The role of apparent diffusion coefficient as a predictive factor for tumor recurrence in patients with cerebellopontine angle epidermoid tumor

Oh, Hyeong-Cheol; Hong, Chang-Ki; Yoo, Jihwan; Lee, Kyu‐Sung; Jin, Yoon; Ahn, Sung Jun; Suh, Sang Hyun; Park, Hun Ho

doi:10.1007/s10143-021-01654-7

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…This study showed that the ADC was valuable in predicting the absence of recurrence or metastasis in the young breast cancer patients, with an AUC of 0.784 (95% CI: 0.630-0.937, P=0.007). Studies on patients with other malignancies have also shown that the ADC was associated with recurrence or metastasis (17)(18)(19). It can be seen from the above that the ADC of young breast cancer patients was reduced, which indicated that the tumor cell density of young breast cancer patients was high, and it was related to the poor prognosis of young breast cancer patients.…”

Section: Discussionmentioning

confidence: 89%

The comparison between young and old patients and the prognostic roles of magnetic resonance imaging-related parameter characteristics in young patients—a retrospective cohort study

Hu¹,

Jiang²,

Wang³

2023

Gland Surg

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Background: Breast dynamic enhanced magnetic resonance imaging (MRI) is an important in the diagnosis and treatment of breast cancer. However, it is unclear whether the characteristics of breast dynamic enhancement MRI-related parameters in young breast cancer patients are specific. The present study was to study the dynamic enhancement of MRI-related parameter characteristics and its correlation with clinical features in young breast cancer patients.Methods: A total of 196 breast cancer patients admitted to the People's Hospital of Zhaoyuan City from January 2017 to December 2017 were retrospectively collected, and the patients were divided into a young breast cancer group (n=56) and a control group (n=140) according to whether the patient age limit of <40 years old. All patients underwent breast dynamic enhanced MRI and were followed up for 5 years to observe whether there was recurrence or metastasis. We compared the differences of breast dynamic enhanced MRI-related parameters between the 2 groups, and then analyzed the correlation between breast dynamic enhancement MRI-related parameters and clinical features in young breast cancer patients.Results: Compared with the control group, the apparent diffusion coefficient (ADC) of the young breast cancer group was significantly reduced (0.84±0.13 vs. 0.93±0.14 ×10 −3 mm 2 /s, P<0.001); the proportion of patients with non-mass enhancement was significantly increased in the young breast cancer group (25.00% vs. 8.57%, P=0.002). The ADC was significantly positively correlated with age (r=0.226, P=0.001) and negatively correlated with the maximum diameter of the tumor (r=−0.199, P=0.005). The ADC was shown to be valuable in predicting the absence of lymph node metastasis in the young breast cancer patients, and the area under the curve (AUC) was 0.817 [95% confidence interval (CI): 0.702-0.932, P<0.001]. The ADC was shown to be valuable in predicting the absence of recurrence or metastasis in the young breast cancer patients, and the AUC was 0.784 (95% CI: 0.630-0.937, P=0.007). The rates of lymph node metastasis and recurrence at 5 years were significantly increased in young breast cancer patients with non-mass enhancement (P<0.05). Conclusions:The present study provides a reference for further evaluation of the characteristics of young breast cancer patients.

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Section: Discussionmentioning

confidence: 89%

The comparison between young and old patients and the prognostic roles of magnetic resonance imaging-related parameter characteristics in young patients—a retrospective cohort study

Hu¹,

Jiang²,

Wang³

2023

Gland Surg

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“…Due to the high cell density in solid malignant tumor tissue, the ADC in malignant tumor tissue is often in a reduced state. At present, the ADC is used to predict the prognosis of patients with malignant tumor ( 19 - 21 ), and has also been reported in patients with CRC ( 18 ). In the field of neoadjuvant chemotherapy, studies have also confirmed that the ADC is significantly related to the efficacy of neoadjuvant chemotherapy in patients with breast cancer and osteosarcoma ( 16 , 22 , 23 ).…”

Section: Discussionmentioning

confidence: 99%

Predictive value of apparent diffusion coefficient for neoadjuvant chemotherapy in locally advanced colorectal cancer patients

Liu¹,

Zhu²,

Liu³

et al. 2023

J Gastrointest Oncol

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Background: The efficacy of neoadjuvant chemotherapy is closely related to the long-term prognosis of colorectal cancer (CRC) patients. Apparent diffusion coefficient (ADC) is an index in dynamic enhanced magnetic resonance imaging (MRI), reflecting the density of tumor cells. ADC has been shown to be related to the efficacy of neoadjuvant chemotherapy in other malignant tumors, but there is still a lack of relevant research in CRC patients.Methods: A total of 128 patients with CRC treated with neoadjuvant chemotherapy in The First Affiliated Hospital of Xiamen University from January 2016 to January 2017 were retrospectively collected. According to the response after neoadjuvant chemotherapy, the patients were divided into an objective response group (n=80) and a control group (n=48). The clinical characteristics and ADC levels of the two groups were compared, and the predictive value of ADC on the efficacy of neoadjuvant chemotherapy was analyzed. The patients were followed up for 5 years to observe the difference of survival rate between the two groups, and further analyzed the correlation between ADC and survival rate.Results: Compared with the control group, the tumor size in the objective response group was significantly reduced (3.32±1.60 vs. 5.07±2.19 cm, P=0.000); ADC significantly increased (1.23±0.18 vs. 0.98±0.18 ×10 −3 mm 2 /s, P=0.000); albumin significantly increased (39.32±4.14 vs. 37.46±4.18 g/L, P=0.016); the proportion of patients with poorly differentiated or undifferentiated tumor cells was significantly lower (51.25% vs. 72.92%, P=0.016); and the 5-year mortality decreased significantly (40.00% vs. 58.33%, P=0.044). ADC had the highest predictive value of objective response for locally advanced CRC patients after neoadjuvant chemotherapy, and the area under the curve (AUC) was 0.834 [95% confidence interval (CI): 0.765-0.903, P=0.000]; ADC had certain predictive value for the 5-year survival of locally advanced CRC patients, and the AUC was 0.778 (95% CI: 0.696-0.861, P=0.000). ADC >1.055×10 −3 mm 2 /s, tumor size <4.1 cm, and moderately or well differentiated tumors were favorable factors for patients with locally advanced CRC to obtain objective response after neoadjuvant chemotherapy (P<0.05).Conclusions: ADC could be used as a predictor of the efficacy of neoadjuvant chemotherapy in locally advanced CRC patients.

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Predictors of Prolonged Mechanical Ventilation Among Patients with Aneurysmal Subarachnoid Hemorrhage After Microsurgical Clipping

Huang

et al. 2022

Neurol Ther

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Introduction: Aneurysmal subarachnoid hemorrhage (aSAH) is a fatal event with high mortality and morbidity rates. Survivors may require prolonged intubation with mechanical ventilation (MV). However, the risk factors for prolonged intubation in these patients remain unclear. The aim of this study was to determine the predictors of prolonged MV in aSAH patients who underwent surgical clipping. Methods: In total, 108 adult patients with a primary diagnosis of aSAH who were on MV [ 48 h and survived [ 14 days after surgery were included. Clinicodemographic and radiological characteristics, laboratory tests on admission, and initial Glasgow Coma Scale (GCS) and its components were analyzed. Results: The average age of the patients included in the analysis was 59.1 ± 12.5 years. Overall, 32 patients (29.6%) had prolonged MV. The group with prolonged MV showed a higher prevalence of diabetes mellitus and hypertension, lower initial GCS and its components, higher World Federation of Neurosurgeons (WFNS) and Hunt and Hess grades, and higher initial white cell counts. The independent factors associated with prolonged MV were a history of diabetes mellitus (odds ratio [OR] 5.799, 95% confidence interval [CI] 1.109-30.334; P = 0.037) and Hunt and Hess grade 3-5 (OR 7.217, 95% CI 1.090-47.770; P = 0.040). Conclusion: A history of diabetes mellitus and Hunt and Hess grade 3-5 independently predict prolonged MV after microsurgical clipping in patients with aSAH. Thus, knowledge of potential predictors for prolonged MV is essential to improve the early initiation of adequate treatment in the early stages of treatment and provide useful information for communication between caregivers and families.

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The role of apparent diffusion coefficient as a predictive factor for tumor recurrence in patients with cerebellopontine angle epidermoid tumor

Cited by 4 publications

References 30 publications

The comparison between young and old patients and the prognostic roles of magnetic resonance imaging-related parameter characteristics in young patients—a retrospective cohort study

The comparison between young and old patients and the prognostic roles of magnetic resonance imaging-related parameter characteristics in young patients—a retrospective cohort study

Predictive value of apparent diffusion coefficient for neoadjuvant chemotherapy in locally advanced colorectal cancer patients

Predictors of Prolonged Mechanical Ventilation Among Patients with Aneurysmal Subarachnoid Hemorrhage After Microsurgical Clipping

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