The right profile: Mismatch negativity in schizophrenia with and without auditory hallucinations as measured by a multi-feature paradigm

Fisher, Derek J.; Labelle, Alain; Knott, Verner

doi:10.1016/j.clinph.2007.12.005

Cited by 78 publications

(66 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fisher and colleagues 49,50 showed correlations between MMN and the severity of the specific positive symptom of auditory verbal hallucinations (AVH). Our data pointed to a more general relationship of MMN and positive symptoms, as well as with paranoia.…”

Section: Healthy Mmn In First Hospitalized Schizophreniamentioning

confidence: 99%

Pitch and Duration Mismatch Negativity and Premorbid Intellect in the First Hospitalized Schizophrenia Spectrum

Salisbury

Polizzotto

Nestor

et al. 2016

SCHBUL

View full text Add to dashboard Cite

Mismatch negativity (MMN) is a robustly abnormal brainwave in chronically ill schizophrenia that has generated interest as a disease presence biomarker. Reports of MMN reduction in first-episode schizophrenia have been equivocal, raising uncertainty about its reduction at first psychotic break. Here we tested 29 schizophrenia-spectrum participants under 1 year from their first hospitalization for psychosis and 40 age-, gender-, parental socioeconomic status-, and Wechsler Adult Intelligence Scales III Information-matched healthy controls on both pitch and duration MMN. Participants performed a visual checkerboard tracking task while standard (1 kHz, 50 ms, 80%), pitch-deviant (1.2 kHz, 50 ms, 10%) and duration-deviant (1 kHz, 100 ms, 10%) tones were presented over headphones (75 dB) and EEG was recorded. Independent component analysis was used to remove eye movements and visual stimulus processing activity. Groups did not differ in pitch MMN or duration MMN amplitudes. Smaller pitch and duration MMN amplitudes were associated with lower estimates of premorbid intellect in all participants and independently with greater positive symptoms in first hospitalized schizophrenia. Overall MMN reduction was not present in these relatively high functioning individuals at the first episode of schizophrenia, and therefore is not a good disease presence biomarker for this sample. Future research is warranted to determine the degree of MMN reduction at the first episode of psychosis across a greater range of cognitive impairment, the utility of MMN as an indicator of risk or diagnosis, and its role for understanding pathophysiological mechanisms in emerging psychosis.

show abstract

Section: Healthy Mmn In First Hospitalized Schizophreniamentioning

confidence: 99%

Pitch and Duration Mismatch Negativity and Premorbid Intellect in the First Hospitalized Schizophrenia Spectrum

Salisbury

Polizzotto

Nestor

et al. 2016

SCHBUL

View full text Add to dashboard Cite

show abstract

“…The narrow band pass, previously used in a study of the Optimal MMN (Fisher et al, 2008), eliminates any extraneous high-frequency activity. MMN difference waveforms were derived by performing point-by-point subtraction of the standard stimulus values from those elicited by the deviant stimulus, and MMNs were assessed by quantifying peak negative amplitudes within a window of 80-220 ms. MMN peaks for each individual participant were picked as the most negative point within each condition's respective analysis window and output was the average within five voltage points (10 ms) to the left and right of the peak amplitude.…”

Section: Eeg Recording and Erp Computationmentioning

confidence: 99%

“…Given this advantage over the traditional oddball design, the multi-feature MMN paradigm has been employed extensively in clinical research, notably to characterize MMN in schizophrenia (Fisher et al, 2008;Thonnessen et al, 2008), post-traumatic stress disorder (Menning et al, 2008) and Asperger syndrome (Kujala et al, 2010). However, of these five deviant types, the frequency, duration and intensity deviants (obtained from auditory oddball paradigms) are most often reported in MMN literature and in some studies it may be useful to have access to a shorter (e.g.…”

Section: Introductionmentioning

confidence: 99%

Effects of deviant probability on the ‘optimal’ multi-feature mismatch negativity (MMN) paradigm

Fisher

Grant

Smith

et al. 2011

International Journal of Psychophysiology

Self Cite

View full text Add to dashboard Cite

“…In children, the duration of the experimental session plays an important role for data quality. Previous studies investigated whether the recently reported multi-feature paradigm could be used for auditory discrimination-accuracy profiles in adults [Näätänen et al, 2004;Kujala et al, 2006Kujala et al, , 2007Pakarinen et al, 2007;Fisher et al, 2008;Kwon et al, 2009], and the present study is the first to apply the multi-feature paradigm in school-aged children. If applicable, this paradigm could be very useful in assessing the perceptual accuracy of children for several sound-feature dimensions.…”

Section: Introductionmentioning

confidence: 98%

No effects of mobile phone use on cortical auditory change‐detection in children: An ERP study

Kwon

Huotilainen

Шестакова

et al. 2009

Bioelectromagnetics

View full text Add to dashboard Cite

We investigated the effect of mobile phone use on the auditory sensory memory in children. Auditory event-related potentials (ERPs), P1, N2, mismatch negativity (MMN), and P3a, were recorded from 17 children, aged 11-12 years, in the recently developed multi-feature paradigm. This paradigm allows one to determine the neural change-detection profile consisting of several different types of acoustic changes. During the recording, an ordinary GSM (Global System for Mobile Communications) mobile phone emitting 902 MHz (pulsed at 217 Hz) electromagnetic field (EMF) was placed on the ear, over the left or right temporal area (SAR(1g) = 1.14 W/kg, SAR(10g) = 0.82 W/kg, peak value = 1.21 W/kg). The EMF was either on or off in a single-blind manner. We found that a short exposure (two 6 min blocks for each side) to mobile phone EMF has no statistically significant effects on the neural change-detection profile measured with the MMN. Furthermore, the multi-feature paradigm was shown to be well suited for studies of perception accuracy and sensory memory in children. However, it should be noted that the present study only had sufficient statistical power to detect a large effect size.

show abstract

The right profile: Mismatch negativity in schizophrenia with and without auditory hallucinations as measured by a multi-feature paradigm

Cited by 78 publications

References 68 publications

Pitch and Duration Mismatch Negativity and Premorbid Intellect in the First Hospitalized Schizophrenia Spectrum

Pitch and Duration Mismatch Negativity and Premorbid Intellect in the First Hospitalized Schizophrenia Spectrum

Effects of deviant probability on the ‘optimal’ multi-feature mismatch negativity (MMN) paradigm

No effects of mobile phone use on cortical auditory change‐detection in children: An ERP study

Contact Info

Product

Resources

About