"The Relationship of Chronic Rhinosinusitis with Nasal Polyps and PDL-1"

Abstract

Background/Aim: Our aim is to explain the presence of pdl1 in nasal polyp by immunohistochemical method. Detecting the PD-1 changes in nasal polyp tissue may explain the development of chronic rhinosinusitis with nasal polyps and may help develop new methods in the treatment of nasal polyps.Methods: 20 patients who underwent endoscopic sinus surgery due to nasal polyps and 20 patients who underwent surgery for functional and/or aesthetic reasons and whose septum and turbinate mucosa were removed were included retrospectively. Thick sections were taken from paraffin blocks for applying immunohistochemical PDL-1 antibodies.Results: PDL-1 positivity in nasal polyp tissues was significantly higher than normal nasal mucosa epithelium (P=0.01). The recurrence rate was significantly increased in patients with PDL-1 staining compared to other patients. (P=0.006) Conclusion: PDL-1 was significantly increased in our patients with CRSwNP and presence of PDl-1 is a predictive factor for recurrence in nasal polyposis.