The relationships among ecto- and endoparasite levels, class I antigens of the bovine major histocompatibility system, immunoglobulin E levels and weight gain

Stear, M. J.; Hetzel, D. J. S.; Brown, SC; Gershwin, Laurel J.; Mackinnon, M. J.; Nicholas, F. W.

doi:10.1016/0304-4017(90)90077-o

Cited by 65 publications

(33 citation statements)

References 17 publications

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“…Their review did not differentiate between livestock reared in temperate and tropical environments or under extensive and intensive production systems. Among ectoparasites in cattle, they reported significant heritabilities for nematode species (Stear et al, 1990;Mackinnon et al, 1991, both based on a subset of data from northern Australia reported herein); tick infestations (Stear et al, 1990;Minjauw and de Castro, 2000); and buffalo fly numbers (Stear et al, 1990). Among endoparasites, they reported significant heritabilities for resistance to trypanosomes (Murray et al, 1991) and also indicated the heritability of immune response traits could be substantial in pigs and dairy cattle.…”

Section: Component Traits Of Female Reproductionmentioning

confidence: 70%

Importance of adaptation and genotype × environment interactions in tropical beef breeding systems

Burrow

2012

Animal

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This paper examines the relative importance of productive and adaptive traits in beef breeding systems based on Bos taurus and tropically adapted breeds across temperate and (sub)tropical environments. In the (sub)tropics, differences that exist between breeds in temperate environments are masked by the effects of environmental stressors. Hence in tropical environments, breeds are best categorised into breed types to compare their performance across environments. Because of the presence of environmental stressors, there are more sources of genetic variation in tropical breeding programmes. It is therefore necessary to examine the genetic basis of productive and adaptive traits for breeding programmes in those environments. This paper reviews the heritabilities and genetic relationships between economically important productive and adaptive traits relevant to (sub)tropical breeding programmes. It is concluded that it is possible to simultaneously genetically improve productive and adaptive traits in tropically adapted breeds of beef cattle grazed in tropical environments without serious detrimental consequences for either adaptation or production. However, breed-specific parameters are required for genetic evaluations. The paper also reviews the magnitude of genotype 3 environment (G 3 E) interactions impacting on production and adaptation of cattle, where 'genotype' is defined as breed (within a crossbreeding system), sire within breed (in a within-breed selection programme) or associations between economically important traits and single nucleotide polymorphisms (SNPs -within a marker-assisted selection programme). It is concluded that re-ranking of breeds across environments is best managed by the use of the breed type(s) best suited to the particular production environment. Re-ranking of sires across environments is apparent in poorly adapted breed types across extreme tropical and temperate environments or where breeding animals are selected in a temperate environment for use in the (sub)tropics. However, G 3 E interactions are unlikely to be of major importance in tropically adapted beef cattle grazed in either temperate or (sub)tropical environments, although sex 3 environment interactions may provide new opportunities for differentially selecting to simultaneously improve steer performance in benign environments and female performance in harsher environments. Early evidence suggests that re-ranking of SNPs occurs across temperate and tropical environments, although their magnitude is still to be confirmed in well-designed experiments. The major limitation to genetic improvement of beef cattle over the next decade is likely to be a deficiency of large numbers of accurately recorded phenotypes for most productive and adaptive traits and, in particular, for difficult-to-measure adaptive traits such as resistance to disease and environmental stressors.

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Section: Component Traits Of Female Reproductionmentioning

confidence: 70%

Importance of adaptation and genotype × environment interactions in tropical beef breeding systems

Burrow

2012

Animal

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“…The major histocompatibility complex (MHC) appears to be implicated in differential patterns of resistance to a number of parasitic helminths of sheep, cattle and mice (Else and Wakelin, 1989; Stear et al . 1990; Wassom and Kelly, 1990; Behnke and Wahid, 1991; Outteridge et al .…”

Section: Discussionmentioning

confidence: 99%

FVB/N mice are highly resistant to primary infection withNippostrongylus brasiliensis

et al. 2009

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SUMMARYNippostrongylus brasiliensislarvae are particularly susceptible to immunological attack during the pre-lung stage of primary and secondary infections in mice. Whilst most of the common laboratory strains of mice are permissive hosts for the parasite, in this study we report for the first time, the strong resistance of naïve FVB/N mice toN. brasiliensis. Damage to larvae is evident within the first 24 h of infection and this may be critical to later larval development and reproductive success. Inflammatory responses in the skin, and larval escape from this tissue were comparable in susceptible CBA/Ca and resistant FVB/N mice, with most larvae exiting within 4 h of a primary infection. Lung larval burdens were also similar between strains, but larvae recovered from FVB/N mice were smaller and less motile. In FVB/N mice, larval colonization of the gut was impaired and worms produced very few eggs. However FVB/N mice did not show enhanced resistance toHeligmosomoides bakeri(also known asHeligmosomoides polygyrus), a nematode largely restricted to the gut. Damage done in the pre-lung or lung stages of infection withN. brasiliensisis likely to contribute to ongoing developmental and functional abnormalities, which are profoundly evident in the gut phase of infection.

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“…Previous genetic studies found that the bovine leucocyte antigens (BoLA) were associated with tick burden [13,14] and these associations have more recently been confirmed using DNA polymorphisms [15-17], but the same allele has not always been associated with reduced tick numbers limiting the use of those markers in different populations. Whole genome scans using DNA microsatellites in linkage analyses have identified a small number of QTL associations [18,19] and a low density genome wide association study (GWAS) identified single nucleotide polymorphisms (SNP) associated with tick burden in several regions of the genome [20].…”

Section: Introductionmentioning

confidence: 99%

Haplotypes that include the integrin alpha 11 gene are associated with tick burden in cattle

et al. 2010

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BackgroundInfestations on cattle by the ectoparasite Boophilus (Rhipicephalus) microplus (cattle tick) impact negatively on animal production systems. Host resistance to tick infestation has a low to moderate heritability in the range 0.13 - 0.64 in Australia. Previous studies identified a QTL on bovine chromosome 10 (BTA10) linked to tick burden in cattle.ResultsTo confirm these associations, we collected genotypes of 17 SNP from BTA10, including three obtained by sequencing part of the ITGA11 (Integrin alpha 11) gene. Initially, we genotyped 1,055 dairy cattle for the 17 SNP, and then genotyped 557 Brahman and 216 Tropical Composite beef cattle for 11 of the 17 SNP. In total, 7 of the SNP were significantly (P < 0.05) associated with tick burden tested in any of the samples. One SNP, ss161109814, was significantly (P < 0.05) associated with tick burden in both the taurine and the Brahman sample, but the favourable allele was different. Haplotypes for three and for 10 SNP were more significantly (P < 0.001) associated with tick burden than SNP analysed individually. Some of the common haplotypes with the largest sample sizes explained between 1.3% and 1.5% of the residual variance in tick burden.ConclusionsThese analyses confirm the location of a QTL affecting tick burden on BTA10 and position it close to the ITGA11 gene. The presence of a significant association in such widely divergent animals suggests that further SNP discovery in this region to detect causal mutations would be warranted.

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The relationships among ecto- and endoparasite levels, class I antigens of the bovine major histocompatibility system, immunoglobulin E levels and weight gain

Cited by 65 publications

References 17 publications

Importance of adaptation and genotype × environment interactions in tropical beef breeding systems

Importance of adaptation and genotype × environment interactions in tropical beef breeding systems

FVB/N mice are highly resistant to primary infection withNippostrongylus brasiliensis

Haplotypes that include the integrin alpha 11 gene are associated with tick burden in cattle

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