The reliability of specific primary progressive MS criteria in an ethnically diverse population

Vasconcelos, Cláudia Cristina Ferreira; Santos, Claudia M. Miranda; Alvarenga, Marcos Papais; Camargo, Solange M.G.; Alvarenga, Regina Maria Papais

doi:10.1016/j.jns.2008.03.001

Cited by 7 publications

(7 citation statements)

References 34 publications

(77 reference statements)

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“…Additionally, the detection of lesions in the posterior fossa and the spinal canal is more difficult compared to conventional spin echo sequences. Sagittal FLAIR shows MS lesions in the corpus callosum excellently (figures 8,9).…”

Section: Sequencesmentioning

confidence: 92%

MRI in Multiple Sclerosis

et al. 2009

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The diagnosis of Multiple Sclerosis (MS) is based on clinical findings that are characterized by sudden neurological deficits in different parts of the CNS. Dissemination of lesions in space and time is the basic criterion. MRI can demonstrate most precisely any changes in the water content of brain tissue thus making it a very sensitive diagnostic tool to detect inflammatory processes like MS plaques. The following will briefly summarize the diagnostic features and procedures and will assess the appearance of typical MS lesions, their localization and configuration, which are essential for diagnosis and follow up examinations. It will propose the preferred sequences and technical parameters for standardized baseline examinations and follow-ups.

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Section: Sequencesmentioning

confidence: 92%

MRI in Multiple Sclerosis

et al. 2009

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“…Ferreira Vasconcelos et al. 13 reported in 2008 the applicability of three sets of diagnostic criteria established to define primary progressive MS (PPMS) (Thompson 14 , McDonald 2001 1 and McDonald 2005 15 ), in a cohort of 52 native Brazilian patients, 33% of whom were non-Caucasian, and African background was identified for up of three generations, followed-up from 1995 to 2006 ( Table 1 ).…”

Section: Mcdonald Criteria and Their Applicability In Latammentioning

confidence: 99%

Application of the McDonald criteria in Latin America

Patrucco

2017

Multiple Sclerosis Journal - Experimental, Translational and Cl

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The diagnosis of multiple sclerosis (MS) is based on neurological symptoms and signs, alongside evidence of dissemination of central nervous system (CNS) lesions in space and time. In the absence of a sensitive and specific diagnostic test, diagnostic criteria are needed for diagnosing MS. The caveat to the application of the McDonald criteria is that alternative diagnoses must be excluded. The prevalence, clinical phenotype and the differential diagnosis of MS may have variations in different populations, especially in Latin America (LATAM). Considering that MS diagnostic criteria were developed with data gathered largely from adult Caucasian European and North American populations, their applicability and accuracy in ethnical/genetic diverse populations may be affected. There are scarce data in our region about the reliability of MS criteria.

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“…However, the diagnostic criteria have been validated in only a few studies in LATAM. 7 , 8 In addition, economic limitations remain a challenge for the availability of MRI and paraclinical testing, especially in non-urban areas of the region. The availability of DMTs is also quite variable, with some countries having access to almost all MS DMTs approved in North America/Europe, while in others there is only one or even no therapeutic options.…”

mentioning

confidence: 99%