The release of Gentamycin into the wound secretions from polymethylmethacrylate beads

Härle, A.; Ritzerfeld, W

doi:10.1007/bf00379172

Cited by 20 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The choice of gentamicin is based upon its broad spectrum activity against Gram‐positive and Gram‐negative bacteria, the low incidence of microorganisms with intrinsic resistance and the low rate of allergy (Wahlig and others 1978). The concentration of gentamicin in wound secretions is many times higher than the mic values of the majority of pathogens and even exceeds the mic of pathogens which are normally resistant in standard disc tests (Harle and Ritzerfeld 1979). The concentration in wound secretions exceeds the mic values while the serum and urine concentrations remain low (Wahlig and others 1978).…”

Section: Discussionmentioning

confidence: 94%

Treatment of intrasynovial infection with gentamicin‐impregnated polymethylmethacrylate beads

et al. 1996

View full text Add to dashboard Cite

Gentamicin-impregnated polymethylmethacrylate beads were used in the treatment of infective synovitis in 12 horses and 10 cattle. They had either proved refractory to standard treatments (lavage, debridement, joint drainage and systemic antibiotics) or had evidence of osteomyelitis adjacent to a synovial cavity. All the animals were severely lame. All the cattle and six of the horses had radiological evidence of osteomyelitis in communication with a synovial cavity. The beads were placed intrasynovially under general anaesthesia and left in place for 14 days. One horse and one calf were euthanased owing to continued infective arthritis. The infection was eliminated from the other 20 cases and six of the horses returned to full athletic use. Eight of nine calves with E-type infective arthritis and osteomyelitis returned to their intended food production or breeding programmes.

show abstract

Section: Discussionmentioning

confidence: 94%

Treatment of intrasynovial infection with gentamicin‐impregnated polymethylmethacrylate beads

et al. 1996

View full text Add to dashboard Cite

show abstract

“…Antibiotic-loaded bone cavity fillers which are consisted of degradable or non-degradable materials can be used for local antibiotic delivery devices. This not only fills up the bone cavity after surgical debridement, but also can reduce antibiotic concentration in serum and offer high concentration of antibiotic at the local site of infections [4–8]. Antibiotic-loaded PMMA has been the gold standard vehicle for local antibiotic delivery in the treatment of chronic osteomyelitis, because the antibiotic delivery system can offer the advantage of local release of high antibiotic level at the site of infection, and simultaneously enable the dead space originating from surgical debridement.…”

Section: Introductionmentioning

confidence: 99%

Combination therapy with vancomycin-loaded calcium sulfate and vancomycin-loaded PMMA in the treatment of chronic osteomyelitis

Luo

Jiang

Yang

et al. 2016

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background: Chronic post-traumatic and postoperative osteomyelitis is a refractory disease which results in significant morbidity and mortality. The effect of combination therapy with vancomycin-loaded calcium sulfate and vancomycin-loaded polymethyl methacrylate (PMMA) was unknown. Methods: Fifty-one patients suffering from chronic post-traumatic or postoperative osteomyelitis of the lower extremities were included in the retrospective investigation. The patients were assigned to the study group of the combination therapy with antibiotic-loaded calcium sulfate and antibiotic-loaded PMMA or the control group of the antibiotic-loaded PMMA. Hematological parameters, eradication of infection, rate of infection recurrence and reoperation rate were evaluated during the follow-up. Results: The cases were followed up for an average of 24 months (range, 15-48 months) after the first-stage surgical operation. In the study group, all the patients revealed complete calcium sulfate resorption at an average of 6 weeks (range, 30-60 days). In the study group, infection was primarily eradicated in 92.31% (24 of 26) of patients and re-operation rate of 7.69% (2 of 26) after the first-stage surgery. Two patients underwent further surgical operation in the study group. One case achieved infection eradication in the recurrent two cases, with a secondary infection eradication rate of 96.15% (25 of 26). There was no persistent infection in the study group. In the control group, infection was eradicated in 64.00% (16 of 25) of patients and re-operation rate was 36.00% (9 of 25) after the first-stage surgery. Nine patients in the control group underwent further surgical operation. Two case achieved infection eradication in these cases who suffered from persistent or recurrent infection, with a secondary infection eradication rate of 72.00% (18 of 25). There was more re-operation rate in the control group (PMMA group, 9 vs combination therapy group, 2; P = 0.034).

show abstract

“…Therefore obtaining an effective local antibiotic concentration is hardly gained through oral or parental administration. Based on this knowledge, the local application of antibiotics, besides surgical debridement, represents a viable alternative treatment to handle osteomyelitis by reaching higher local antibiotic concentrations and minimizing systemic side effects [1]. …”

Section: Introductionmentioning

confidence: 99%

In Vitro Elution Characteristics of Gentamicin and Vancomycin from Synthetic Bone Graft Substitutes

Maier¹,

Roth²,

Andereya³

et al. 2013

TOORTHJ

View full text Add to dashboard Cite

Objects:Beta tricalciumphosphate pellets loaded with individualized antibiotics may represent novel options in the treatment of osteomyelitis and infectious bone disease. Here, the in vitro antibiotic elution of vancomycin and gentamicin from the synthetic bone graft substitutes Cerasorb® and Cerasorb M® was tested. Methods:Antibiotic elution and concentration of gentamcin and vancomycin were measured using photometrically-based measurement and homogeneous particle-enhanced turbidimetric inhibition immunoassays (PETINIA). Results:Initially both materials showed a high release of the loaded antibiotics, with Cerasorb M® showing lower release levels for gentamicin and vancomycin than Cerasorb®. Gentamicin concentrations of Cerasorb M granules and Cerasorb were below the minimum detectiontreshold until day four and six of the experiment respectively. The vancomycin release-level followed a similar pattern, although the vancomycin concentration eluted by Cerasorb M® granules stayed above the detection threshold during the experimental time.Conclusions: Cerasorb® and Cersorb M® may represent a new treatment option in osteomyelitis and infectious bone disease.

show abstract

The release of Gentamycin into the wound secretions from polymethylmethacrylate beads

Cited by 20 publications

References 7 publications

Treatment of intrasynovial infection with gentamicin‐impregnated polymethylmethacrylate beads

Treatment of intrasynovial infection with gentamicin‐impregnated polymethylmethacrylate beads

Combination therapy with vancomycin-loaded calcium sulfate and vancomycin-loaded PMMA in the treatment of chronic osteomyelitis

In Vitro Elution Characteristics of Gentamicin and Vancomycin from Synthetic Bone Graft Substitutes

Contact Info

Product

Resources

About