The Relationship Between Vitamin D and Postoperative Atrial Fibrillation: A Prospective Cohort Study

Ohlrogge, A; Brederecke, Jan; Ojeda, Francisco; Pecha, Simon; Börschel, Christin S.; Conradi, Lenard; Rimkus, Vanessa; Blankenberg, Stefan; Zeller, Tanja; Schnabel, Renate B.

doi:10.3389/fnut.2022.851005

Cited by 8 publications

(9 citation statements)

References 42 publications

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“…Conflicting results were seen by a prospective cohort study by Ohlrogge et al for POAF with VDD. 6 Many of the studies commented on VDD and POAF, though they have not conducted the studies with supplementation of vitamin D.…”

Section: Discussionmentioning

confidence: 99%

“…The postoperative ICU stay and complications are higher in pediatric cardiac surgery patients with VDD. 3 However, a few recent articles have not detected any difference in postoperative outcome of VDD patients related to atrial fibrillation and other parameters, 6 In the hospital setup, perioperative vitamin D therapy is the way forward to normalize the serum level. Hence, the outcome of the therapy needs to be systematically reviewed for clinical recommendation.…”

Section: Introductionmentioning

confidence: 99%

“…9,10,19 However, Sahu et al 8 did not find any difference. Conflicting results were seen by a prospective cohort study by Ohlrogge et al for POAF with VDD 6. Many of the studies commented on VDD and POAF, though they have not conducted the studies with supplementation of vitamin D.Inotropes requirement: Jelveh-Moghaddam et al 11 reported a significant reduction in inotrope requirement in patients after supplementation of vitamin D. The vasoactive inotropic score (VIS) was less compared with placebo treatment.…”

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confidence: 98%

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Effect of Vitamin D Supplementation on Postoperative Outcomes in Cardiac Surgery Patients: A Systematic Review

Das

Bej

2022

Journal of Cardiac Critical Care TSS

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Background Vitamin D deficiency is a very common occurrence in cardiac patients. It has been proved that cardiac surgery and cardiopulmonary bypass accelerate the deficiency further. The postoperative outcomes of patients deteriorate in the presence of vitamin D deficiency. Perioperative supplementation of vitamin D is the only solution to the problem. Hence, the present systematic review was conducted to derive the efficacy and safety of vitamin D supplementation on postoperative outcomes in cardiac surgery patients. Method Publications over duration of last 10 years was searched from different database and web sites. The data from full-text research articles were analyzed for the effect on different postoperative outcomes and side effects. Result Eight randomized control trials were retrieved on the effect of perioperative vitamin D supplementation in cardiac surgery patients and their postoperative outcomes. Six articles (75%) were found to be in favor of improvement in postoperative outcome. Two articles (25%) did not find any difference of outcome between the control and treatment group. All the studies observed the restoration of vitamin D to normal and no adverse effects from supplementation. Conclusion Perioperative vitamin D supplementation improves the postoperative outcomes after cardiac surgery. It is effective and safe to supplement vitamin D in cardiac surgery patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 98%

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Effect of Vitamin D Supplementation on Postoperative Outcomes in Cardiac Surgery Patients: A Systematic Review

Das

Bej

2022

Journal of Cardiac Critical Care TSS

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“…The vast majority of the papers reviewed below addressed the effect of VitD deficiency and/or supplementation on the occurrence of PoAF in the context of coronary artery bypass grafting (CABG) [ 91 , 92 , 93 , 94 ]. During the hospitalization period following this procedure, patients often develop AF with varying frequency.…”

Section: Relationship Of Vitd Deficiency and Supplementation To The R...mentioning

confidence: 99%

The Possible Influence of Vitamin D Levels on the Development of Atrial Fibrillation—An Update

et al. 2023

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Atrial fibrillation (AF) is a severe and most common supraventricular arrhythmia in humans, which, if left untreated or treated ineffectively, can lead to ischemic stroke or heart failure. It has been suggested that serum vitamin D (VitD) deficiency may be one of the critical factors influencing the onset of AF, especially in the period after cardiac surgery, such as coronary artery bypass grafting. Several papers have indicated that VitD supplementation reduces the risk of AF, significantly reducing the proportion of patients between the control and study groups in both the pre- and postoperative periods. Factors that increase the risk of AF from VitD deficiency are also further indicated, and these are age, gender, weight, season or comorbidities. In addition, the cardiodepressive mechanism of VitD is not fully understood; however, it is suggested that it acts through at least two pathways. The first indicates a direct effect of VitD on atrial muscle degradation, while the second is related to the modulation of cardiovascular depression factors. Despite many reports showing correlations between no VitD concentrations on the development of AF, this topic is still widely debated and the results from these papers are still subject to doubt. Therefore, this review aims at describing in detail the problem of correlation between VitD deficiency and the development of AF associated mainly with the postoperative period, i.e., after cardiac surgery, especially pathogenesis, and results of this correlation, taking into account recent studies, limitations and future perspectives. Due to the fact that this is still a topical problem, we believe that the collection of the latest reports and a detailed description of the problem is most appropriate in this case.

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“…Most studies have been observational, with some randomized controlled trials (RCTs) also conducted. Still, their results have been mixed in establishing a correlation between low vitamin D levels and post-CABG AF [5][6][7][8][9][10]. To examine the impact of vitamin D supplementation on reducing POAF in patients with vitamin D deficiency or insufficiency, we performed a meta-analysis by combining data from three randomized controlled trials.…”

Section: Introductionmentioning

confidence: 99%

The Role of Vitamin D Supplementation Before Coronary Artery Bypass Grafting in Preventing Postoperative Atrial Fibrillation in Patients With Vitamin D Deficiency or Insufficiency: A Systematic Review and Meta-Analysis

Ansari¹,

Dhaliwal²,

Ansari³

et al. 2023

Cureus

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This study aims to evaluate the role of preoperative vitamin D supplementation before coronary artery bypass grafting (CABG) surgery in preventing postoperative atrial fibrillation (POAF) in vitamin D deficient or insufficient patients. Three randomized controlled trials (RCTs) comprising 448 subjects were selected after a detailed search was conducted on PubMed, Cochrane CENTRAL, Scopus, and Embase in December 2022. Analysis was run using RevMan (version 5.4.1; Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014). The analysis collected risk ratio (RR) and 95% confidence interval (CI) data from the relevant studies, which were then pooled using a random effects model. A significance level of less than 0.05 (p<0.05) was considered significant. Our analysis showed that compared with the standard of care, preoperative vitamin D supplementation in vitamin D deficient and insufficient patients effectively reduced POAF after CABG surgery (RR=0.6, 95% CI=0.4-0.9, P=0.01). There was no significant difference in the duration of hospitalization between the vitamin D supplementation group compared with the control following CABG (mean difference -0.85, 95% CI -2.13 to 0.43, P = 0.19). This meta-analysis shows that preoperative vitamin D supplementation in vitamin D deficient and insufficient patients undergoing CABG can reduce the rate of POAF. As POAF is associated with many complications, providing vitamin D supplementation to individuals with a vitamin D deficiency undergoing CABG can improve long-term cardiovascular outcomes following surgery.

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The Relationship Between Vitamin D and Postoperative Atrial Fibrillation: A Prospective Cohort Study

Cited by 8 publications

References 42 publications

Effect of Vitamin D Supplementation on Postoperative Outcomes in Cardiac Surgery Patients: A Systematic Review

Effect of Vitamin D Supplementation on Postoperative Outcomes in Cardiac Surgery Patients: A Systematic Review

The Possible Influence of Vitamin D Levels on the Development of Atrial Fibrillation—An Update

The Role of Vitamin D Supplementation Before Coronary Artery Bypass Grafting in Preventing Postoperative Atrial Fibrillation in Patients With Vitamin D Deficiency or Insufficiency: A Systematic Review and Meta-Analysis

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