The RND efflux pump EefABC is highly conserved within lineages ofE. colicommonly associated with infection
Hannah L. Pugh,
Elizabeth M. Darby,
Leah Burgess
et al.
Abstract:Tripartite resistance-nodulation-division (RND) efflux pumps confer multidrug resistance (MDR) in Gram-negative bacteria and are critical for many physiological functions including virulence and biofilm formation. The common laboratory strain ofE. coli,K-12 MG1655 has six recognised RND transporters participating in tripartite pump formation (AcrB, AcrD, AcrF, CusA, MdtBC, and MdtF). However, by studying >20,000E. coligenomes we show thatE. colibelonging to phylogroups B2, D, E, F and G, which are commonly … Show more
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