The Relationship Between Trauma Exposure and Obsessive–Compulsive Disorder in Youth: A Systematic Review

Wislocki, Katherine; Kratz, Hilary E.; Martin, Gerald J; Becker‐Haimes, Emily M.

doi:10.1007/s10578-022-01352-5

Cited by 5 publications

(3 citation statements)

References 90 publications

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“…In this case, too, the available evidence suggests that at least some types of OCD have developmental antecedents. The evidence for these developmental alterations has been summarized in recent reviews (Poletti et al, 2022a ) and includes altered cortical and white matter development in early-onset OCD (Li et al, 2021 ; Park et al, 2022 ), functional alterations in cortico-striato-thalamic circuits in childhood OCD (Huyser et al, 2009 ; Liu et al, 2016 ), a higher frequency of neurological soft signs in OCD patients with poor insight or comorbid tics (Karadag et al, 2011 ; Ekinci and Ekinci, 2020 ), subtle alterations in facial morphology in early-onset OCD (Wang et al, 2021 ), and associations between OCD and events that could alter brain development either pre- or perinatally (Vasconcelos et al, 2007 ) or in early childhood (Barzilay et al, 2019 ; Wislocki et al, 2022 ).…”

Section: Neurodevelopment and Ocd In Humansmentioning

confidence: 99%

SAPAP3, SPRED2, and obsessive-compulsive disorder: the search for fundamental phenotypes

Rajkumar

2023

Front. Mol. Neurosci.

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Section: Neurodevelopment and Ocd In Humansmentioning

confidence: 99%

SAPAP3, SPRED2, and obsessive-compulsive disorder: the search for fundamental phenotypes

Rajkumar

2023

Front. Mol. Neurosci.

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“…With specific regard to the pediatric population, a possible link between OCD and trauma is even less clear. Vazequez et al 2022 [36] have found that a history of trauma would not exert a significant impact on the severity of the disorder, whereas a recent systematic review [37] showed mixed findings on this topic , arguing for more knowledge on this age group.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Childhood Trauma Experiences and Psychotic Vulnerability in Obsessive Compulsive Disorder: An Italian Cross-Sectional Study

Borrelli,

Dell’Uva,

Provettini

et al. 2024

Brain Sciences

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People with obsessive compulsive disorder (OCD) are at increased risk of developing psychotic disorders; yet little is known about specific clinical features which might hint at this vulnerability. The present study was aimed at elucidating the pathophysiological mechanism linking OCD to psychosis through the investigation of childhood trauma experiences in adolescents and adults with OCD. One hundred outpatients, aged between 12 and 65 years old, were administered the Yale–Brown Obsessive Compulsive Scale (Y-BOCS) and its Child version (CY-BOCS), as well as the Childhood Trauma Questionnaire (CTQ); Cognitive–Perceptual basic symptoms (COPER) and high-risk criterion Cognitive Disturbances (COGDIS) were assessed in the study sample. Greater childhood trauma experiences were found to predict psychotic vulnerability (p = 0.018), as well as more severe OCD symptoms (p = 0.010) and an earlier age of OCD onset (p = 0.050). Participants with psychotic vulnerability reported higher scores on childhood trauma experiences (p = 0.02), specifically in the emotional neglect domain (p = 0.01). In turn, emotional neglect and psychotic vulnerability were found higher in the pediatric group than in the adult group (p = 0.01). Our findings suggest that childhood trauma in people with OCD may represent an indicator of psychotic vulnerability, especially in those with an earlier OCD onset. Research on the pathogenic pathways linking trauma, OCD, and psychosis is needed.

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“…These studies revealed that orbitofrontal-subcortical circuitry dysfunction was observed in OCD (8). On the other hand, evaluating patients with a history of acquired brain injury, especially in the orbito frontal cortex (OFC) and anterior cingulate cortex (ACC), showed OCD symptoms in the follow-up (9,10).…”

Section: Introductionmentioning

confidence: 99%

Episodic Memory in Obsessive-Compulsive Disorder: Comparison with Healthy Controls

et al. 2023

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Background: Obsessive-compulsive disorder is identified by intrusive thoughts and related compulsive behaviors. Memory complaints are controversial among obsessive-compulsive disorder patients. Objectives: The present study compared verbal, visual, episodic, and semantic memory between obsessive-compulsive disorder patients and healthy controls. Methods: This is a case-control study. The participants included 31 newly diagnosed obsessive-compulsive disorder outpatients and 30 healthy controls. The patients were selected using targeted sampling from Emam Reza Polyclinic, affiliated with blinded for peer review. They responded to a demographic checklist, structured clinical interview for DSM-IV (SCID-I), verbal and visual episodic memory from the Wechsler Memory Scale-Revised (WMS-R), and autobiographical memory interview (AMI). Results: The results indicated that patients with obsessive-compulsive disorder compared with the controls had lower scores in visual (P = 0.0001), verbal (P = 0.006), semantic (P = 0.3), and episodic memory (P = 0.001). Conclusions: All types of memory which were evaluated in the present study were impaired in obsessive-compulsive disorder. Memory impairment might explain the psychiatric symptoms of the disorder.

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The Relationship Between Trauma Exposure and Obsessive–Compulsive Disorder in Youth: A Systematic Review

Cited by 5 publications

References 90 publications

SAPAP3, SPRED2, and obsessive-compulsive disorder: the search for fundamental phenotypes

SAPAP3, SPRED2, and obsessive-compulsive disorder: the search for fundamental phenotypes

The Relationship between Childhood Trauma Experiences and Psychotic Vulnerability in Obsessive Compulsive Disorder: An Italian Cross-Sectional Study

Episodic Memory in Obsessive-Compulsive Disorder: Comparison with Healthy Controls

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