The relationship of sperm parameters to cycle fecundity in superovulated women undergoing intrauterine insemination

Horvath, Peter M.; Bohrer, Michael; Shelden, Robert M.; Kemmann, Ekkehard

doi:10.1016/s0015-0282(16)60857-9

Cited by 107 publications

(53 citation statements)

References 16 publications

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“…The overall clinical pregnancy rate (14%) observed with therapeutic IUI plus ovulation induction using gonadotropins was comparable with our previous results (1 1%) as well as with other published reports [ 12,18,19,291. The pregnancy rate in the present study did not appear to vary if the timing of hCG administration occurred when the follicles reached a definite size (16 mm) or was evaluated by the onset of an endogenous LH surge.…”

Section: Discussionsupporting

confidence: 91%

“…Other authors have reported CPRs ranging from 3% to 15% [ 12,18). The improvement in results of the present study may reflect the more selective use of suitable sperm for IUI (poor morphology but normal concentration and motility), as compared with our previous series in which most of the male factor patients presented with more serious concentration and motility problems.…”

Section: Discussionsupporting

confidence: 49%

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Therapeutic Intrauterine Insemination Improves with Gonadotropin Ovarian Stimulation

Ramey

Vaintraub

et al. 1993

Archives of Andrology

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. The patients were preferentially treated with ovulation induction with gonadotropins. With the addition ofgonadotropin stimulation, the total and term pregnancy rates per cycle were 14% and 1 1%, respectively, includingalletiologicfactors. These rates were improvedoverthe3%and 2.6%ratesreported inour previousstudy inwhichovarianstirnulationwasnotgenerallyused. Inniale factor patients, the term pregnancy rate was 9%, higher than the 4% term pregnancy rate reported in our previous study. In the present series, morphology was the only severely impaired parameter. The term pregnancy rate was 1 1 % for patients with ovulatory dysfunction, 10% for those with cervical factor, and 10.5% for those with unexplained infertility.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 49%

Therapeutic Intrauterine Insemination Improves with Gonadotropin Ovarian Stimulation

Ramey

Vaintraub

et al. 1993

Archives of Andrology

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“…This group of patients formed the 9.5% of our infertile population. In previous studies, the cutoff value above which IUI seems to be more successful, varies between 0.25-5x10 6 sperms/ mL [13][14][15]. Ombelet et al emphasized the importance of morphology especially in cases with inseminating sperm counts below 1x10 6 /mL and the authors implied low success rates in this group of patients [12].…”

Section: Discussionmentioning

confidence: 98%

Alterations in the morphology and motility of spermatozoa: relation with total sperm count

Karabulut¹,

Tekin²

2013

Pau Med J

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Purpose: The aim of this study was to investigate the differences in sperm morphology and motility in patients with different sperm counts, and to search the influence of sperm morphology over sperm motility. Materials and methods:We evaluated semen analysis of 1174 males admitted to infertility clinic using "Makler counting camber" for evaluation of number and motility, and strict criteria (Kruger-Tyberg) for the morphological assessment. According to total sperm count, patients were divided into three groups; group I (n=119) had <5x10 6 /mL, group II (n=125) had 5-15x10 6 /mL, and group III (n=930) had ≥15x10 6 /mL total sperm count. The groups were compared in terms of motility, morphology and the distribution of sperm abnormalities. Results: Sperm motility was significantly lower in groups I-II compared to group III (p<0.01). In the semen analysis, normal sperm morphology above 4% was detected in 7.1% of group II, 17.5% of group III, and none in group I (p<0.01). Significantly less tail defects were detected in group III compared to others (p<0.01). Progressive sperm motility significantly correlated with morphology (r=0.38, p<0.001). Among morphologic abnormalities, tail problems were highly correlated with nonmotile sperm count (r=0.30, p<0.001). Tail defects correlated positively with midpiece (r=0.24, p<0.001), and negatively with head defects (r=-0.71, p<0.001). Normal sperm morphology had a negative relation with tail and midpiece defects (r=-0.20, p <0.001 and r=-0.30, p<0.001 respectively). Conclusion: Sperm motility and morphology were deteriorated with the decreasing sperm count in subfertile population. The chance of finding normal morphology above the critical value of 4% diminishes in cases with sperm counts less than 5x10 6 /mL. Therefore, it is logical to canalize these patients directly to assisted reproductive technologies.Pam Med J 2013;6(1):1-4

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“…In general, there is an increase in the pregnancy rate with increasing numbers of motile sperm inseminated (20,21). Enabling the subfertile couple to achieve pregnancy via IUI can result in a significant savings for the couple.…”

Section: Discussionmentioning

confidence: 99%

Improved motile sperm recovery by a hyperosmotic percoll gradient

Carbone

Seifarth

Thomas

et al. 1997

J Assist Reprod Genet

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The relationship of sperm parameters to cycle fecundity in superovulated women undergoing intrauterine insemination

Cited by 107 publications

References 16 publications

Therapeutic Intrauterine Insemination Improves with Gonadotropin Ovarian Stimulation

Therapeutic Intrauterine Insemination Improves with Gonadotropin Ovarian Stimulation

Alterations in the morphology and motility of spermatozoa: relation with total sperm count

Improved motile sperm recovery by a hyperosmotic percoll gradient

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