The role of hyperbaric oxygen therapy in the prevention and management of radiation-induced complications of the head and neck – a systematic review of literature

Ravi, Parthsarthi; Vaishnavi, D.; Gnanam, A.; Raja, V.B. Krishnakumar

doi:10.1016/j.jormas.2017.07.005

Cited by 17 publications

(14 citation statements)

References 20 publications

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“…Once xerostomia is established, the chances to reverse it or improve it significantly are low, and all the approaches are palliative, since none of them can regenerate the salivary glands, oral mucosa, muscular fibers, and dental tissue. A few palliative techniques have been proposed including acupuncture, low power laser, electrostimulation or the use of hyperbaric oxygen, although no randomized studies have proven their effectiveness (16,(28)(29)(30).…”

Section: Dental Care For Hnc Patientsmentioning

confidence: 99%

The Multidisciplinary Team (MDT) Approach and Quality of Care

et al. 2020

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The core function of a multidisciplinary team (MDT) is to bring together a group of healthcare professionals from different fields in order to determine patients' treatment plan. Most of head and neck cancer (HNC) units are currently led by MDTs that at least include ENT and maxillofacial surgeons, radiation and medical oncologists. HNC often compromise relevant structures of the upper aerodigestive tract involving functions such as speech, swallowing and breathing, among others. The impairment of these functions can significantly impact patients' quality of life and psychosocial status, and highlights the crucial role of specialized nurses, dietitians, psycho-oncologists, social workers, and onco-geriatricians, among others. Hence, these professionals should be integrated in HNC MDTs. In addition, involving translational research teams should also be considered, as it will help reducing the existing gap between basic research and the daily clinical practice. The aim of this comprehensive review is to assess the role of the different supportive disciplines integrated in an MDT and how they help providing a better care to HNC patients during diagnosis, treatment and follow up.

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Section: Dental Care For Hnc Patientsmentioning

confidence: 99%

The Multidisciplinary Team (MDT) Approach and Quality of Care

et al. 2020

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“…The true value of HBOT appears to lie in postinjury treatment of chronic wounds or as a synergistic adjunct, rather than a solo prophylaxis agent, and a large-scale, well-structured, randomized control trial is needed to conclude whether the benefits outweigh the costs. 43 54 56 57 58…”

Section: Prophylactic Treatments Studied In Head and Neck Cancer Pati...mentioning

confidence: 99%

Noninvasive Systemic Modalities for Prevention of Head and Neck Radiation-Associated Soft Tissue Injury: A Narrative Review

Kim

Rubenstein

Chu

et al. 2022

J Reconstr Microsurg

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Background Radiation-associated soft tissue injury is a potentially devastating complication for head and neck cancer patients. The damage can range from minor sequelae such as xerostomia, which requires frequent daily maintenance, to destructive degenerative processes such as osteoradionecrosis, which can contribute to flap failure and delay or reverse oral rehabilitation. Despite the need for effective radioprotectants, the literature remains sparse, primarily focused on interventions beyond the surgeon's control, such as maintenance of good oral hygiene or modulation of radiation dose. Methods This narrative review aggregates and explores noninvasive, systemic treatment modalities for prevention or amelioration of radiation-associated soft tissue injury. Results We highlighted nine modalities with the most clinical potential, which include amifostine, melatonin, palifermin, hyperbaric oxygen therapy, photobiomodulation, pentoxifylline–tocopherol–clodronate, pravastatin, transforming growth factor-β modulators, and deferoxamine, and reviewed the benefits and limitations of each modality. Unfortunately, none of these modalities are supported by strong evidence for prophylaxis against radiation-associated soft tissue injury. Conclusion While we cannot endorse any of these nine modalities for immediate clinical use, they may prove fruitful areas for further investigation.

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“…Hyperbaric oxygen therapy (HBOT) has the ability to affect cytokine responses, induce local angiogenesis, and mobilize stem cells [ 124 , 125 ] which suggests its potential in the treatment of SG dysfunction. HBOT has been shown to improve xerostomia, the sense of taste, and the swallowing ability of patients [ 126 , 127 ]. However, most of these studies lack a sufficient sample size and appropriate control groups.…”

Section: Treatmentmentioning

confidence: 99%

“…However, most of these studies lack a sufficient sample size and appropriate control groups. The efficacy of treatment is controversial due to factors such as the placebo effect and patient adaptation to xerostomia [ 126 , 128 ]. The optimal start time of HBOT after RT and the number of treatments still need further research [ 126 , 128 ].…”

Section: Treatmentmentioning

confidence: 99%

Diagnosis, Prevention, and Treatment of Radiotherapy-Induced Xerostomia: A Review

Pang

et al. 2022

Journal of Oncology

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In patients with head and neck cancer, irradiation (IR)-sensitive salivary gland (SG) tissue is highly prone to damage during radiotherapy (RT). This leads to SG hypofunction and xerostomia. Xerostomia is defined as the subjective complaint of dry mouth, which can cause other symptoms and adversely affect the quality of life. In recent years, diagnostic techniques have constantly improved with the emergence of more reliable and valid questionnaires as well as more accurate equipment for saliva flow rate measurement and imaging methods. Preventive measures such as the antioxidant MitoTEMPO, botulinum toxin (BoNT), and growth factors have been successfully applied in animal experiments, resulting in positive outcomes. Interventions, such as the new delivery methods of pilocarpine, edible saliva substitutes, acupuncture and electrical stimulation, gene transfer, and stem cell transplantation, have shown potential to alleviate or restore xerostomia in patients. The review summarizes the existing and new diagnostic methods for xerostomia, along with current and potential strategies for reducing IR-induced damage to SG function. We also aim to provide guidance on the advantages and disadvantages of the diagnostic methods. Additionally, most prevention and treatment methods remain in the stage of animal experiments, suggesting a need for further clinical research, among which we believe that antioxidants, gene transfer, and stem cell transplantation have broad prospects.

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The role of hyperbaric oxygen therapy in the prevention and management of radiation-induced complications of the head and neck – a systematic review of literature

Cited by 17 publications

References 20 publications

The Multidisciplinary Team (MDT) Approach and Quality of Care

The Multidisciplinary Team (MDT) Approach and Quality of Care

Noninvasive Systemic Modalities for Prevention of Head and Neck Radiation-Associated Soft Tissue Injury: A Narrative Review

Diagnosis, Prevention, and Treatment of Radiotherapy-Induced Xerostomia: A Review

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