The role of functional polymorphisms of the TNF-α gene promoter in the risk of ischemic stroke in Chinese Han and Uyghur populations: Two case–control studies

Tong, Yeqing; Yang, Geng; Xu, Jing; Wang, Zhihong; Zhang, Yanwei; Lin, Liangqiang; Zhang, Renli; Deng, Pingjian; Li, Yongbin; Hou, Wanli; Chai, Yimin; Mason, Katherine A.; Lu, Zuxun; Cheng, Jinquan

doi:10.1016/j.cca.2010.05.007

Cited by 19 publications

(19 citation statements)

References 37 publications

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“…Other studies contradict the results mentioned above, revealing a connection between TNF polymorphisms and stroke. One of these studies highlights the protective role of TNF in ischemic stroke [26], while another study performed in the USA, places the same polymorphisms in the group of genetic risk factors for stroke [27]. Although there is increased evidence about the role of proinfl amatory cytokines such as TNF and stroke etiopathogenesis, the results of our study failed to demonstrate this hypothesis.…”

Section: Discussioncontrasting

confidence: 74%

Genetic Polymorphism TNFα -308G>A and Ischemic Stroke in Northern Romania

Petrisor¹,

Popp²,

Cătană³

et al. 2013

Acta Medica Marisiensis

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Introduction: Stroke is one of the leading causes of death in Romania. Evidence in supporting the role of the pro-infl ammatory cytokine TNFalpha in ischemic pathogenesis is now well established. The aim of the present study is to evaluate the relationship between TNF -308G>A polymorphism and ischemic stroke in a Northern Romanian population group and to determine whether it has an infl uence on the risk of cerebral events. This is a cross-sectional, randomized, case-control study for the evaluation of TNF -308G>A polymorphism alleles frequency among patients with ischemic stroke. Material and method: The study included 108 patients diagnosed with ischemic stroke (neurological and CT scan examination), and 118 healthy unrelated controls. TNF -308G>A genotyping was carried out using PCR-RFLP technique. The amplifi cation of the relevant gene fragment was subjected to restriction enzyme digestion, followed by gel electrophoresis. Results: Molecular analysis did not reveal an increased frequency of GA mutant genotype in the study group compared to the control group (p = 0.879, OR = 0.928, CI = 0.512-1.682). Conclusions:We found no signifi cant differences in distribution of the TNF -308G>A polymorphism between ischemic stroke patients and controls.

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Section: Discussioncontrasting

confidence: 74%

Genetic Polymorphism TNFα -308G>A and Ischemic Stroke in Northern Romania

Petrisor¹,

Popp²,

Cătană³

et al. 2013

Acta Medica Marisiensis

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“…A study carried out by Banerjee et al (2008) in north India also could not find any association. Tong et al (2010) in China showed the protective role of TNFα in ischemic stroke. However, Hoppe et al (2007) in the USA found an association between TNFα and stroke.…”

Section: Discussionmentioning

confidence: 98%

Tumour necrosis factor alpha and interleukin 10 gene polymorphisms and the risk of ischemic stroke in south Indian population

Sultana

Kolla

Jeedigunta

et al. 2011

J Genet

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“…Such genetic polymorphisms were described for the genes coding for several proinflammatory cytokines (IL-1β, TNF-α, IL-6), being responsible for both the rate of transcription of the corresponding genes and plasma concentration of cytokines [19,23,24]. This could be an explanation for the different patterns of dynamic for the inflammatory markers in our study, during the rehabilitation period.…”

Section: Discussionmentioning

confidence: 52%

Dynamics of Inflammatory Markers in Post-Acute Stroke Patients Undergoing Rehabilitation

et al. 2010

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Stroke is a pathological condition associated with an enhanced inflammatory response that has a multifactorial etiology. We evaluated the dynamic of plasma concentrations of IL-1α, IL-6, IL-8, TNF-α, soluble form of intercellular adhesion molecule 1, and lipoprotein (a) [Lp(a)] during the rehabilitation of post-acute stroke patients (n = 20), in parallel with control subjects (n = 24). Stroke patients had significantly increased concentrations of IL-6, TNF-α, and Lp(a) when compared to healthy controls. It was found that the changes in the IL-6, IL-8, and TNF-α concentrations associated with the pathological condition were statistically significant (χ2 = 4.81, p = 0.028, χ2 = 10.40, p = 0.005 and χ2 = 6.73, p = 0.034, respectively). The decrease of Lp(a) during the rehabilitation had statistical significance (p = 0.043), while the decrease of IL-1α had marginal significance (p = 0.071). IL-1α, TNF-α, and Lp(a) concentrations were significantly negatively correlated with the Barthel index values, suggesting that the decrease of these inflammatory markers was beneficial for patients' recovery.

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The role of functional polymorphisms of the TNF-α gene promoter in the risk of ischemic stroke in Chinese Han and Uyghur populations: Two case–control studies

Cited by 19 publications

References 37 publications

Genetic Polymorphism TNFα -308G>A and Ischemic Stroke in Northern Romania

Genetic Polymorphism TNFα -308G>A and Ischemic Stroke in Northern Romania

Tumour necrosis factor alpha and interleukin 10 gene polymorphisms and the risk of ischemic stroke in south Indian population

Dynamics of Inflammatory Markers in Post-Acute Stroke Patients Undergoing Rehabilitation

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