The Role of Cyclic AMP in Gonadal Steroidogenesis1

The regulation of androgen and estrogen formation in fetal gonads

“…The measurement of gonadotropin binding in fetal gonads and of testosterone and adenosine-3',5'-cyclic monophosphate (cyclic AMP) by radioimmunoassay have also been described Dufau et al, 1973 (Milewich et al, 1977). More recently we have measured the ability of fetal rabbit ovaries and testes to convert [7-3 H] (Marsh, 1975 George et al,1978a). This corresponds closely to the ability of hCG to stimulate cholesterol side-chain cleavage activity (fig.…”

Differential regulation by LH and prostaglandins of steroidogenesis in small and large luteal cells of the ewe

“…It is generally accepted that LH stimulates steroidogenesis via the intracellular second messenger, cAMP (Marsh, 1976). This model appears to hold true for the small luteal cell.…”

Metabolic and morphological changes produced by gonadotrophins and cyclic AMP in the oocyte and cumulus oophorus of preovulatory rat follicles

“…This process comprises changes in the steroidogenesis, resumption of oocyte meiosis, morphological transformation of the cumulus oophorus, luteinization of the granulosa cells and eventually follicular rupture and release of the mature ovum. According to current opinion the changes in steroidogenesis and luteinization are mediated by cyclic AMP (review : Kolena and Channing, 1972 ;Marsh, 1976 (Nilsson, 1974 ;Tsafriri et al, 1976 (Hillensjo, 1976 ;Dekel et al, 1976). These (Dekel and Kraicer, 1974 ;.…”