The remission concept in type 1 diabetes and its significance in immune intervention

Yilmaz, MT

doi:10.1002/dmr.5610090415

Cited by 5 publications

(3 citation statements)

References 72 publications

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“…In firstdegree relatives of IDDM patients, with regard to glucose homeostasis, data vary from normal to subnormal or, even more surprisingly, to excessive insulin and C-peptide secretion in response to glucose and/or arginine (1)(2)(3)(4)(5)(6)(7)(8). In line with the possible existence of hyperactive ␤-cells at the prediabetic stage in humans, the following have been observed: 1) increased levels of insulin and proinsulin under basal fasting conditions in nondiabetic identical twins of IDDM patients (5,6); and 2) increased levels of proinsulin under basal conditions and after glucose stimulation in first-degree relatives or newly diagnosed patients (3, 9 -14).…”

Section: Nsulin-dependent Diabetes Mellitus (Iddm) or Typementioning

confidence: 99%

“…1 diabetes, has a long prodromic phase in both humans (in whom the detection of autoantibodies precedes diabetes onset by years) and spontaneous models of the disease, such as the nonobese diabetic (NOD) mouse (in which insulitis precedes hyperglycemia by weeks or months) (1,2). In firstdegree relatives of IDDM patients, with regard to glucose homeostasis, data vary from normal to subnormal or, even more surprisingly, to excessive insulin and C-peptide secretion in response to glucose and/or arginine (1)(2)(3)(4)(5)(6)(7)(8).…”

Section: Nsulin-dependent Diabetes Mellitus (Iddm) or Typementioning

confidence: 99%

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Glucose Homeostasis in the Nonobese Diabetic Mouse at the Prediabetic Stage¹

et al. 1998

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Because few data were available on glucose homeostasis at the early prediabetic stage in the nonobese diabetic (NOD) mouse, we investigated glycemia, insulinemia, and pancreatic insulin content under basal conditions in both sexes of 4-, 6-, and 8-week-old fed NOD mice, compared with sex-and age-matched fed C57BL/6 mice. We also investigated glucose tolerance in both sexes of fasting 8-week-old NOD and C57BL/6 mice. The main results obtained under basal fed conditions, when comparing both strains, were lower glycemia and higher insulinemia in NOD females at all ages investigated and in NOD males (particularly at 6 weeks of age). Glucose tolerance tests showed that: 1) the blood glucose response to 1 g/kg ip glucose was less sustained in both sexes of 8-week-old NOD mice than in their control counterparts; 2) the blood insulin response to glucose (1 g/kg ip) appeared earlier in both sexes of NOD mice than in sex-matched C57BL/6 mice; 3) an unusual sexual dimorphism existed in NOD mice, compared with controls, with females secreting, in response to glucose, twice as much insulin as males; 4) dose-response studies (1-6 g/kg glucose) confirmed the lower increase in blood glucose levels in both sexes of NOD mice and their unusual sexual dimorphism in insulin secretion; and 5) glucose tolerance tests in 4-to 8-week-old NOD mice showed that although the sexual dimorphism in insulin secretion was not observed in 4-week-old mice, it was particularly striking at 6 weeks of age. Taken together, these results suggest that ␤-cell hyperactivity exists in the NOD mouse at the early prediabetic stage, especially in NOD females. (Endocrinology 139: [1115][1116][1117][1118][1119][1120][1121][1122][1123][1124] 1998) I NSULIN-DEPENDENT diabetes mellitus (IDDM), or type 1 diabetes, has a long prodromic phase in both humans (in whom the detection of autoantibodies precedes diabetes onset by years) and spontaneous models of the disease, such as the nonobese diabetic (NOD) mouse (in which insulitis precedes hyperglycemia by weeks or months) (1, 2). In firstdegree relatives of IDDM patients, with regard to glucose homeostasis, data vary from normal to subnormal or, even more surprisingly, to excessive insulin and C-peptide secretion in response to glucose and/or arginine (1-8). In line with the possible existence of hyperactive ␤-cells at the prediabetic stage in humans, the following have been observed: 1) increased levels of insulin and proinsulin under basal fasting conditions in nondiabetic identical twins of IDDM patients (5, 6); and 2) increased levels of proinsulin under basal conditions and after glucose stimulation in first-degree relatives or newly diagnosed patients (3, 9 -14). In spontaneous experimental models of IDDM, most data dealing with glucose homeostasis at the prediabetic stage demonstrated a lower insulin response to glucose in both BB rats (15-21) and NOD mice (22)(23)(24)(25)(26). However, in the BB rat in particular, the existence of hyperactive ␤-cells at the prediabetic stage can be suggested on the...

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Section: Nsulin-dependent Diabetes Mellitus (Iddm) or Typementioning

confidence: 99%

Section: Nsulin-dependent Diabetes Mellitus (Iddm) or Typementioning

confidence: 99%

Glucose Homeostasis in the Nonobese Diabetic Mouse at the Prediabetic Stage¹

et al. 1998

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“…However, vanadium treatment was demonstrated to improve pancreatic insulin content in STZ-induced diabetic rats [16,17]. It has been reported that the residual insulin reserves in diabetic rats following vanadium treatment were 5.6 fold [17] to 7.8 fold [16] higher than in untreated diabetic animals, suggesting that a reduction in insulin biosynthesis and secretion can render beta-cells less susceptible to cytotoxic events [7,18,19].…”

Section: Figmentioning

confidence: 99%

The influence of sodium metavanadate on the process of diabetogenesis in BB rats

Cheţa¹,

Orasanu²,

Nicolaie

et al. 2003

J Cellular Molecular Medi

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Vanadium has been shown to be beneficial in the oral treatment of animal models of type 1 and type 2 diabetes. The aim of the study was to evaluate the short‐term effects of sodium metavanadate in prediabetic BB‐DP rats. To do this, 96 rats were divided into 4 equal groups. Groups VI, V2, V3 were treated with sodium metavanadate (0.1, 0.2 and 0.3 mg/ml respectively) and sodium chloride (0.5 mg/ml) in drinking water for 7 days. Group C received only sodium chloride (0.5 mg/ml). Blood glucose (BG), glycosuria, ketonuria, body weight and insulinemia were determined. The age of onset of diabetes was significantly higher for groups V2, V3 compared to group C, (p < 0.05) and depends on the metavanadate concentration (V3 vs. V1, p=0.006). The incidence of diabetes was lower in the rats treated with metavanadate than in the control group, but this difference was not statistically significant. In diabetic rats, the BG at the onset was higher in group C than in groups V, p < 0.05. Insulinemia, at the onset of the treatment as well as immediately after its cessation showed a drop in the treatment groups, proportionally to the dosage of vanadium, but later increased slowly and continuously until the end of the experiment. In conclusion, metavanadate delays the development of diabetes in BB‐DP rats, but does not prevent its onset. A milder form of diabetes occurs in diabetic rats treated with metavanadate. The effects depend on the metavanadate concentration and 0.2 mg/ml is preferable.

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Partial preservation of pancreatic β-cells by vanadian: Evidence for long-term amelioration of diabetes

Cam

McNeill

1997

Metabolism

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The remission concept in type 1 diabetes and its significance in immune intervention

Cited by 5 publications

References 72 publications

Glucose Homeostasis in the Nonobese Diabetic Mouse at the Prediabetic Stage¹

Glucose Homeostasis in the Nonobese Diabetic Mouse at the Prediabetic Stage¹

The influence of sodium metavanadate on the process of diabetogenesis in BB rats

Partial preservation of pancreatic β-cells by vanadian: Evidence for long-term amelioration of diabetes

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The remission concept in type 1 diabetes and its significance in immune intervention

Cited by 5 publications

References 72 publications

Glucose Homeostasis in the Nonobese Diabetic Mouse at the Prediabetic Stage1

Glucose Homeostasis in the Nonobese Diabetic Mouse at the Prediabetic Stage1

The influence of sodium metavanadate on the process of diabetogenesis in BB rats

Partial preservation of pancreatic β-cells by vanadian: Evidence for long-term amelioration of diabetes

Contact Info

Product

Resources

About

Glucose Homeostasis in the Nonobese Diabetic Mouse at the Prediabetic Stage¹

Glucose Homeostasis in the Nonobese Diabetic Mouse at the Prediabetic Stage¹