The Relationship Between Vitamin D Levels and the Quality of Life in Patients with Alopecia Areata and Vitiligo

Namdar, Nazlı Dizen; Arıkan, İnci

doi:10.4274/tod.galenos.2019.19327

Tod

2019

DOI: 10.4274/tod.galenos.2019.19327

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The Relationship Between Vitamin D Levels and the Quality of Life in Patients with Alopecia Areata and Vitiligo

Nazlı Dizen Namdar¹,

İnci Arıkan²

Abstract: Giriş Alopesi areata (AA), saçlı deri veya vücutta herhangi bir bölgedeki kılların, ani, skatrissiz bir şekilde dökülmesiyle seyreden, organ spesifik otoimmün kıl folikülü hastalığıdır (1). Toplumda AA riski yaşam boyu yaklaşık olarak %1,7 olarak bildirilmiş olup, yaş, etnik köken, cinsiyet farklılığı göstermemektedir (2,3). Vitiligo deri melanositlerinin yıkımı ile karakterize, depigmente maküllerle seyreden otoimmün bir hastalıktır (4). Tüm ırklarda görülebilen vitiligonun dünyadaki sıklığı %0,1-2 arasında d… Show more

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2024

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Cited by 1 publication

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Vitamin D deficiency in non-scarring and scarring alopecias: a systematic review and meta-analysis

Yongpisarn,

Tejapira,

Thadanipon

et al. 2024

Front. Nutr.

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BackgroundNumerous studies have linked vitamin D deficiency (VDD) to the pathogenesis of various alopecia disorders.ObjectiveThis study aimed to investigate whether patients with alopecia are more likely to have VDD or lower vitamin D levels than controls, and the prevalence of VDD among patients with certain alopecia disorders.MethodsElectronic searches were conducted using PubMed, Embase, Scopus, and Cochrane Library databases from the dates of their inception until September 2024. Studies that reported data allowing for the calculation of odds ratios, mean differences, or correlation coefficients related to vitamin D levels and alopecia were included, while studies without a confirmed diagnosis of alopecia or those involving patients taking vitamin D supplements were excluded.ResultsIt was found that 51.94% of patients with alopecia areata (AA), 50.38% of patients with female pattern hair loss (FPHL), 47.38% of patients with male androgenic alopecia (MAGA), 53.51% of patients with telogen effluvium (TE), and 38.85% of patients with primary scarring alopecia had VDD. Compared to controls, AA patients had a pooled odds ratio (OR) of VDD of 2.84 (95% confidence interval: 1.89–4.26, I2 = 84.29%, p < 0.01) and a pooled unstandardized mean difference (UMD) of vitamin D levels of −8.20 (−10.28 – −6.12, I2 = 74.25%, p < 0.01) ng/mL. For FPHL patients, a pooled OR of VDD of 5.24 (1.50–18.33, I2 = 81.65%, p < 0.01) and a pooled UMD of vitamin D levels of −15.67 (−24.55 – −6.79, I2 = 91.60%, p < 0.01) ng/mL were found. However, for MAGA, a pooled VDD OR of 4.42 (0.53–36.61, I2 = 88.40%, p < 0.01), and a pooled UMD of vitamin D levels of −2.19 ng/mL (−4.07 – −0.31 ng/mL, I2 = 7.64%, p = 0.37) were found. For TE patients, pooled UMD of vitamin D levels of −5.71 (−10.10 – −1.32) ng/mL were found.ConclusionPeople with alopecia frequently have VDD; however, only in patients with AA or FPHL was the association of VDD and decreased vitamin D levels statistically significant compared to control. The findings indicate screening for vitamin D could benefit patients with AA or FPHL, potentially addressing vitamin D deficiency. Further study on vitamin D supplementation as a treatment for alopecia is recommended.

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Vitamin D deficiency in non-scarring and scarring alopecias: a systematic review and meta-analysis

Yongpisarn,

Tejapira,

Thadanipon

et al. 2024

Front. Nutr.

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show abstract

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The Relationship Between Vitamin D Levels and the Quality of Life in Patients with Alopecia Areata and Vitiligo

Cited by 1 publication

References 6 publications

Vitamin D deficiency in non-scarring and scarring alopecias: a systematic review and meta-analysis

Vitamin D deficiency in non-scarring and scarring alopecias: a systematic review and meta-analysis

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