The role of IL-17 secretion in mediating the influence of stress on cancer and other human systemic diseases

Lissoni, Paolo; Messina, Giusy; Cenaj, Vezika; Rovelli, F; Porro, Giorgio; Lissoni, Arianna; Aymerich, Tiziana; Fede, Giuseppe Di

doi:10.15406/moji.2018.06.00219

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“…Then, cancer-related immune suppression would depend on both diminished immune activation, namely mediated by TH1 cells, and increased immune suppression, induced by T reg cells [8]. On the other side, the autoimmune diseases are mainly characterized by a decline in T reg cell count and activity, in association with an increased TH17 lymphocyte number, with a following enhanced IL-17 secretion [9], while the behavior of TH1 lymphocytes is still controversial, as well as that of total lymphocyte…”

Section: Introductionmentioning

confidence: 99%

The Negative Prognostic Significance of Low Lymphocyte-To-Monocyte Ratio (LMR) in Both Advancer Cancer and in the Acute Phase of the Autoimmune Diseases: How to Explain the Same Significance in Pathologies Characterized by an Opposite Immune Status?

Lissoni¹,

Messina²,

Tosatto³

et al. 2020

BJSTR

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The recent clinical studies performed to in vivo investigate the immune functions have shown that lymphocyte-to-monocyte ratio (LMR) may be considered as the more simple and synthetic biomarker to clinically analyze the immune status of patients, since the immune activation is mainly related to lymphocyte functions, whereas the monocyte-macrophage system is the main responsible for chronic inflammationrelated immune suppression. Cancer progression has been proven to be associated with a progressive decline in LMR values, while the behavior of LMR in autoimmunity is more controversial. The present preliminary study was planned to analyze LMR values in cancer patients, and in patients with autoimmune diseases in relation to the different disease phases. The study included 149 cancer patients (non-metastatic disease: 68; metastatic disease: 81), 51 patients with autoimmune pathologies (remission phase: 37; acute phase: 14), and in 100 healthy subjects as controls. LMR mean values observed in metastatic patients were significantly lower than those found either in patients without metastases, or in controls. Patients with autoimmune diseases in remission phases showed higher values of LMR than controls, without, however, significant differences, whereas LMR mean values observed in patients during the acute phase of disease were significantly lower with respect to both controls and patients in remission phase. These results seem to suggest that the evidence of abnormally low values of LMR may deserve a negative prognostic significance in both cancer and autoimmunity. This paradoxical evidence may be explained only by investigating the main inflammatory and anti-inflammatory cytokines responsible for the regulation of the immune functions, including TGF-beta, IL-2, IL-17, IL-6, and IL-12, whose detection will be the aim of future clinical studies.

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Section: Introductionmentioning

confidence: 99%