2024
DOI: 10.1242/jcs.261949
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The retromer and retriever systems are conserved and differentially expanded in parabasalids

Abhishek Prakash Shinde,
Jitka Kučerová,
Joel Bryan Dacks
et al.

Abstract: Early Endosomes sort transmembrane cargo whether for lysosomal degradation or retrieval to the plasma membrane or the Golgi complex. Endosomal retrieval in eukaryotes is governed by the anciently homologous Retromer or Retriever complexes. Each comprises a core tri-protein subcomplex, membrane-deformation proteins, and interacting partner complexes, together retrieving a variety of known cargo proteins. Trichomonas vaginalis; a sexually transmitted human parasite uses the endomembrane system for pathogenesis. … Show more

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