The retinal nerve fibre layer thickness in glaucomatous hydrophthalmic eyes assessed by scanning laser polarimetry with variable corneal compensation in comparison with age‐matched healthy children

Hlozánek, M; J, Osmera; Lezatková, P; Sedláčková, Petra; Filouš, A

doi:10.1111/j.1755-3768.2011.02133.x

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…46 The outer nuclear layer is relatively thicker on the nasal edge of the disc (where it is 8-9 cells thick) compared to the 4 rows thick at the temporal edge. 46 In all studies the ocular status was normal except for Hlozanek et al, 18 Rolle et al, 21 Lu et al, 29 Mrugacz and Bakunowicz-Lazarczyk, 39 where eyes were glaucomatous and Repka et al, 35 where eyes had amblyopia. NFL, nerve fibre layer; NR, not reported; OCT, optical coherence tomography; SD, standard deviation.…”

Section: Outer Nuclear Layermentioning

confidence: 91%

A review of the human retina with emphasis on nerve fibre layer and macula thicknesses

Mashige

Oduntan

2016

African Vision and Eye Health

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The retina is the innermost neural layer of the eye, and is the site of transformation of light energy into a neural signal. Knowledge and assessment of the human retinal structural parameters are important for the appropriate diagnosis and management of various ocular diseases. For instance, potentially blinding eye diseases, such as glaucoma and age-related macula degeneration, cause structural changes in the retina. Clinical evidence with ocular coherence tomography also suggests that eyes with glaucoma lose retinal nerve fibre layer and ganglion cells axons before loss of visual function. These losses appear as a visible change in the optic nerve head and can be seen before visual field abnormalities are noticed by the patient. This review discusses certain aspects (anatomical structures, structural changes with eye diseases and assessment methods) involving the human retina, their clinical importance and factors that may influence them. The content of this article will be useful to optometrists and ophthalmologists who assess these parameters in normal patients as well as in those with eye conditions such as glaucoma.Keywords: Retinal parameters; optic disc; nerve fibre layer thickness; macula thickness; glaucoma

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Section: Outer Nuclear Layermentioning

confidence: 91%

A review of the human retina with emphasis on nerve fibre layer and macula thicknesses

Mashige

Oduntan

2016

African Vision and Eye Health

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“…This eye disease is not only a problem in less-developed countries, but even in Western Europe it is the second most common cause of irreversible vision loss after age-related macular degeneration [1]. It leads to thinning of the retinal nerve fiber layers, causes progressive optic nerve damage, and causes gradual loss of sight in both adults and children [2]. Pharmaceutical and surgical treatment, focusing on the management of intraocular pressure (IOP), can significantly slow the adverse changes and prevent the irreversible loss of visual functions [3].…”

Section: Introductionmentioning

confidence: 99%

Novel Biomaterials in Glaucoma Treatment

Klézlová,

Bulíř,

Klápšťová

et al. 2024

Biomedicines

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Glaucoma is a significant cause of blindness worldwide, and its treatment remains challenging. The disease progressively leads to damage to the optic disc and thus loss of visual acuity and visual field. High intraocular pressure (IOP) is a common risk factor. There are three major methods to treat this disease: topical, laser, and surgical. None of these are completely satisfactory; therefore, alternatives using new biomaterials are being sought. Since biomaterial engineering has experienced significant growth in recent decades, its products are gradually being introduced to various branches of medicine, with the exception of ophthalmology. Biomaterials, such as glaucoma drainage implants, have been successfully used to treat glaucoma. There is significant ongoing research on biomaterials as drug delivery systems that could overcome the disadvantages of topical glaucoma treatment, such as poor intraocular penetration or frequent drug administration. This article summarizes the use of novel biomaterials for glaucoma treatment presented in the literature. The literature search was based on articles published in English on PubMed.gov, Cochranelibrary.com, and Scopus.com between 2018 and 2023 using the following term “biomaterials in glaucoma.” A total of 103 published articles, including twenty-two reviews, were included. Fifty-nine articles were excluded on the basis of their titles and abstracts.

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“…Few studies [7][8][9][10] have been published that describe changes in buphthalmic eyes and histologic changes in the particular corneal layers in patients with buphthalmos. Corneal confocal microscopy allows study of the human cornea in vivo at the microscopic level.…”

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confidence: 99%

Corneal Changes Assessed Using Confocal Microscopy in Patients With Unilateral Buphthalmos

Mahelková

Filouš

Odehnal

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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Citation: Mahelková G, Filouš A, Odehnal M, Cendelín J. Corneal changes assessed using confocal microscopy in patients with unilateral buphthalmos. Invest Ophthalmol Vis Sci. 2013;54:4048-4053. DOI:10. 1167/iovs.12-11165 PURPOSE. To compare corneal structures in buphthalmic eyes and healthy eyes in patients with unilateral congenital glaucoma using a corneal confocal microscope.METHODS. Ten patients with unilateral buphthalmos (mean 6 SD age, 14.85 6 5.12 years) were examined using corneal confocal microscopy. The cell density and cell area of endothelial cells and superficial and basal epithelial cells and the number of keratocytes were evaluated.RESULTS. There was no significant difference between the cell density of superficial epithelial cells in buphthalmic eyes relative to healthy eyes (P ¼ 0.1944). The cell density of basal epithelial cells was significantly higher (P ¼ 0.0234) and the cell area was significantly smaller (P ¼ 0.0181) in buphthalmic eyes relative to healthy eyes. There was no difference between the number of keratocytes in buphthalmic eyes and healthy eyes in the anterior stroma (P ¼ 0.273) or in the posterior stroma (P ¼ 0.0799). The cell density of endothelial cells was significantly lower and the cell area was significantly larger in buphthalmic eyes relative to healthy eyes (P ¼ 0.0009). CONCLUSIONS.We demonstrated a lower cell density of endothelial cells in buphthalmic eyes. We found no differences in keratocyte density between the buphthalmic eyes and healthy eyes. The cell density of basal epithelial cells was higher in buphthalmic eyes. These differences could be due to buphthalmos or due to the previous surgical and medical therapies. Monitoring of these changes could help to contribute to accurate assessments regarding future ocular surgical procedures.

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The retinal nerve fibre layer thickness in glaucomatous hydrophthalmic eyes assessed by scanning laser polarimetry with variable corneal compensation in comparison with age‐matched healthy children

Cited by 4 publications

References 20 publications

A review of the human retina with emphasis on nerve fibre layer and macula thicknesses

A review of the human retina with emphasis on nerve fibre layer and macula thicknesses

Novel Biomaterials in Glaucoma Treatment

Corneal Changes Assessed Using Confocal Microscopy in Patients With Unilateral Buphthalmos

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