The Road to Mitochondrial Gene Transfer: Follow the Middle Lane

Bredenoord, AL; Hyun, Insoo

doi:10.1038/mt.2015.79

Cited by 7 publications

(5 citation statements)

References 4 publications

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“…Ethical issues under discussion include the acceptability of modifying the human genome [ 179 ], the role of the mitochondrial donor as a contributor to the 'parental project' (i.e., concept of 'three parent families' in the lay press) and implications for offspring identity, the proportionality of developing MRT technology as based on a view of the importance of genetic parenthood, and finding a balance between taking appropriate precautions and hampering innovation [ 180 , 181 , 182 , 183 ].…”

Section: Introductionmentioning

confidence: 99%

Recent developments in genetics and medically assisted reproduction: from research to clinical applications

et al. 2017

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Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September 2016, the expert panel met for the third time. The topics discussed highlighted important issues covering the impacts of expanded carrier screening, direct-to-consumer genetic testing, voiding of the presumed anonymity of gamete donors by advanced genetic testing, advances in the research of genetic causes underlying male and female infertility, utilisation of massively parallel sequencing in preimplantation genetic testing and non-invasive prenatal screening, mitochondrial replacement in human oocytes, and additionally, issues related to cross-generational epigenetic inheritance following IVF and germline genome editing. The resulting paper represents a consensus of both professional societies involved.

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Section: Introductionmentioning

confidence: 99%

Recent developments in genetics and medically assisted reproduction: from research to clinical applications

et al. 2017

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“…Ethical issues under discussion include the acceptability of modifying the human genome (Palacios-González, 2017), the role of the mitochondrial donor as a contributor to the ‘parental project’ (i.e. concept of ‘three parent families’ in the lay press) and implications for offspring identity, the proportionality of developing MRT technology as based on a view of the importance of genetic parenthood, and finding a balance between taking appropriate precautions and hampering innovation (Nuffield Council on Bioethics, 2012; Bredenoord and Hyun, 2015; Fogleman et al , 2016; Gómez-Tatay et al , 2017).…”

Section: Mitochondria: From Diagnosis To Treatmentmentioning

confidence: 99%

Recent developments in genetics and medically-assisted reproduction: from research to clinical applications†‡

Harper

Aittomäki

Borry

et al. 2017

Human Reproduction Open

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Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September 2016, the expert panel met for the third time. The topics discussed highlighted important issues covering the impacts of expanded carrier screening, direct-to-consumer genetic testing, voiding of the presumed anonymity of gamete donors by advanced genetic testing, advances in the research of genetic causes underlying male and female infertility, utilisation of massively-parallel sequencing in preimplantation genetic testing and non-invasive prenatal screening, mitochondrial replacement in human oocytes, and additionally, issues related to cross-generational epigenetic inheritance following IVF and germline genome editing. The resulting paper represents a consensus of both professional societies involved.

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“…As Bredenoord and Hyun (2015) argue, when discussing whether the USA should follow the UK’s lead in permitting MST/PNT, ‘The bold leap from bench to bedside needs sufficient preclinical evidence and careful, long-term interdisciplinary research, including more ethics research’ (2015, 976). They recommend that the USA should take a more cautious path and argue, ‘A cautionary approach means that a wide variety of concerns should be taken seriously – wider than safety and efficacy alone’; the need is to find a balance between ‘taking appropriate precautions and not unnecessarily hampering innovation’ (2015,976).…”

Section: Concluding Commentsmentioning

confidence: 99%

Sharpening the cutting edge: additional considerations for the UK debates on embryonic interventions for mitochondrial diseases

Haimes

Taylor

2017

Life Sci Soc Policy

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In October 2015 the UK enacted legislation to permit the clinical use of two cutting edge germline-altering, IVF-based embryonic techniques: pronuclear transfer and maternal spindle transfer (PNT and MST). The aim is to use these techniques to prevent the maternal transmission of serious mitochondrial diseases. Major claims have been made about the quality of the debates that preceded this legislation and the significance of those debates for UK decision-making on other biotechnologies, as well as for other countries considering similar legislation. In this article we conduct a systematic analysis of those UK debates and suggest that claims about their quality are over-stated. We identify, and analyse in detail, ten areas where greater clarity, depth and nuance would have produced sharper understandings of the contributions, limitations and wider social impacts of these mitochondrial interventions. We explore the implications of these additional considerations for (i) the protection of all parties involved, should the techniques transfer to clinical applications; (ii) the legitimacy of focussing on short-term gains for individuals over public health considerations, and (iii) the maintenance and improvement of public trust in medical biotechnologies. We conclude that a more measured evaluation of the content and quality of the UK debates is important and timely: such a critique provides a clearer understanding of the possible, but specific, contributions of these interventions, both in the UK and elsewhere; also, these additional insights can now inform the emerging processes of implementation, regulation and practice of mitochondrial interventions.

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The Road to Mitochondrial Gene Transfer: Follow the Middle Lane

Cited by 7 publications

References 4 publications

Recent developments in genetics and medically assisted reproduction: from research to clinical applications

Recent developments in genetics and medically assisted reproduction: from research to clinical applications

Recent developments in genetics and medically-assisted reproduction: from research to clinical applications†‡

Sharpening the cutting edge: additional considerations for the UK debates on embryonic interventions for mitochondrial diseases

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