The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study

Visser, Annemieke; Mutsert, Renée de; Cessie, Saskia le; Heijer, Martin den; Rosendaal, Frits R.; Kloppenburg, Margreet

doi:10.1136/annrheumdis-2013-205012

Cited by 172 publications

(82 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Here, the model of HIV-1 infection further supports the ‘metabolic’ OA phenotype because the prevalence of HOA was greater in patients with MetS than without MetS 17–19. Of note, obesity was not associated with HOA diagnosis in the METAFIB-OA study: such a result agrees with those from the population-based Netherlands Epidemiology of Obesity cohort, finding HOA linked more to metabolic systemic factors than weight itself 22. Radiographic severity was more severe in patients with MetS, so MetS is a risk factor and also an aggravating factor of radiographic HOA during HIV infection.…”

Section: Discussionsupporting

confidence: 78%

Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study

et al. 2016

View full text Add to dashboard Cite

Objective To determine radiographic hand osteoarthritis (HOA) prevalence in patients with HIV-1 infection in comparison with the general population and to address whether metabolic syndrome (MetS) may increase the risk of HOA during HIV-1 infection. Patients Patients with HIV-1 infection and MetS (International Diabetes Federation, IDF criteria) aged 45–65 years were matched by age and gender to HIV-1-infected subjects without MetS and underwent hand radiographs. Framingham OA cohort was used as general population cohort. Methods Radiographic HOA was defined as Kellgren–Lawrence (KL) score ≥2 on more than one joint. Radiographic severity was assessed by global KL score and number of OA joints. HOA prevalence was compared with that found in the Framingham study, stratified by age and sex. Logistic and linear regression models were used to determine the risk factors of HOA in patients with HIV-1 infection. Results 301 patients (88% male, mean age 53.4 ±5.0 years) were included, 152 with MetS and 149 without it. Overall, HOA prevalence was 55.5% and was higher for those with MetS than those without it (64.5% vs 46.3%, p=0.002). When considering men within each age group, HOA frequency was greater in patients with HIV-1 infection than the general population (all ages: 55.8% vs 38.7%; p<0.0001), due to the subgroup with MetS (64.9%; p<0.0001), as well as the subgroup without MetS, although not significant (46.6%; p=0.09). Risk of HOA was increased with MetS (OR 2.23, 95% 95% CI 1.26% to 3.96%) and age (OR 1.18, 95% CI 1.12 to 1.25). HOA severity was greater for patients with MetS than those without. HOA was not associated with previous or current exposure to protease inhibitors or HIV infection-related markers. Conclusions HOA frequency is greater in patients with HIV-1 infection, especially those with MetS, than the general population.

show abstract

Section: Discussionsupporting

confidence: 78%

Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Four studies described the adjusted OR [7, 11–13]. After pooling the adjusted ORs, the results remained significant (pooled adjusted OR = 1.05, 95% CI = 1.03–1.07, and p < 0.00001) (Figure 5).…”

Section: Resultsmentioning

confidence: 95%

“…After a systematic review, 8 studies with a total of 3,202 cases and 20,968 controls were finally included. Among these studies, there were two prospective studies [7, 13], three cross-sectional studies [9, 10, 12], and three case-control studies [8, 11]. One study was excluded for lack of data [18].…”

Section: Resultsmentioning

confidence: 99%

Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta‐Analysis

Wang

Cheng

Shao

et al. 2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Studies revealed that metabolic factors might contribute substantially to osteoarthritis (OA) pathogenesis. There has been an increasing interest to understand the relationship between knee OA and the metabolic syndrome (MetS). The purpose of this study was to explore the association between metabolic syndrome and knee osteoarthritis using meta-analysis. Methods. Databases, including PUBMED, EMBASE, and the Cochrane Library, were searched to get relevant studies. Data were extracted separately by two authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Results. The meta-analysis was finished with 8 studies with a total of 3202 cases and 20968 controls finally retrieved from the database search. The crude pooled OR is 2.24 (95% CI = 1.38–3.64). Although there was significant heterogeneity among these studies, which was largely accounted for by a single study, the increase in risk was still significant after exclusion of that study. The pooled adjusted OR remained significant with pooled adjusted OR 1.05 (95% CI = 1.03–1.07, p < 0.00001). No publication bias was found in the present meta-analysis. Conclusions. The synthesis of available evidence supports that metabolic syndrome increases the risk for knee osteoarthritis, even after adjustment for many risk factors.

show abstract

“…Moreover, overweight was found to be associated with hand OA as well, indicating a possible underlying systemic factor in disease pathogenesis 7 . The involvement of both metabolic and systemic aspects was demonstrated in cohort studies, where knee OA development did not depend on weight or BMI but was strongly related to concurrent dysregulation of glucose and lipid metabolism 8 .…”

Section: Introductionmentioning

confidence: 99%

Variable cartilage degradation in mice with diet-induced metabolic dysfunction: food for thought

Kozijn

Gierman

Ham

et al. 2018

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

Mouse model s u m m a r yObjective: Human cohort studies have demonstrated a role for systemic metabolic dysfunction in osteoarthritis (OA) pathogenesis in obese patients. To explore the mechanisms underlying this metabolic phenotype of OA, we examined cartilage degradation in the knees of mice from different genetic backgrounds in which a metabolic phenotype was established by various dietary approaches. Design: Wild-type C57BL/6J mice and genetically modified mice (hCRP, LDLr À/À . Leiden and ApoE*3-Leiden.CETP mice) based on C57BL/6J background were used to investigate the contribution of inflammation and altered lipoprotein handling on diet-induced cartilage degradation. High-caloric diets of different macronutrient composition (i.e., high-carbohydrate or high-fat) were given in regimens of varying duration to induce a metabolic phenotype with aggravated cartilage degradation relative to controls. Results: Metabolic phenotypes were confirmed in all studies as mice developed obesity, hypercholesteremia, glucose intolerance and/or insulin resistance. Aggravated cartilage degradation was only observed in two out of the twelve experimental setups, specifically in long-term studies in male hCRP and female ApoE*3Leiden.CETP mice. C57BL/6J and LDLr À/À . Leiden mice did not develop HFD-induced OA under the conditions studied. Osteophyte formation and synovitis scores showed variable results between studies, but also between strains and gender. Conclusions: Long-term feeding of high-caloric diets consistently induced a metabolic phenotype in various C57BL/6J (-based) mouse strains. In contrast, the induction of articular cartilage degradation proved variable, which suggests that an additional trigger might be necessary to accelerate diet-induced OA progression. Gender and genetic modifications that result in a humanized pro-inflammatory state (human CRP) or lipoprotein metabolism (human-E3L.CETP) were identified as important contributing factors. © 2017 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. IntroductionOsteoarthritis (OA) is a progressive joint disease that is characterised by focal loss of articular cartilage, which impedes smooth joint movement and causes stiffness and pain. The most important risk factors for OA are age, gender and obesity. The latter being of specific interest in developed countries, where prolonged life expectancy and a progressive sedentary lifestyle in combination with a high caloric diet is predicted to exponentially increase the number of obese individuals and hence the prevalence of OA The association between knee OA and obesity has been comprehensively studied in humans. Weight loss was found to significantly reduce pain and increase mobility in knee OA patients 3 and reduced the risk of onset of the disease 4 . In obese adults, weight loss combined with exercise appears to be the most promising treatment and is therefore recommended by several international guidelines on the management of metabolic OA 5,6 .Moreover, overweight was found to ...

show abstract

The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study

Abstract: In knee OA, whether or not in co-occurrence with hand OA, surrogates for mechanical stress are suggested to be the most important risk factors, whereas in hand OA alone, surrogates for systemic processes are the most important risk factors.

Cited by 172 publications

References 49 publications

Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study

Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study

Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta‐Analysis

Variable cartilage degradation in mice with diet-induced metabolic dysfunction: food for thought

Contact Info

Product

Resources

About