The role of liposomes in analytical processes

Gómez‐Hens, A.; Fernández-Romero, J.M.

doi:10.1016/j.trac.2004.07.017

Cited by 117 publications

(79 citation statements)

References 92 publications

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“…Based on the number of bilayers and vesicles, the liposomes are classified as ULVs (25 nm to 1 mm), or multi-lamellar vesicles (MLVs, 0.1-15 mm), or multi-vesicular vesicles (MVVs, 1.6-10.5 mm). Furthermore, based on their size, unilamellar liposomes are classified as large unilamellar vesicles (LUVs, 100 nm to 1 mm) and small unilamellar vesicles (SUVs, 25-50 nm) (figure 9) [18].…”

Section: Classificationmentioning

confidence: 99%

Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

327

217

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Liposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imaging, applications in cosmetics and tissue engineering. Tissue engineering is defined as a strategy for promoting the regeneration of tissues for the human body. This strategy may involve the coordinated application of defined cell types with structured biomaterial scaffolds to produce living structures. To create a new tissue, based on this strategy, a controlled stimulation of cultured cells is needed, through a systematic combination of bioactive agents and mechanical signals. In this review, we highlight the potential role of liposomes as a platform for the sustained and local delivery of bioactive agents for tissue engineering and regenerative medicine approaches.

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Section: Classificationmentioning

confidence: 99%

Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

327

217

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“…The wrapping of a particle by a fluid membrane is a phenomenon of widespread and generic interest in biology [1][2][3][4] as well as in a variety of technological applications such as drug delivery, [5][6][7][8][9][10][11][12] gene delivery, 13,14 and the design of nanoreactors [15][16][17][18][19][20][21][22][23][24] which would allow for highly controllable reaction conditions.…”

Section: Introductionmentioning

confidence: 99%

Kinetics of particle wrapping by a vesicle

Mirigian

Muthukumar

2013

The Journal of Chemical Physics

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We present theoretical results on kinetics for the passive wrapping of a single, rigid particle by a flexible membrane. Using a simple geometric ansatz for the shape of the membrane/particle complex we first compute free energy profiles as a function of the particle size, attraction strength between the particle and vesicle, and material properties of the vesicle-bending stiffness and stretching modulus. The free energy profiles thus computed are taken as input to a stochastic model of the wrapping process, described by a Fokker-Planck equation. We compute average uptake rates of the particle into the vesicle. We find that the rate of particle uptake falls to zero outside of a thermodynamically allowed range of particle sizes. Within the thermodynamically allowed range of particle size, the rate of uptake is variable and we compute the optimal particle size and maximal uptake rate as a function of the attraction strength, the vesicle size, and vesicle material properties. © 2013 AIP Publishing LLC. [http://dx

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“…According to the structure, liposomes can be classified as multilamellar vesicles, small unilamellar vesicles, large unilamellar vesicles (LUVs), giant unilamellar vesicles and multivesicular vesicles. The application of liposomes in various analytical processes such as liquid chromatography, capillary electrophoresis (CE), immunoassays and sensors has been reviewed previously (Gómez-Hens and Fernández-Romero, 2004;Edwards and Baeumner, 2006).…”

Section: Introductionmentioning

confidence: 99%

Liposomes in chromatography

Cserháti

Szőgyi

2010

Biomedical Chromatography

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The newest achievements in the application of liposomes in different chromatographic technologies such as high-performance liquid chromatography and electrically driven separation methods was compiled and critically evaluated. The employment of chromatographic methodologies for the determination of molecular parameters of biological importance is also discussed in detail. The future trends of the use of liposomes is also shortly discussed.

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The role of liposomes in analytical processes

Cited by 117 publications

References 92 publications

Liposomes in tissue engineering and regenerative medicine

Liposomes in tissue engineering and regenerative medicine

Kinetics of particle wrapping by a vesicle

Liposomes in chromatography

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