The role of artificial intelligence based systems for cost optimization in colorectal cancer prevention programs

Abstract

Colorectal Cancer (CRC) has seen a dramatic increase in incidence globally. In 2019, colorectal cancer accounted for 1.15 million deaths and 24.28 million disability-adjusted life-years (DALYs) worldwide. In India, the annual incidence rates (AARs) for colon cancer was 4.4 per 100,000. There has been a steady rise in the prevalence of CRC in India which may be attributed to urbanization, mass migration of population, westernization of diet and lifestyle practices and a rise of obesity and metabolic risk factors that place the population at a higher risk of CRC. Moreoever, CRC in India differs from that described in the Western countries, with a higher proportion of young patients and more patients presenting with an advanced stage. This may be due to poor access to specialized healthcare and socio-economic factors. Early identification of adenomatous colonic polyps, which are well-recognized pre-cancerous lesions, at the time of screening colonoscopy has been shown to be the most effective measure used for CRC prevention. However, colonic polyps are frequently missed during colonoscopy and moreover, these screening programs necessitate man-power, time and resources for processing resected polyps, that may hamper penetration and efficacy in mid- to low-income countries. In the last decade, there has been significant progress made in the automatic detection of colonic polyps by multiple AI-based systems. With the advent of better AI methodology, the focus has shifted from mere detection to accurate discrimination and diagnosis of colonic polyps. These systems, once validated, could usher in a new era in Colorectal Cancer (CRC) prevention programs which would center around “Leave in-situ” and “Resect and discard” strategies. These new strategies hinge around the specificity and accuracy of AI based systems in correctly identifying the pathological diagnosis of the polyps, thereby providing the endoscopist with real-time information in order to make a clinical decision of either leaving the lesion in-situ (mucosal polyps) or resecting and discarding the polyp (hyperplastic polyps). The major advantage of employing these strategies would be in cost optimization of CRC prevention programs while ensuring good clinical outcomes. The adoption of these AI-based systems in the national cancer prevention program of India in accordance with the mandate to increase technology integration could prove to be cost-effective and enable implementation of CRC prevention programs at the population level. This level of penetration could potentially reduce the incidence of CRC and improve patient survival by enabling early diagnosis and treatment. In this review, we will highlight key advancements made in the field of AI in the identification of polyps during colonoscopy and explore the role of AI based systems in cost optimization during the universal implementation of CRC prevention programs in the context of mid-income countries like India.

Towards Ideal Health Ecosystem With Artificial Intelligence-Driven Medical Services in India: An Overview

“…Research in this area has been continually expanding, and in various studies, the cost-effectiveness of digital healthcare for type 2 diabetes and hypertension [21], mental health [22], as well as telemedicine for distant orthopedic consultations [23], atrial fibrillation [24], hospital-acquired pressure injuries [25], colorectal cancer [26], Food safety risk management [27] was thoroughly examined. The healthcare provider, insurance, pharmaceutical, and medical technology industries stand to benefit the most from it [28].…”

Assessing the contribution of nine preventable risk factors attributed to the burden of early onset colorectal cancer in Gulf Cooperation Council (GCC) countries

“…In 2019, the worldwide burden of colorectal cancer imposed a significant health threat, contributing to over 24.28 million disability-adjusted life-years (DALYs) and 1.15 million fatalities. ( Rao et al, 2022 Sep ) It emerged as the second leading cause of cancer-related deaths globally. ( Siegel et al, 2022 ) Alarming trends in the incidence and prevalence of early onset colorectal cancer (EO-CRC) have been noted, with the highest increases in regions with a high-middle Socio-demographic Index (SDI), including the Gulf Cooperation Council (GCC) nations.…”