The Role of Human Metapneumovirus in Pediatric Respiratory Tract Infection in Qatar

Althani, Asma; Azzam, Samir B; Abboubaker, Hafsa M Al-Sheik; Abdel-Hadi, Fatma G; Elsheikh, Mamoun; Janahi, Ibrahim

doi:10.2217/fvl.10.13

Cited by 8 publications

(7 citation statements)

References 34 publications

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“…Our study revealed that RSV and RV were the most commonly detected causative agents. This finding is in contrast to a previous report with a small sample size of 56 children with respiratory tract infection (RTI) in Qatar in which hMPV was the most frequently isolated virus [ 10 ]. Our findings are, however, in line with a number of large studies conducted in the Middle East and elsewhere [ 11 – 14 ].…”

Section: Discussioncontrasting

confidence: 97%

Viral aetiology of bronchiolitis in hospitalised children in Qatar

et al. 2017

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BackgroundBronchiolitis is considered one of the earliest and most common causes of hospitalisation in young children. Development of molecular technologies allowed a better understanding of bronchiolitis aetiology. Results from cohort studies evaluating the association between single, multiple viral infections and clinical outcomes are conflicting. Data on viral bronchiolitis in children were found to be limited in Qatar. This study aimed to determine frequency and seasonal trends of viral pathogens causing acute bronchiolitis, and to explore association between viral pathogens, disease severity and length of stay (LOS).MethodsThis is a retrospective descriptive study, including children admitted in 2010 and 2011 with acute bronchiolitis. Presenting history, physical examination and respiratory viral co-infections as detected by molecular assays were analysed.ResultsAt least one virus was detected in 315/369 (85.4%) of included children with single and multiple viruses in 67 and 33% of cases respectively. Respiratory syncytial virus (RSV) was the most detected virus, accounting for 51.2% followed by rhinovirus (RV) in 25.5% of cases. Fall and summer admissions were associated with longer LOS. On multivariate logistic regression analysis, retraction (OR 3.96; 95% CI 1.64,9.59) and age group 1–3 months (OR 3.09; 95% CI 1.06,9.05) were associated with longer LOS. Crepitation (OR 9.15; 95% CI 1.58,53.13), retraction (OR 4.10; 95% CI 1.05,16.12) and respiratory rate (OR 1.46; 95% CI 1.28,1.66) were associated with moderate to severe bronchiolitis. Identifying the viral agent did not influence disease severity or LOS.ConclusionClinical presentation is of more relevance to LOS and disease severity than the detected viruses. Future studies should investigate the interplay between climate characteristics, population’s factors and the most detectable circulating viruses.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-017-2225-z) contains supplementary material, which is available to authorized users.

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Section: Discussioncontrasting

confidence: 97%

Viral aetiology of bronchiolitis in hospitalised children in Qatar

et al. 2017

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“…Most of the hMPV‐positive patients were of age 2 years and less (76%), and of age 59 years and above (24%), and these results parallel most if not all studies that have shown that hMPV is a common disease in children and can cause severe infections in the elderly [Falsey et al, 2003; Wolf et al, 2003; Principi et al, 2006; Hermos et al, 2010]. In Qatar the hMPV virus was the most commonly detected virus, accounting for 74% of all respiratory infections among pediatric patients aged 1 month to 5 years, and this result is very similar to the current study finding that most of hMPV‐positive patients were of age 2 years and less than 76% [Al‐Thani et al, 2010]. Our results highlight the importance to introduce a screening test for hMPV infection in routine diagnosis, and to have appropriate medical management for hMPV‐positive cases as other studies have recommended previously [Deffrasnes et al, 2007].…”

Section: Disscussionsupporting

confidence: 86%

Human metapneumovirus in patients with respiratory tract infection in Kuwait

Al-Turab

Chehadeh

Al-Mulla

et al. 2011

Journal of Medical Virology

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Human metapneumovirus (hMPV) has been recognized as an important cause of respiratory tract infections in all age groups and in all geographical area. The role of hMPV in causing respiratory tract infections in Kuwait was not yet investigated. The aim of this study was to determine the prevalence of hMPV infection in Kuwait among patients with respiratory tract infection with respect to other respiratory viruses. During January-December 2009, 460 respiratory samples from 388 patients with respiratory tract infection were collected from different hospitals. They were tested for hMPV RNA by real-time PCR, and for other respiratory viruses by conventional PCR. Out of 388 patients, 110 (28%) were positive for viral respiratory infections; 21 (5.4%) were positive for hMPV, 29 (7.5%) were positive for rhinovirus, 13 (4%) were positive for respiratory syncytial virus, and 10 (3%) were positive for adenovirus. Most (n = 19, 90.5%) of hMPV-positive patients were admitted to the intensive care unit, 76% of them were of age 2 years and below, and 24% of age 59 years and above. All hMPV-positive elderly patients had pneumonia while 50% of hMPV-positive infants had bronchopneumonia. Children with hMPV/rhinovirus co-infection (n = 3, 1%) had recurrent chest infection and frequent intensive care unit admission. The hMPV infection was mostly detected between December and May, and genotype B was more prevalent than genotype A. This is the first study demonstrating the prevalence of hMPV infection in Kuwait, and suggests that hMPV infection is prevalent in infants and elderly patients with lower respiratory tract infection.

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“…Rhinovirus infection was the most common etiology of ARI consistent with other studies from Lebanon and other countries 18,20,21. In neighboring Jordan and Egypt rhinovirus incidence was second to RSV, but the population captured in these studies was younger than that included in our study 22,23. The overall viral ARI incidence (52.5%) in our study lower than that recently reported by Finianos et al (70%) in Lebanon 18.…”

Section: Discussionsupporting

confidence: 89%

“…The coinfection rate in our study (42.9%) was higher than that previously reported in Lebanon (37%), Qatar (21.4%), and Egypt (10.8%) 18,23,24. This incongruence could be because CVEV, which was frequently detected with other viruses in our study, was not screened in the previous studies from the region 18.…”

Section: Discussioncontrasting

confidence: 86%

Viral Etiology of Acute Respiratory Infections in Pediatric Patients in Lebanon

Masoud

Hanna-Wakim

Zaraket

et al. 2019

Mediterr J Hematol Infect Dis

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BackgroundAcute respiratory infections (ARI) are the leading cause of death worldwide, especially among children. The majority of these infections in children are of viral etiology. In this study, we evaluated the incidence of viral ARI among children in Lebanon.Patients and MethodsChildren presenting with symptoms of ARI were prospectively recruited between September 2009 to February 2012. Nasopharyngeal aspirates were obtained from patients and screened for 11 respiratory viruses using a multiplex Luminex-based PCR assay.ResultsTwo hundred twenty-one patients were recruited with a median age of 1 year (IQR: 0 – 5). Out of 221 patients, 116 (52.5%) were positive for at least one virus, the majority (103/116; 88.8%) of which were in children under 6-year of age. Overall, 188 viruses were detected. Rhinovirus (RhV) was the most common virus detected in 81 (69.8%) patients followed by coxsackie virus and echovirus (CVEV) which were detected as one target in the panel in 45 (38.8%), and parainfluenza viruses (PIV types: 1, 2, 3, 4) in 24 (20.7%) patients. Coinfection with more than one virus was detected in 49 (42.9%) patients. RhV and CVEV were the most common viruses associated with co-infections and higher risk of rhinorrhea.ConclusionsViral pathogens account for at least half of the ARIs in Lebanon, with a high frequency of co-infections being detected.

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The Role of Human Metapneumovirus in Pediatric Respiratory Tract Infection in Qatar

Cited by 8 publications

References 34 publications

Viral aetiology of bronchiolitis in hospitalised children in Qatar

Viral aetiology of bronchiolitis in hospitalised children in Qatar

Human metapneumovirus in patients with respiratory tract infection in Kuwait

Viral Etiology of Acute Respiratory Infections in Pediatric Patients in Lebanon

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