The reproductive toxicity on the rotifer Brachionus plicatilis induced by BDE-47 and studies on the effective mechanism based on antioxidant defense system changes

Wang, Hong; Tang, Xuexi; Sha, Jingjing; Chen, Hongmei; Sun, Tianli; Wang, You

doi:10.1016/j.chemosphere.2015.03.090

Cited by 68 publications

(15 citation statements)

References 69 publications

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“…IL-1 β has the ability to induce consecutive inflammatory response, such as activating NF- κ B and downstream molecules iNOS and COX-2 [ 3 ]. Increasing knowledge shows that BDE-47 elevates ROS generation via depletion of the expressions of antioxidant response genes and the content of glutathione (GSH) [ 30 , 34 ]. Excessive ROS leads to the occurrence and development of inflammatory response [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Troxerutin Protects Kidney Tissue against BDE‐47‐Induced Inflammatory Damage through CXCR4‐TXNIP/NLRP3 Signaling

Shan

Zheng

Han

et al. 2018

Oxidative Medicine and Cellular Longevity

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2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47) induces oxidative stress in kidney cells, but the underlying mechanism remains poorly understood. Troxerutin, a natural flavonoid, has potential antioxidant and anti-inflammatory efficacy. In this study, we assessed the effect of troxerutin on kidney damage caused by BDE-47 and investigated the underlying mechanism. The results showed troxerutin reduced reactive oxygen species (ROS) level and urine albumin-to-creatinine ratio (ACR), decreased the activities of inflammatory factors including cyclooxygenase-2 (COX-2), induced nitric oxide synthase (iNOS) and nuclear factor kappa B (NF-κB) in the kidney tissues of BDE-47-treated mice. Furthermore, troxerutin significantly weakened the expression of kidney NLRP3 inflammasome containing NLRP3, ASC, and caspase-1, contributing to the decline of IL-1β. Additionally, troxerutin inhibited the increased protein level of stromal-derived factor-1(SDF-1), C-X-C chemokine ligand 12 receptor 4 (CXCR4), and thioredoxin interaction protein (TXNIP) caused by BDE-47. Specifically, the immunoprecipitation assay indicated that there was a direct interaction between CXCR4 and TXNIP. CXCR4 siRNA and TXNIP siRNA also decreased the inflammatory damage, which was similar to the action of troxerutin. Our data demonstrated that troxerutin regulated the inflammatory lesions via CXCR4-TXNIP/NLRP3 inflammasome in the kidney of mice induced by BDE-47.

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Section: Discussionmentioning

confidence: 99%

Troxerutin Protects Kidney Tissue against BDE‐47‐Induced Inflammatory Damage through CXCR4‐TXNIP/NLRP3 Signaling

Shan

Zheng

Han

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…It is well known that a balance exists between the production and elimination of ROS in organisms under normal circumstances, and the antioxidant system plays an essential role in keeping that balance. However, that balance would be disturbed when exposed to stresses 34 . We found an increase in the ROS level and an alteration of the main components of the antioxidant system with acidification exposure, and the relationship between them was also quantitatively analysed.…”

Section: Discussionmentioning

confidence: 99%

Seawater acidification induced immune function changes of haemocytes in Mytilus edulis: a comparative study of CO2 and HCl enrichment

Sun

Tang

Jiang

et al. 2017

Sci Rep

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The present study was performed to evaluate the effects of CO2− or HCl-induced seawater acidification (pH 7.7 or 7.1; control: pH 8.1) on haemocytes of Mytilus edulis, and the changes in the structure and immune function were investigated during a 21-day experiment. The results demonstrated that seawater acidification had little effect on the cellular mortality and granulocyte proportion but damaged the granulocyte ultrastructure. Phagocytosis of haemocytes was also significantly inhibited in a clearly concentration-dependent manner, demonstrating that the immune function was affected. Moreover, ROS production was significantly induced in both CO2 and HCl treatments, and four antioxidant components, GSH, GST, GR and GPx, had active responses to the acidification stress. Comparatively, CO2 had more severe destructive effects on haemocytes than HCl at the same pH level, indicating that CO2 stressed cells in other ways beyond the increasing H+ concentration. One possible explanation was that seawater acidification induced ROS overproduction, which damaged the ultrastructure of haemocytes and decreased phagocytosis.

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“…The rotifer B. plicatilis used in this experiment was obtained by hatching resting eggs that were provided by the College of Fisheries of the Ocean University of China. The hatching conditions were the same as those in our previous description [ 37 , 59 ]. After hatching, the rotifers were cultivated in an illuminating incubator with a 12 h: 12 h light: dark cycle at (25 ± 1) °C, 80 μmol photons/(m 2 ·s).…”

Section: Methodsmentioning

confidence: 99%

“…Brachionus plicatilis is one of the most important species of marine herbivore zooplankton and was the model organism for ecotoxicological assessment. Our previous studies had documented that the reproduction of B. plicatilis was sensitive to exogenous stress, and the involvement of ROS was partially responsible for reproductive toxicity [ 35 , 36 , 37 , 38 ]. We thus preformed the present study to further elucidate the possible toxic mechanism of K. mikimotoi , and the questions we were interested in were as follows: Does K. mikimotoi exert a hemolytic allelopathic effect on co-cultured zooplankton, and is the allelopathic effect ROS-dependent?…”

Section: Introductionmentioning

confidence: 99%

Using the Marine Rotifer Brachionus plicatilis as an Endpoint to Evaluate Whether ROS-Dependent Hemolytic Toxicity Is Involved in the Allelopathy Induced by Karenia mikimotoi

Sun³

et al. 2018

Toxins

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The toxic effects of the typically noxious bloom-forming dinoflagellate Karenia mikimotoi were studied using the allelopathic experimental system under controlled laboratory conditions. The potency of intact cell suspensions with whole cells, cell-free culture filtrate in different growth phases, and lysed cells with ultrasonication were compared, and the growth and reproduction of the marine rotifer Brachionus plicatilis were used as endpoints to evaluate toxic differences. The intact cell suspension resulted the most significant growth inhibition, including lethality, on the growth of B. plicatilis (p < 0.05). Lysed culture medium treated with ultrasonication and the cell-free culture filtrates at either the exponential or stationary phase exhibited limited negative impacts compared to the control according to changes in the population growth rate (r) and survival rate (p > 0.05). Reproduction presented a similar tendency to change, and the number of eggs produced per individual, as well as spawning period decreased in the whole cell and lysed cell suspensions. The key parameters in the lift table include the net reproductive rate (R0) and the intrinsic rate of increase (rm), which were more sensitive to treatment and were significantly suppressed compared to that of the control. The addition of the ROS inhibitor N-acetylcysteine (NAC) could not change the growth or reproduction patterns. Moreover, substantial hemolytic toxicity was found in the treatment of the intact cell suspension (p < 0.05), while limited toxicity was found in other treatments compared to that of the control. K. mikimotoi was speculated to secrete allelopathic substances onto the cell surface, and direct cell contact was necessary for allelopathic toxicity in B. plicatilis. Reactive oxygen species (ROS)-independent hemolytic toxicity was assumed to be the explanation for what was observed.

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The reproductive toxicity on the rotifer Brachionus plicatilis induced by BDE-47 and studies on the effective mechanism based on antioxidant defense system changes

Cited by 68 publications

References 69 publications

Troxerutin Protects Kidney Tissue against BDE‐47‐Induced Inflammatory Damage through CXCR4‐TXNIP/NLRP3 Signaling

Troxerutin Protects Kidney Tissue against BDE‐47‐Induced Inflammatory Damage through CXCR4‐TXNIP/NLRP3 Signaling

Seawater acidification induced immune function changes of haemocytes in Mytilus edulis: a comparative study of CO2 and HCl enrichment

Using the Marine Rotifer Brachionus plicatilis as an Endpoint to Evaluate Whether ROS-Dependent Hemolytic Toxicity Is Involved in the Allelopathy Induced by Karenia mikimotoi

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