2022
DOI: 10.3389/fncel.2022.893857
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The Role and Modulation of Spinal Perineuronal Nets in the Healthy and Injured Spinal Cord

Abstract: Rather than being a stable scaffold, perineuronal nets (PNNs) are a dynamic and specialized extracellular matrix involved in plasticity modulation. They have been extensively studied in the brain and associated with neuroprotection, ionic buffering, and neural maturation. However, their biological function in the spinal cord and the effects of disrupting spinal PNNs remain elusive. The goal of this review is to summarize the current knowledge of spinal PNNs and their potential in pathological conditions such a… Show more

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Cited by 9 publications
(6 citation statements)
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“…In normal physiological conditions, CSPGs are involved in regulating plasticity and preventing maladaptive growth in the adult nervous system [55,56]. They are composed of a core glycoprotein along with glycosaminoglycan (GAG) sugar chains that are covalently attached [57].…”
Section: Inhibitory Moleculesmentioning
confidence: 99%
“…In normal physiological conditions, CSPGs are involved in regulating plasticity and preventing maladaptive growth in the adult nervous system [55,56]. They are composed of a core glycoprotein along with glycosaminoglycan (GAG) sugar chains that are covalently attached [57].…”
Section: Inhibitory Moleculesmentioning
confidence: 99%
“…Physiologically, the spinal cord is surrounded by a plasticity-regulated dynamic extracellular matrix, composed of hyaluronic acid, connexin, and chondroitin sulfate proteoglycan (CSPG) called the perineural network (PNN). 30 In addition, the blood-spinal cord barrier (BSCB) is a physical barrier between the blood and spinal cord parenchyma that prevents toxins, blood cells, and pathogens from entering the spinal cord. 31 The BSCB is composed of endothelial cells, cell-to-cell junctions, basement membranes, and astrocyte foot processes and helps to maintain ion homeostasis in neural signaling.…”
Section: Spinal Cord Injury (Sci)mentioning
confidence: 99%
“…Perineuronal net (PNN) is the main factors limiting the experience‐dependent remodeling of neuronal circuits 6 and is a crucial extra‐neural environment in the central nervous system. PNN is a dense reticular structure mainly composed of a hyaluronic acid skeleton rich in chondroitin sulfate proteoglycans, which is widely found around neurons in the central nervous system, especially PV‐IN 7 .…”
Section: Introductionmentioning
confidence: 99%
“…Physiologically, PNN is involved in maintaining and protecting the activities of neurons, connecting neurons and glial cells, and transmitting signals between them 9 . Researchers have recently focused on PNN's role in cortical plasticity, neural activity regulation, neural circuits functional reconstruction, and neurodegenerative diseases 6,10–12 . A number of studies have shown that chondroitin sulfate ABC (ChABC), a drug targeting core protein saccharides of PNNs, effectively treats SCI 13–15 .…”
Section: Introductionmentioning
confidence: 99%
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