The relationships between urinary phthalate metabolites, reproductive hormones and semen parameters in men attending in vitro fertilization clinic

Al‐Saleh, Iman; Coşkun, Serdar; Al-Doush, Inaam; Al-Rajudi, Tahreer; Abduljabbar, Mai; Al-Rouqi, Reem; Palawan, Hemraz; Al-Hassan, Saad

doi:10.1016/j.scitotenv.2018.12.261

Cited by 40 publications

(22 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mendiola et al [ 199 ] observed decreased estradiol levels in men with increased levels of MEHP. In the studies of Chang et al [ 107 ] and Al-Saleh et al [ 197 ] we observed positive associations between the metabolites of DEHP in men with prostatic hyperplasia and DEP in healthy men, respectively, and levels of estradiol. These conflicting results are likely attributed to the exposure to different phthalate diesters and reproductive disorders’ occurrence.…”

Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 49%

“…Similarly, in men with benign prostatic hyperplasia, estradiol levels, testosterone and steroidogenic enzymes aromatase, and 5α-reductase were increased [ 107 ]. Other studies observed associations between postnatal exposure to phthalates in healthy and infertile men and decreased testosterone [ 80 , 194 , 195 , 196 , 197 , 198 ]. Epidemiological studies yielded some conflicting results in the association between phthalate exposure and estradiol levels in men.…”

Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 99%

See 1 more Smart Citation

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Hlisníková

Petrovičová

Kolena

et al. 2020

IJERPH

163

View full text Add to dashboard Cite

The production of plastic products, which requires phthalate plasticizers, has resulted in the problems for human health, especially that of reproductive health. Phthalate exposure can induce reproductive disorders at various regulatory levels. The aim of this review was to compile the evidence concerning the association between phthalates and reproductive diseases, phthalates-induced reproductive disorders, and their possible endocrine and intracellular mechanisms. Phthalates may induce alterations in puberty, the development of testicular dysgenesis syndrome, cancer, and fertility disorders in both males and females. At the hormonal level, phthalates can modify the release of hypothalamic, pituitary, and peripheral hormones. At the intracellular level, phthalates can interfere with nuclear receptors, membrane receptors, intracellular signaling pathways, and modulate gene expression associated with reproduction. To understand and to treat the adverse effects of phthalates on human health, it is essential to expand the current knowledge concerning their mechanism of action in the organism.

show abstract

Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 49%

Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 99%

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Hlisníková

Petrovičová

Kolena

et al. 2020

IJERPH

163

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 98%

“…Indeed, MEHP, MnBP and mono-isobutylphthalate (MiBP) levels were found to be inversely related with total and free testosterone, free androgen index and luteinizing hormone, while a positive association was reported with DNA fragmentation index. Overall phthalate exposure was associated also with altered reproductive hormones concentrations, linked to some extent to a lower semen quality [24].To understand how phthalates could affect male reproduction, numerous in vitro and in vivo studies were carried out. The diethylhexylphthalate (DEHP) exposure induced, in rats, testicular toxicity through oxidative stress injury, DEHP levels were linked to the decrement of testosterone levels and upregulated the expression of the nuclear factor-erythroid 2 related factor (Nrf2) [25].…”

mentioning

confidence: 99%

Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Caporossi

Alteri

Campo

et al. 2020

IJERPH

View full text Add to dashboard Cite

Among the possible risk factors for male reproduction, exposure to phthalates and alkylphenols is widely documented. This study evaluated the possible association between chemical exposure and the quality of the seminal fluid of 105 subjects in a fertility clinic. The urinary levels of seven phthalate metabolites (monoethylphthalate, MEP; monobenzylphthalate, MBzP; mono n-butylphthalate, MnBP; mono-(2-ethylhexyl) phthalate, MEHP; mono(2-ethyl-5-hydroxyhexyl) phthalate, MEHHP; mono-n-octylphthalate, MnOP; mono-isononylphthalate, MiNP) and bisphenol A (BPA), were analysed by high performance liquid chromatography/tandem mass spectrometry HPLC/MS/MS. The regression analysis showed that the semen volume was positively associated with MnBP, MnOP and BPA levels while was negatively associated with MiNP levels. The sperm concentration had a significant inverse relationship with MEP levels. A negative association was found between the use of plastic containers for food storage (p = 0.037) and semen volume (3.06 vs. 2.30 mL as average values, never vs daily). A significant positive correlation emerged (p < 0.005) between the consumption of canned food and the levels of BPA (2.81 vs. 0.14 µg/g creat as average values, daily vs. never) and between the use of perfumes and levels of MEP (389.86 vs. 48.68 µg/g creat, as average values, daily vs. never). No further statistically significant associations were found, even considering the working activity. Some evidence emerged about the possible link between exposure and seminal fluid quality: further case/control or prospective studies will allow us to confirm this causality hypothesis.

show abstract

“…A multicenter American study investigated the urinary concentrations of various phthalate esters in 420 fertile men (aged 32 ± 6 years), finding an inverse correlation only between MBzP and sperm motility [84]. A single-center study conducted in 2018 on 599 men from couples about to undergo IVF/ICSI attending an assisted reproduction center found an inverse correlation between some phthalate esters and sperm concentration, but not with motility or abnormal forms [87].…”

Section: Clinical Data: the Real-life Impact Of Bpa And Phthalates Onmentioning

confidence: 99%

Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates

Pallotti

Pelloni

Gianfrilli

et al. 2020

JCM

View full text Add to dashboard Cite

Great attention has been paid in recent years to the harmful effects of various chemicals that interfere with our natural hormone balance, collectively known as endocrine-disrupting chemicals (EDCs) or endocrine disruptors. The effects on the reproductive system of bisphenol A (BPA) and phthalates have received particular attention: while they have a short half-life, they are so widespread that human exposure can be considered as continuous. Evidence is often limited to the animal model, disregarding the likelihood of human exposure to a mixture of contaminants. Data from animal models show that maternal exposure probably has harmful effects on the male fetus, with an increased risk of urogenital developmental abnormalities. After birth, exposure is associated with changes in the hypothalamic-pituitary-testicular axis, hindering the development and function of the male genital pathways through the mediation of inflammatory mechanisms and oxidative stress. The epidemiological and clinical evidence, while generally confirming the association between reproductive abnormalities and some phthalate esters and BPA, is more contradictory, with wildly different findings. The aim of this review is therefore to provide an update of the potential mechanisms of the damage caused by BPA and phthalates to reproductive function and a review of the clinical evidence currently available in the literature.

show abstract

The relationships between urinary phthalate metabolites, reproductive hormones and semen parameters in men attending in vitro fertilization clinic

Cited by 40 publications

References 116 publications

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates

Contact Info

Product

Resources

About