The relationship of triphosphopyridine nucleotide content to abnormalities in the erythrocytes of premature infants

Gross, Ruth T.; Schroeder, E.

doi:10.1016/s0022-3476(63)80274-7

Cited by 11 publications

(3 citation statements)

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“…This observation is of interest in view of abnormalities characteristic of the erythrocytes of young infants. Limited availability of TPN in particular has been considered a possible explanation for the increased susceptibility to Heinz body formation and drug-induced hemolysis in newborn infants (43). It should be emphasized, therefore, that measurements in this study have been obtained in the absence of oxidative stress to the erythrocytes.…”

Section: Resultsmentioning

confidence: 97%

Pyridine nucleotides in erythrocyte metabolism.

Gross¹,

Schroeder²,

Gabrio³

1966

J. Clin. Invest.

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In recent years investigations of erythrocyte metabolism have been concerned with the interrelationships of enzymes, coenzymes, substrates, cofactors, and pH, inter alia (1-8). Although data have accumulated on these various aspects of the metabolism of normal and pathological erythrocytes, little direct information has been available heretofore on pyridine nucleotide coenzymes, despite their importance in both the glycolytic and the hexose monophosphate shunt pathways. The availability of these compounds in the blood of immature subjects is of particular interest because of certain abnormalities in the erythrocytes of fullterm newborn and prematurely born infants. These abnormalities, which include decreased survival of 51Cr-labeled erythrocytes in premature infants (9, 10) and increased susceptibility to Heinz body formation (11) and to methemoglobinemia (12-15) in both full-term and premature infants, as well as the occurrence of unexplained hemolytic anemias, suggest the possibility of transient biochemical defects in the erythrocytes of these young subjects. Although the activities of the pyridine nucleotide-dependent enzymes in both the glycolytic and shunt pathways are increased in the erythrocytes of young infants (16,17), the levels of the oxidized and reduced coenzymes themselves have not been reported.In the present study the concentrations of DPN,l

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Section: Resultsmentioning

confidence: 97%

Pyridine nucleotides in erythrocyte metabolism.

Gross¹,

Schroeder²,

Gabrio³

1966

J. Clin. Invest.

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“…Analogies in vitro are evident between damage produced in erythrocytes by certain substances known for their capacity to induce formation of hydrogen peroxide, and damage produced directly by hydrogen peroxide, whereas in vivo substances, having in common the capacity to induce H 20 2 formation, have a noticeably different action both in normal erythrocytes and erythrocytes with metabolic abnor malities [1,3,10].…”

Section: Discussionmentioning

confidence: 99%

Hydrogen Peroxide Generation in the Erythrocytes of Newborn Infants

Bracci¹,

Benedetti²,

Ciambellotti³

1970

Neonatology

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“…), deren Anwendungin der frühen Säuglingszeit das Krankheitsbild der toxischen hämolytischen Innenkörperanämie auslösen kann [4,14,16,42]. Die erhöhte Heinzkörperempfindlichkeit von Neugeborenenerythrozyten konnte in vitro erstmals von K ünzer et al [30] nachgewiesen und von anderen Autoren bestätigt werden [4,7,11,20,39,40,41,43]. Die Ursache dafür ist nicht befriedigend geklärt.…”

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