The role of caspase-dependent and caspase-independent pathways of apoptosis in the premature rupture of the membranes: A case-control study

Negara, Ketut Surya; Suwiyoga, Ketut; Sudewi, Raka; Astawa, Nyoman Mantik; Arijana, Gusti Nyoman Kamasan; Tunas, Ketut; Pemayun, Tjokorda Gede Astawa

doi:10.18502/ijrm.v13i6.7285

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Zhang et al ( 19 ) notes that Keap-1/Nrf2 signaling pathway activation following oxidative stress is associated with patients with PPROM (preterm premature rupture of membrane). A related study ( 20 ) shows that high Caspase-3, AIF, and low Bcl-2 expression are risk factors for PROM. Infants in the PROM group experienced higher rates of infection, asphyxia, and jaundice.…”

Section: Discussionmentioning

confidence: 99%

Development of a Novel Nomogram for Predicting Premature Rupture of Membrane in Pregnant Women With Vulvovaginal Candidiasis

Liu

Wang

et al. 2021

Front. Med.

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Objective: The aim of this study was to develop a nomogram to predict the risk of premature rupture of membrane (PROM) in pregnant women with vulvovaginal candidiasis (VVC).Patients and methods: We developed a prediction model based on a training dataset of 417 gravidas with VVC, the data were collected from January 2013 to December 2020. The least absolute shrinkage and selection operator regression model was used to optimize feature selection for the model. Multivariable logistic regression analysis was applied to build a prediction model incorporating the feature selected in the least absolute shrinkage and selection operator regression model. Discrimination, calibration, and clinical usefulness of the prediction model were assessed using the C-index, calibration plot, and decision curve analysis. Internal validation was assessed using bootstrapping validation.Results: Predictors contained in the prediction nomogram included age, regular perinatal visits, history of VVC before pregnancy, symptoms with VVC, cured of VVC during pregnancy, and bacterial vaginitis. The model displayed discrimination with a C-index of 0.684 (95% confidence interval: 0.631–0.737). Decision curve analysis showed that the PROM nomogram was clinically useful when intervention was decided at a PROM possibility threshold of 13%.Conclusion: This novel PROM nomogram incorporating age, regular perinatal visits, history of VVC before pregnancy, symptoms with VVC, cured of VVC during pregnancy, and bacterial vaginitis could be conveniently used to facilitate PROM risk prediction in gravidas.

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Section: Discussionmentioning

confidence: 99%

Development of a Novel Nomogram for Predicting Premature Rupture of Membrane in Pregnant Women With Vulvovaginal Candidiasis

Liu

Wang

et al. 2021

Front. Med.

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“…The apoptosis pathway may also prove difficult to predict, as cancer cells notoriously are able to change biochemical pathway compositions and upregulate new inhibitors. As it is proven that apoptosis can occur independent of caspase function (Negara et al, 2020), the pathway may be altered so that caspase activation is not induced. It may also occur that caspases are mutated beyond functionality, losing their ability to initiate the cascade of apoptotic activities, and thus making XIAP removal from the cytosol useless.…”

Section: Caveats Of Proposalmentioning

confidence: 99%

Chemical Inductors of Proximity Associating DNA Damage-Binding Protein 2 and XIAP as Targeted Therapy for General Cancers

Shen

2023

JIMR

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While all cancers are classified as uncontrolled proliferations of cells, they manifest in many forms and may arise from a wide range of cellular anomalies. It has thus made finding a universal targeted cancer therapy a highly desirable goal. Several common biochemical changes associated with oncogenesis have been described in literature across all cancers, namely the Warburg effect (Heiden et al., 2009) (Warburg, 1925) and resistance to apoptosis (Hanahan & Weinburg, 2011). These hallmarks possess high potential to be used as targeting mechanisms in cancer treatment. Recent findings by Gourlsankar et al. have shown a promising new technique of linking the activity of a frequently activated cancer driver (B cell lymphoma 6) with an apoptosis promotor, allowing the creation of a synthetic biochemical pathway which rewires cancer driver activity to induce cell death, done through using a drug to covalently link two molecules that bond to each protein (Gourlsankar et al., 2023). While this approach specifically targeted diffuse large B cell lymphoma, it shows high promise for new strategies to approach eliminating cancer cells, namely in the artificial activation of tumor suppressor function through protein linkage and the consequent association in protein location within the cytosol. This paper aims to review the strategy of Gourlsankar et al., identifying ways to expand its concept towards generalized treatments using the hallmarks of cancer, and proposing a new theoretical drug mechanism using the linkage of DNA damage-binding protein 2 (DDB2) with X-linked inhibitor of apoptosis (XIAP) to induce cell death.

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Premature rupture of membranes in preterm pregnancy: pathogenetic mechanisms and prognosis

Talanova¹,

Малышкина²,

Borzova³

et al. 2022

Probl. reprod.

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The role of caspase-dependent and caspase-independent pathways of apoptosis in the premature rupture of the membranes: A case-control study

Cited by 3 publications

References 21 publications

Development of a Novel Nomogram for Predicting Premature Rupture of Membrane in Pregnant Women With Vulvovaginal Candidiasis

Development of a Novel Nomogram for Predicting Premature Rupture of Membrane in Pregnant Women With Vulvovaginal Candidiasis

Chemical Inductors of Proximity Associating DNA Damage-Binding Protein 2 and XIAP as Targeted Therapy for General Cancers

Premature rupture of membranes in preterm pregnancy: pathogenetic mechanisms and prognosis

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