The role of complement regulatory proteins in peripheral blood cells of patients with systemic lupus erythematosus: Review

Alegretti, Ana Paula; Schneider, Laiana; Piccoli, Amanda Kirchner; Xavier, Ricardo Machado

doi:10.1016/j.cellimm.2012.06.008

Cited by 16 publications

(16 citation statements)

References 74 publications

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“…Part of the role of complement relates to recognizing and clearing damaged cells; given the organ damage occurring in TTP secondary to microvascular thrombosis, this alone may be sufficient to activate the alternative complement pathway. Over‐activation of the alternative pathway has also been found to be implicated in a variety of autoimmune diseases (Klos et al , ), including systemic lupus erythematosus (Alegretti et al , ; Elkon & Santer, ). Indeed it is the alternative pathway that has been found to be overactive as a result of defective complement regulation in aHUS(Kavanagh & Goodship, ,b, ).…”

Section: Discussionmentioning

confidence: 99%

Complement and cytokine response in acute Thrombotic Thrombocytopenic Purpura

et al. 2013

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Complement dysregulation is key in the pathogenesis of atypical Haemolytic Uraemic Syndrome (aHUS), but no clear role for complement has been identified in Thrombotic Thrombocytopenic Purpura (TTP). We aimed to assess complement activation and cytokine response in acute antibody-mediated TTP. Complement C3a and C5a and cytokines (interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor, interferon-γ and IL-17a) were measured in 20 acute TTP patients and 49 remission cases. Anti-ADAMTS13 immunoglobulin G (IgG) subtypes were measured in acute patients in order to study the association with complement activation. In acute TTP, median C3a and C5a were significantly elevated compared to remission, C3a 63·9 ng/ml vs. 38·2 ng/ml (P < 0·001) and C5a 16·4 ng/ml vs. 9·29 ng/ml (P < 0·001), respectively. Median IL-6 and IL-10 levels were significantly higher in the acute vs. remission groups, IL-6: 8 pg/ml vs. 2 pg/ml (P = 0·003), IL-10: 6 pg/ml vs. 2 pg/ml (P < 0·001). C3a levels correlated with both anti-ADAMTS13 IgG (rs = 0·604, P = 0·017) and IL-10 (rs = 0·692, P = 0·006). No anti-ADAMTS13 IgG subtype was associated with higher complement activation, but patients with the highest C3a levels had 3 or 4 IgG subtypes present. These results suggest complement anaphylatoxin levels are higher in acute TTP cases than in remission, and the complement response seen acutely may relate to anti-ADAMTS13 IgG antibody and IL-10 levels.

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Section: Discussionmentioning

confidence: 99%

Complement and cytokine response in acute Thrombotic Thrombocytopenic Purpura

et al. 2013

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“…Jk:3, on the urea transporter, protects RBCs during the passage in the capillaries of the kidney . CD55 and CD59 protect RBCs from complement‐mediated lysis and their reduced expression is responsible for hemolysis in paroxysmal nocturnal hemoglobinuria . These considerations predict that reduced expression of CD35, Jk:3, CD55, and CD59 on cRBCs from CB makes them unsuited for both diagnostic and clinical use.…”

Section: Discussionmentioning

confidence: 99%

Mononuclear cells from a rare blood donor, after freezing under good manufacturing practice conditions, generate red blood cells that recapitulate the rare blood phenotype

et al. 2013

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Background Cultured red blood cells (cRBCs) from cord blood (CB) have been proposed as transfusion products. Whether buffy-coats discarded from blood donations (AB) may be used to generate cRBCs for transfusion has not been investigated. Study Design and Methods Erythroid progenitor cell content and numbers and blood group antigen profiles of erythroblasts (ERYs) and cRBCs generated in Human Erythroid Massive Amplification (HEMA) culture by CB (n=7) and AB (n=33, three females, three males, one AB with rare blood antigens cryopreserved using CB protocols) were compared. Results Variability was observed both in progenitor cell content (2-fold) and number of ERYs generated (1-log) by CB and AB in HEMA. The average progenitor cell contents of the subset of AB and CB analyzed were similar. AB generated numbers of ERYs 3-times lower (p<0.01) than CB in HEMA containing fetal bovine serum but similar to CB in HEMA containing human proteins. Female AB contained 2-times less (p<0.05) erythroid progenitor cells but generated numbers of ERYs similar to those generated by male AB. Cryopreserved AB with a rare blood group phenotype and shipped to another laboratory generated great numbers of ERYs, 90% of which matured into cRBCs. Blood group antigen expression was consistent with the donor genotype for ERYs generated both by CB and AB but concordant with that of native RBCs only for cells derived from AB. Conclusion Buffy-coats from regular donors, including a donor with rare phenotypes stored under conditions established for CB, are not inferior to CB for the generation of cRBCs.

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“…CD55, a decay accelerating factor (DAF), accelerates the decay of C3 convertases. Finally, CD59 or protectin inhibits the binding of C9 to the C5b-8 complex, thereby preventing the last step needed for MAC formation [20]. These-membrane bound regulators, CD46, CD55 and CD59, are expressed on all circulating cells, including all the cell types addressed in this review [21].…”

Section: Introductionmentioning

confidence: 99%

Production of complement components by cells of the immune system

Lubbers

Essen

Kooten

et al. 2017

Clinical and Experimental Immunology

380

281

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SummaryThe complement system is an important part of the innate immune defence. It contributes not only to local inflammation, removal and killing of pathogens, but it also assists in shaping of the adaptive immune response. Besides a role in inflammation, complement is also involved in physiological processes such as waste disposal and developmental programmes. The complement system comprises several soluble and membrane-bound proteins. The bulk of the soluble proteins is produced mainly by the liver. While several complement proteins are produced by a wide variety of cell types, other complement proteins are produced by only a few related cell types. As these data suggest that local production by specific cell types may have specific functions, more detailed studies have been employed recently analysing the local and even intracellular role of these complement proteins.Here we review the current knowledge about extrahepatic production and/ or secretion of complement components. More specifically, we address what is known about complement synthesis by cells of the human immune system.

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The role of complement regulatory proteins in peripheral blood cells of patients with systemic lupus erythematosus: Review

Cited by 16 publications

References 74 publications

Complement and cytokine response in acute Thrombotic Thrombocytopenic Purpura

Complement and cytokine response in acute Thrombotic Thrombocytopenic Purpura

Mononuclear cells from a rare blood donor, after freezing under good manufacturing practice conditions, generate red blood cells that recapitulate the rare blood phenotype

Production of complement components by cells of the immune system

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