The relationship between tumor budding and survival in colorectal carcinomas

Abstract

SUMMARY OBJECTIVE Tumor budding is a parameter that is increasingly understood in colorectal carcinomas. We aimed to investigate the relationship between tumor budding, prognostic factors, and survival METHODS A total of 185 patients who had undergone colorectal surgery were observed. Tumor budding, the tumor budding score, and the relationship between these and prognostic factors, and survival investigated. RESULTS Tumor budding was found in 91 (49.2%) cases. The relationship between the tumor budding score and histological grade, lymphovascular invasion, perineural invasion, pathological lymph node stage, and mortality rates were significant. CONCLUSION In our study, the relationship between tumor budding and survival is very strong. Considering these findings and the literature, the prognostic significance of tumor budding becomes clear and should be stated in pathology reports.

Hubungan antara status tumor budding dengan berbagai parameter klinikopatologi pada adenokarsinoma kolorektal di RSUP Sanglah, Bali, Indonesia

“…Hal ini sejalan dengan penelitian yang dilakukan oleh Ozer SP et al, yang mendapatkan 107 laki-laki dan 78 perempuan dari total 185 kasus karsinoma kolorektal, dengan ratarata umur 60,5 tahun. 22 Pada penelitian ini juga mendapatkan umur termuda 16 tahun, namun tidak ditelusuri ada atau tidaknya faktor keluarga/keturunan yang berperan.…”

“…Hal ini juga sejalan dengan penelitian yang dilakukan oleh Ozer SP et al, yang mendapatkan lokasi terbanyak di kolon kiri (descendens 14,6%, sigmoid 25,4% dan rectum 22,2%) sedangkan kolon kanan hanya terdiri dari 59 (31,9%) kolon asendens dan 11 (5,9%) kolon transversum. 22 Grade adenokarsinoma kolorektal ditentukan berdasarkan bentukan glandular, dan dibagi menjadi 2 kelompok, yaitu low-grade (sebelumnya dikategorikan well differentiated dan moderately differentiated) dan high-grade (sebelumnya poorly differentiated). 17 Pada penelitian ini ditemukan dominasi lowgrade, yaitu sebanyak 74 sampel (90,0%).…”

“…Demikian pula dengan penelitian yang dilakukan oleh Ozer SP et al, yaitu didominasi oleh low-grade yang terdiri dari 30 (16,2%) low-grade /well differentiated dan 124 (67,0%) moderate/moderately differentiated, sedangkan sebanyak 31 kasus (16,8%) adalah high-grade/poorly differentiated. 22 Tumor budding diperkirakan sebagai refleksi epithelial-mesenchymal transition (EMT), dimana sel kanker kehilangan sifat epitelialnya seperti polaritas, dan adesi saat mengalami EMT. Dengan karakter mesenkimal, sel kanker memiliki kapasitas migrasi dan menjadi lebih resisten terhadap sinyal apoptosis.…”

Staging more important than grading? Evaluation of malignancy grading, depth of invasion, and resection margins in oral squamous cell carcinoma

“…Analyzing OSCC's patterns of growth gives valuable diagnostic and prognostic information, but a valid scoring and interpretation system has yet to be created. Recently, similar or derived concepts like tumor budding and cell nests have been evaluated for other entities [61,62] and OSCC [12,17,51,63] with promising results. Dichotomizing complex histological grading systems partly sacrifices diagnostic accuracy, but it can increase reproducibility and specificity of the diagnosis [31,64,65].…”

The relationship between tumor budding and survival in colorectal carcinomas

“…Carcinomas', by Peltek Ozer et al 1 for the Revista da Associação Médica Brasileira The authors investigated tumor budding (TB) by its new definition and reported that TB was an independent prognostic factor in colorectal carcinoma, which was also associated with perineural invasion, lymph node metastasis, lymphovascular invasion, and survival. The association with TB and perineural invasion has been reported in only a few studies; thus, Peltek Ozer et al's 1 study made a significant contribution to the literature.…”