2022
DOI: 10.1016/j.celrep.2022.110434
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The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity

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Cited by 26 publications
(25 citation statements)
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“…DDX60 overexpression, a gene upregulated after viral infections, which has been shown to bind RIG-I, increasing RIG-I activation, decreased VSV and poliovirus replication ( 60 ). Similarly, DHX15, a gene upregulated after viral infections, which has been shown to bind RIG-I, increasing RIG-I activation, increased encephalomyocarditis virus (EMCV) replication ( 61 ), and the helicases DHX16 and DDX6, two proteins which recognize specific viral RNA to trigger RIG-I-dependent innate antiviral immunity negatively affect IAV, Zika and SARS-CoV-2 ( 62 ) and enterovirus ( 63 ) replication.…”
Section: Discussionmentioning
confidence: 99%
“…DDX60 overexpression, a gene upregulated after viral infections, which has been shown to bind RIG-I, increasing RIG-I activation, decreased VSV and poliovirus replication ( 60 ). Similarly, DHX15, a gene upregulated after viral infections, which has been shown to bind RIG-I, increasing RIG-I activation, increased encephalomyocarditis virus (EMCV) replication ( 61 ), and the helicases DHX16 and DDX6, two proteins which recognize specific viral RNA to trigger RIG-I-dependent innate antiviral immunity negatively affect IAV, Zika and SARS-CoV-2 ( 62 ) and enterovirus ( 63 ) replication.…”
Section: Discussionmentioning
confidence: 99%
“…DHX15 has been characterized as a sensor for several enteric RNA viruses and control production of IFN-β, IFN-λ3, and IL-18 in IECs ( Kenta et al., 2014 ; Lu et al., 2014 ; Xing et al., 2021 ). Recent study identified DHX16 recognizes specific viral RNA to trigger RIG-I-dependent IFN-β production ( Hage et al., 2022 ).…”
Section: Discussionmentioning
confidence: 99%
“…not covalently linked to a protein). This interaction with unanchored poly-ubiquitin chains promoted DHX16 interaction with RIG-I and activated downstream signalling [126]. DHX16 depletion in mice showed that DHX16 was necessary for optimal IFN production in vivo , ISG induction and protection against IAV and other viruses, such as ZIKV and SARS-CoV-2 [126].…”
Section: Dhx16mentioning
confidence: 99%
“…This interaction with unanchored poly-ubiquitin chains promoted DHX16 interaction with RIG-I and activated downstream signalling [126]. DHX16 depletion in mice showed that DHX16 was necessary for optimal IFN production in vivo , ISG induction and protection against IAV and other viruses, such as ZIKV and SARS-CoV-2 [126]. Moreover, the E3-ubiquitine ligase TRIM6, which was known to stimulate IFN production by activating IKKε through the synthesis of unanchored K48-polyubiquitin chains [127], was shown to interact with DHX16 and to increase its interaction with unanchored polyubiquitin chains, thereby stimulating its activity.…”
Section: Dhx16mentioning
confidence: 99%