The Role of Exercise Testing in Interstitial Lung Disease

Harris-Eze, A O; Marciniuk, Darcy

doi:10.1097/00045413-199507000-00003

Cited by 5 publications

(2 citation statements)

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“…This peculiar breathing pattern contributes to the abnormally high ratio between physiological dead space volume (VD) and VT in ILD subjects [31]. In fact, while in healthy individuals the VD/VT ratio decreases as ventilatory requirements increase during exercise, in ILD subjects it is not uncommon for the VD/VT ratio to remain the same, or even increase under similar conditions, reducing the ability of the lungs to clear the increasing carbon dioxide production during exercise without a further increase in V′E [32]. Despite this abnormal ventilatory pattern, respiratory mechanics don't seem to be the unique contributors to exercise limitation in ILD patients.…”

Section: Exercise Respiratory Physiology In Ildmentioning

confidence: 99%

Exertional dyspnoea in interstitial lung diseases: the clinical utility of cardiopulmonary exercise testing

Bonini

Fiorenzano

2017

Eur Respir Rev

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Interstitial lung diseases (ILDs) represent a heterogeneous group of pathologies characterised by alveolar and interstitial damage, pulmonary inflammation (usually associated with fibrosis), decreased lung function and impaired gas exchange, which can be attributed to either a known or an unknown aetiology. Dyspnoea is one of the most common and disabling symptoms in patients with ILD, significantly impacting quality of life. The mechanisms causing dyspnoea are complex and not yet fully understood. However, it is recognised that dyspnoea occurs when there is an imbalance between the central respiratory efferent drive and the response of the respiratory musculature. The respiratory derangement observed in ILD patients at rest is even more evident during exercise. Pathophysiological mechanisms responsible for exertional dyspnoea and reduced exercise tolerance include altered respiratory mechanics, impaired gas exchange, cardiovascular abnormalities and peripheral muscle dysfunction.This review describes the respiratory physiology of ILD, both at rest and during exercise, and aims to provide comprehensive and updated evidence on the clinical utility of the cardiopulmonary exercise test in the assessment and management of these pathological entities. In addition, the role of exercise training and pulmonary rehabilitation programmes in the ILD population is addressed.

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Section: Exercise Respiratory Physiology In Ildmentioning

confidence: 99%

Exertional dyspnoea in interstitial lung diseases: the clinical utility of cardiopulmonary exercise testing

Bonini

Fiorenzano

2017

Eur Respir Rev

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“…In normal subjects, it is usual for the dead space to tidal volume ratio (V D /V T ) to decrease as ventilatory requirements increase during exercise. In ILD subjects, it is not uncommon for the V D /V T to remain the same, or even increase under similar conditions, reducing the ability of the lungs to clear the increasing carbon dioxide production during exercise without a further increase in V E …”

Section: Exercise Physiology In Iipmentioning

confidence: 99%

Exercise pathophysiology and the role of oxygen therapy in idiopathic interstitial pneumonia

et al. 2015

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Exercise limitation is a common feature in idiopathic interstitial pneumonia (IIP). There are multiple contributing pathophysiological mechanisms, including ventilatory mechanical limitation, impaired gas exchange, pulmonary vascular insufficiency and peripheral muscle dysfunction. Progressive exertional dyspnoea and functional incapacity impact significantly on quality of life. Exercise-induced desaturation is frequently observed and is predictive of poorer outcomes. Tests to assess the cardiorespiratory system under stress (e.g. cardiopulmonary exercise testing and the 6-min walk test) can provide important physiologic and prognostic information as adjuncts to resting measurements of lung function. Despite many advances in understanding disease mechanisms, therapies to improve exercise capacity, symptom burden and quality of life are lacking. Exercise training and supplemental oxygen are two potential interventions that require closer evaluation in patients with IIP.

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Clinical Exercise Testing in Chronic Airflow Limitation

Marciniuk

Gallagher

1996

Medical Clinics of North America

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The Role of Exercise Testing in Interstitial Lung Disease

Cited by 5 publications

References 0 publications

Exertional dyspnoea in interstitial lung diseases: the clinical utility of cardiopulmonary exercise testing

Exertional dyspnoea in interstitial lung diseases: the clinical utility of cardiopulmonary exercise testing

Exercise pathophysiology and the role of oxygen therapy in idiopathic interstitial pneumonia

Clinical Exercise Testing in Chronic Airflow Limitation

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