The Role of 25-Hydroxyvitamin D and Other Physiological and Hormonal Factors in Predicting Pregnancy Outcomes in Women Undergoing In Vitro Fertilization and Intracytoplasmic Sperm Injection Treatments

Abstract

Objective This study aimed to investigate the factors associated with pregnancy outcomes and identify potential predictive parameters in women undergoing in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatments.Methods A total of 213 women of reproductive age who underwent their first cycle of IVF or ICSI were included in the study. Demographic, hormonal, metabolic, and endocrine data were collected. Logistic regression analysis was performed to evaluate the associations between various factors and pregnancy outcomes. Receiver operating characteristic (ROC) curve analysis was conducted to assess the predictive performance of the significant factors.Results The multivariate analysis revealed that body mass index (BMI), follicle-stimulating hormone (FSH), hemoglobin A1c (HbA1c), and 25-hydroxyvitamin D (Vitamin_D) were significantly associated with pregnancy outcomes. ROC curve analysis demonstrated that BMI, FSH, HbA1c, and Vitamin_D levels showed moderate predictive performance for pregnancy outcomes, with area under the curve (AUC) values ranging from 0.574 to 0.648.Conclusions This study suggests that BMI, FSH, HbA1c, and Vitamin_D levels may play crucial roles in predicting pregnancy outcomes in women undergoing IVF and ICSI treatments. Clinicians should consider these factors when counseling and managing patients undergoing assisted reproductive treatments.