The role of complement activation in the pathogenesis of Fuchs’ dystrophy

Füst, Ágnes; Csuka, Dorottya; Imre, László; Bausz, Mária; Nagymihály, Attila; Füst, G.; Csorvási, Ágnes; Németh, János; Varga, Lilian

doi:10.1016/j.molimm.2013.11.019

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Yamaguchi et al [86] found a notable up-regulation of the complement activation pathway in corneal transplantation Füst et al [87] reported that the complement system might be activated both through the classical and alternative pathways in the aqueous humor of the patients with Fuchs' dystrophy. In addition to this, certain scholars have found that the presence of an increased concentration of C1rs-C1inh complex in tear samples [88], suggests the classical pathway of complement might be activated in the early postoperative period after penetrating keratoplasty.…”

Section: Discussionmentioning

confidence: 99%

Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis

Zhu

Inomata

Zazzo

et al. 2021

JCM

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Corneal transplantation is one of the most successful forms of solid organ transplantation; however, immune rejection is still a major cause of corneal graft failure. Both innate and adaptive immunity play a significant role in allograft tolerance. Therefore, immune cells, cytokines, and signal-transduction pathways are critical therapeutic targets. In this analysis, we aimed to review the current literature on various immunotherapeutic approaches for corneal-allograft rejection using the PubMed, EMBASE, Web of Science, Cochrane, and China National Knowledge Infrastructure. Retrievable data for meta-analysis were screened and assessed. The review, which evaluated multiple immunotherapeutic approaches to prevent corneal allograft rejection, showed extensive involvement of innate and adaptive immunity components. Understanding the contribution of this immune diversity to the ocular surface is critical for ensuring corneal allograft survival.

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Section: Discussionmentioning

confidence: 99%

Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis

Zhu

Inomata

Zazzo

et al. 2021

JCM

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“…As CE acts as a barrier to entry of aqueous humour in the cornea that is compromised in FECD, downregulation of APOE may contribute to its breakdown. Interestingly, complement activation has been reported to occur in FECD . Downregulation of APOE likely also compromises protection of CECs from reactive immuno‐modulatory molecules and oxidants leading to cell injury and loss in FECD.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, complement activation has been reported to occur in FECD. 50 Downregulation of APOE likely also compromises protection of CECs from reactive immuno-modulatory molecules and oxidants leading to cell injury and loss in FECD. Further research is required to understand the role/s of dysregulation of APOE in the disease.…”

Section: Discussionmentioning

confidence: 99%

Reduced expression of apolipoprotein E and immunoglobulin heavy constant gamma 1 proteins in Fuchs endothelial corneal dystrophy

Kuot

Ronci

Mills

et al. 2019

Clinical Exper Ophthalmology

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Background Fuchs endothelial corneal dystrophy (FECD) is a progressive and potentially a sight threatening disease, and a common indication for corneal grafting in the elderly. Aberrant thickening of Descemet's membrane, formation of microscopic excrescences (guttae) and gradual loss of corneal endothelial cells are the hallmarks of the disease. The aim of this study was to identify differentially abundant proteins between FECD‐affected and unaffected Descemet's membrane. Methods Label‐free quantitative proteomics using nanoscale ultra‐performance liquid chromatography‐mass spectrometry (nUPLC‐MSE) was employed on affected and unaffected Descemet's membrane extracts, and interesting findings were further investigated using quantitative reverse transcription‐polymerase chain reaction and immunohistochemical techniques. Results Quantitative proteomics revealed significantly lower abundance of apolipoprotein E (APOE) and immunoglobulin heavy constant gamma 1 protein (IGHG1) in affected Descemet's membrane. The difference in the distribution of APOE between affected and unaffected Descemet's membrane and of IGHG1 detected by immunohistochemistry support their down‐regulation in the disease. Comparative gene expression analysis showed significantly lower APOE mRNA levels in FECD‐affected than unaffected corneal endothelium. IGHG1 gene is expressed at extremely low levels in the corneal endothelium, precluding relative expression analysis. Conclusions This is the first study to report comparative proteomics of Descemet's membrane tissue, and implicates dysregulation of APOE and IGHG1 proteins in the pathogenesis of Fuchs endothelial corneal dystrophy.

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The presence and distribution of G protein-coupled receptor 35 (GPR35) in the human cornea – Evidences from in silico gene expression analysis and immunodetection

Matysik-Woźniak

Wnorowski

Turski

et al. 2019

Experimental Eye Research

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The role of complement activation in the pathogenesis of Fuchs’ dystrophy

Cited by 4 publications

References 15 publications

Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis

Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis

Reduced expression of apolipoprotein E and immunoglobulin heavy constant gamma 1 proteins in Fuchs endothelial corneal dystrophy

The presence and distribution of G protein-coupled receptor 35 (GPR35) in the human cornea – Evidences from in silico gene expression analysis and immunodetection

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