The right ventricle under pressure: Anatomy and imaging in sickness and health

Stubbs, Harrison A.; MacLellan, Alexander; Lua, Stephanie; Dormand, Helen; Church, Colin

doi:10.1111/joa.13654

Cited by 3 publications

(3 citation statements)

References 53 publications

(72 reference statements)

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Section: Introductionmentioning

confidence: 61%

“…As has been stated on several previous occasions, the right ventricle is very much the poor relation of its left ventricular counterpart (Ho & Nihoyannopoulos, 2006 ; Stubbs et al, 2023 ; Wang et al, 2019 ). This does not detract, however, from its integral role in supporting the normal pulmonary circulation.…”

Section: Introductionmentioning

confidence: 70%

“…Although there are subtle differences in the postnatal morphology of the human and murine hearts, the similarities of the developmental processes are sufficiently coherent to permit direct comparisons between the two species. As we emphasised in our introduction, the right ventricle has usually been seen as the poor relation of its left ventricular counterpart (Ho & Nihoyannopoulos, 2006 ; Stubbs et al, 2023 ; Wang et al, 2019 ). It was initially described as possessing two rather than three components.…”

Section: Discussionmentioning

confidence: 99%

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Revisiting the anatomy of the right ventricle in the light of knowledge of its development

Crucean,

Spicer,

Tretter

et al. 2023

Journal of Anatomy

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Controversies continue regarding several aspects of the anatomy of the morphologically right ventricle. There is disagreement as to whether the ventricle should be assessed in bipartite or tripartite fashion, and the number of leaflets to be found in the tricuspid valve. In particular, there is no agreement as to whether a muscular outlet septum is present in the normally constructed heart, nor how many septal components are to be found during normal development. Resolving these issues is of potential significance to those investigating and treating children with congenitally malformed hearts. With all these issues in mind, we have revisited our own experience in investigating the development and morphology of the normal right ventricle. To assess development, we have examined a large number of datasets, prepared by both standard and episcopic microscopy, from human and murine embryos. In terms of gross anatomy, we have compared dissections of normal autopsied hearts with virtual dissections of datasets prepared using computed tomography. Our developmental and postnatal studies, taken together, confirm that the ventricle is best assessed in tripartite fashion, with the three parts representing its inlet, apical trabecular, and outlet components. The ventricular septum, however, has only muscular and membranous components. The muscular part incorporates a small component derived from the muscularised fused proximal outflow cushions, but this part cannot be distinguished from the much larger part that is incorporated within the free‐standing muscular infundibular sleeve. We confirm that the tricuspid valve itself has three components, which are located inferiorly, septally, and antero‐superiorly.

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Section: Introductionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Revisiting the anatomy of the right ventricle in the light of knowledge of its development

Crucean,

Spicer,

Tretter

et al. 2023

Journal of Anatomy

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The right ventricle under pressure: Anatomy and imaging in sickness and health

et al. 2022

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The right ventricle (RV) is an important structure which serves a multitude of vital physiological functions in health. For many years, the left ventricle has dominated the focus of understanding in both biology and pathophysiology and the RV was felt to be more of a passive structure which rarely had an effect on disease states. However, it is increasingly recognised that the RV is essential to the homoeostasis of normal physiology and disturbances in RV structure and function have a substantial effect on patient outcomes. Indeed, the prognosis of diseases of lung diseases affecting the pulmonary vasculature and left heart disease is intimately linked to the function of the right ventricle. This review sets out to describe the developmental and anatomical complexities of the right ventricle while exploring the modern techniques employed to image and understand its function from a clinical perspective.

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