The Role of Human Coagulation Factors in Serum-Induced Thrombosis *

Activation Product, Factor IX, Serum Thrombotic Accelerator Activity, and Serum-induced Thrombosis*

“…The activity in glass-contacted human serum initiating these thrombi has been termed serum thrombotic accelerator (STA) activity (2). It can be measured by a rabbit assay (3) and is distinct from tissue thromboplastin, platelets, and thrombin (4,5).…”

“…It can be measured by a rabbit assay (3) and is distinct from tissue thromboplastin, platelets, and thrombin (4,5). Silicone-processed ("intact") serum from normal subjects and glasscontacted serum from patients deficient in coagulation Factors XII (Hageman), XI (PTA), or IX (PTC) develop little, if any, STA activity (2,5). In contrast, glass-contacted serum from patients with other clotting defects develops normal STA activity (2).…”

The Effect of Lanthanides and Actinides on Blood Coagulation. I. Evidence for and Properties of a New Serum Thromboplastic Factor*

“…Since thorium-treated serum retains the STA activity of Wessler and Reimer (41), TVF must also be distinct from this moiety. This consideration similarly applies to activation product of Henderson and Rapaport (42).…”

Thromboplastin Generation Accelerator, a Newly Recognized Component of the Blood Coagulation Mechanism Present in Excess in Certain Thrombotic States*

“…Recent years have witnessed an increasing interest in the study of the possible relationship of blood coagulation to intravascular thrombosis (1)(2)(3)(4). In spite of numerous methods of investigation, a consistent means of demonstrating and defining a clotting abnormality in thromboembolic diseases has not emerged.…”

“…Since we have demonstrated excess TGA activity as well with soybean phosphatide as with platelets (5), the convenience of the former has led to its routine use. 4. Electrophoresis of plasmatic factors (14).…”