The Relationships Between the High Production of Prostaglandins by Tumors and their Action on Lymphocytes as Suppressive Agents

Tomasi, Vittorio; Mastacchi, R.; Bartolini, G; Fadda, S.; Barnabei, O.; Gatto, R.; Barboni, F; Trevisani, Agostino; Capuzzo, Antonio; Ferretti, Maria Enrica; Pareschi, Maria Cristina; Martelli, Giuseppe; Danieli, Roberta; Rossini, Silvano

doi:10.1007/978-1-4684-4856-6_24

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The Possible Role Of Prostanoidv In Human Monocytes1

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1990

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“…While the role ofPGE 2 production is in the control of lymphocyte activity and/or proliferation [45][46][47][48], the role of thromboxane A2 is much more difficult to ascertain. We have hypothesized a function of this prostanoid as a mediator of monocyte cytotoxicity [18].…”

Section: The Possible Role Of Prostanoidv In Human Monocytesmentioning

confidence: 99%

Prostanoids as second messengers of polypeptide growth factors

et al. 1990

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Prostaglandin H synthase (PGHs), also known as cyclooxygenase, is an unstable enzyme whose mRNA has an half life of 10 minutes. Some polypeptide factors have been reported to induce the enzyme in target cells. We have purified and characterized a component of animal sera which behaves as a potent inducer of human monocyte PGHs. This factor, called serum monocytotropic factor, has been identified in human platelets and it appears to be structurally and biochemically different from identified platelet factors, such as platelet derived growth factor (PDGF) and transforming growth factor beta (TGF-beta), while showing strong similarities to colony stimulating factor 1 (CSF-1), so far undetected in platelets. Moreover, we have shown, by immunoblot analysis, that CSF-1 behaves as a potent and specific inducer of monocyte PGHs. The hypothesis that prostanoids may be considered as second messengers of platelet CSF-1 like factor, as well as of other growth factors and that PGHs induction plays a pivotal role in this process, will be illustrated.

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Section: The Possible Role Of Prostanoidv In Human Monocytesmentioning

confidence: 99%