2011
DOI: 10.1098/rstb.2011.0080
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The Renaissance or the cuckoo clock

Abstract: ‘…in Italy, for thirty years under the Borgias, they had warfare, terror, murder and bloodshed, but they produced Michelangelo, Leonardo da Vinci and the Renaissance. In Switzerland, they had brotherly love, they had five hundred years of democracy and peace—and what did that produce? The cuckoo clock’. Orson Welles as Harry Lime : The Third Man Orson Welles might have been a little unfair on the Swi… Show more

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Cited by 19 publications
(24 citation statements)
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References 115 publications
(138 reference statements)
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“…Thus, activation of mitotic Cdk1 and inactivation of Cdk1 opposing phosphatases constitute the central elements in this switch system . A complex network of feedback control between Cdk1, its activators, and inhibitors has evolved that ensures a rapid, yet stable induction of the mitotic state . Equally important is to ensure that the switch is triggered at the right time.…”
Section: The Mitotic Trigger Is An Irreversible Cellular Switchmentioning
confidence: 99%
“…Thus, activation of mitotic Cdk1 and inactivation of Cdk1 opposing phosphatases constitute the central elements in this switch system . A complex network of feedback control between Cdk1, its activators, and inhibitors has evolved that ensures a rapid, yet stable induction of the mitotic state . Equally important is to ensure that the switch is triggered at the right time.…”
Section: The Mitotic Trigger Is An Irreversible Cellular Switchmentioning
confidence: 99%
“…The acquired reliance upon Plo1 signalling at the fission yeast SPB in some environmental contexts resonates with the addiction of human cell lines to Plk1 activity during recovery from DNA-checkpoint-dependent cell cycle arrest [47,48] and the emergence of Cdk1-cyclin B signalling from human centrosomes [17] to suggest that spatial control plays a key role in co-ordinating cell division and environmental requirements throughout eukaryotes [49].…”
Section: Tor (Target Of Rapamycin) Kinase Control Of Stress Response mentioning
confidence: 99%
“…Pines & Hagan [17] revisit many of the points raised in the preceding articles from a wide-ranging perspective, but they go on to stress the importance of intensely local conditions controlling physically distant processes. A particular concern of theirs is the spindle pole in fission yeast and its role as the place where a commitment to mitosis is made first, and the centrosome in animal cells, which they argue plays a central role in the control of mitotic entry.…”
Section: Introductionmentioning
confidence: 99%