E-learning has been and is an indispensable tool in the knowledge economy. It is attracting the special attention from many universities and educational institutions toward the goal of "learner-centric" because it is highly interactive, based on multimedia, enables learners to give exchange information more easily, and provides learning content that is appropriate to the capabilities and interests of each person. For more than forty years, e-learning has undergone a striking development that has paralleled technological breakthroughs. It, however, comes into the practice of education only upon integration into educational advances and based on the foundation of economic from three pillars: technology, education and economy, thereby highlighting the interactions among these factors and recommending orientations and synchronous solutions in this paper.