The Role of Apolipoprotein E in the Pathological Events Following Subarachnoid Hemorrhage: A Review

Guo, Zongduo; Sun, Xiaochuan; Zhang, Junyi

doi:10.1007/978-3-7091-0356-2_1

Cited by 4 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Knowledge of ApoE genotype also provides valuable information about recovery prognosis after an acute event such as stroke (Martinez-Gonzalez and Sudlow, 2006; Guo et al, 2011), delirium (Adamis et al, 2007), or traumatic brain injury (TBI) (Lichtman et al, 2000; Crawford et al, 2009; Mahley et al, 2009; Ponsford et al, 2011). In all these cases, ApoE4 carriers show a worse long-term outcome than ApoE3 carriers, and even sometimes higher risk of death.…”

Section: Prognosismentioning

confidence: 99%

The potential applications of Apolipoprotein E in personalized medicine

Villeneuve

Brisson

Marchant

et al. 2014

Front. Aging Neurosci.

View full text Add to dashboard Cite

Personalized medicine uses various individual characteristics to guide medical decisions. Apolipoprotein (ApoE), the most studied polymorphism in humans, has been associated with several diseases. The purpose of this review is to elucidate the potential role of ApoE polymorphisms in personalized medicine, with a specific focus on neurodegenerative diseases, by giving an overview of its influence on disease risk assessment, diagnosis, prognosis, and therapy. This review is not a systematic inventory of the literature, but rather a summary and discussion of novel, influential and promising works in the field of ApoE research that could be valuable for personalized medicine. Empirical evidence suggests that ApoE genotype informs pre-symptomatic risk for a wide variety of diseases, is valuable for the diagnosis of type III dysbetalipoproteinemia, increases risk of dementia in neurodegenerative diseases, and is associated with a poor prognosis following acute brain damage. ApoE status appears to influence the efficacy of certain drugs, outcome of clinical trials, and might also give insight into disease prevention. Assessing ApoE genotype might therefore help to guide medical decisions in clinical practice.

show abstract

Section: Prognosismentioning

confidence: 99%

The potential applications of Apolipoprotein E in personalized medicine

Villeneuve

Brisson

Marchant

et al. 2014

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Last, the genotype of APOE could influence lipid metabolism following aneurysm rupture and the resultant patient recovery and outcomes. While certain studies have identified an association between the APOE ε4 allele and poor prognosis post-SAH, others have not found such a correlation [85][86][87][88][89]. This suggests that the influence and recovery following cerebral aneurysm rupture linked to the APOE ε4 allele may be complex and potentially affected by multiple factors.…”

Section: Lipid Metabolism and Asahmentioning

confidence: 99%

Intracranial Aneurysms and Lipid Metabolism Disorders: From Molecular Mechanisms to Clinical Implications

Pan,

Shi,

et al. 2023

Biomolecules

View full text Add to dashboard Cite

Many vascular diseases are linked to lipid metabolism disorders, which cause lipid accumulation and peroxidation in the vascular wall. These processes lead to degenerative changes in the vessel, such as phenotypic transformation of smooth muscle cells and dysfunction and apoptosis of endothelial cells. In intracranial aneurysms, the coexistence of lipid plaques is often observed, indicating localized lipid metabolism disorders. These disorders may impair the function of the vascular wall or result from it. We summarize the literature on the relationship between lipid metabolism disorders and intracranial aneurysms below.

show abstract

“…It is worth noting that while bleed size and severity may be controlled, the subtypes of Hp were not in a recent review, emphasizing the need for more studies (82). In addition, CD91 is responsible for ApoE uptake, and reduced ApoE levels were associated with more severe neurological injury and worse outcomes after SAH (83)(84)(85)(86). Thus, Hp-HPX replenishment could scavenge Hb and heme while limiting undesired ApoE uptake (82).…”

Section: Hemopexin's Role In Subarachnoid Hemorrhagementioning

confidence: 99%

Double-edged functions of hemopexin in hematological related diseases: from basic mechanisms to clinical application

Li,

Chen,

Wang

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

It is now understood that hemolysis and the subsequent release of heme into circulation play a critical role in driving the progression of various diseases. Hemopexin (HPX), a heme-binding protein with the highest affinity for heme in plasma, serves as an effective antagonist against heme toxicity resulting from severe acute or chronic hemolysis. In the present study, changes in HPX concentration were characterized at different stages of hemolytic diseases, underscoring its potential as a biomarker for assessing disease progression and prognosis. In many heme overload-driven conditions, such as sickle cell disease, transfusion-induced hemolysis, and sepsis, endogenous HPX levels are often insufficient to provide protection. Consequently, there is growing interest in developing HPX therapeutics to mitigate toxic heme exposure. Strategies include HPX supplementation when endogenous levels are depleted and enhancing HPX’s functionality through modifications, offering a potent defense against heme toxicity. It is worth noting that HPX may also exert deleterious effects under certain circumstances. This review aims to provide a comprehensive overview of HPX’s roles in the progression and prognosis of hematological diseases. It highlights HPX-based clinical therapies for different hematological disorders, discusses advancements in HPX production and modification technologies, and offers a theoretical basis for the clinical application of HPX.

show abstract

The Role of Apolipoprotein E in the Pathological Events Following Subarachnoid Hemorrhage: A Review

Cited by 4 publications

References 23 publications

The potential applications of Apolipoprotein E in personalized medicine

The potential applications of Apolipoprotein E in personalized medicine

Intracranial Aneurysms and Lipid Metabolism Disorders: From Molecular Mechanisms to Clinical Implications

Double-edged functions of hemopexin in hematological related diseases: from basic mechanisms to clinical application

Contact Info

Product

Resources

About