GA + AA/GG, OR ≥ 1.5).…”