The role of long non-coding RNAs in the development of adipose cells

Sufianov, Albert; Beilerli, Aferin; Kudriashov, Valentin; Ilyasova, Tatiana; Liang, Yanchao; Mukhamedzyanov, Albert; Bessonova, Marina; Mashkin, Andrey; Beylerli, Ozal

doi:10.1016/j.ncrna.2023.02.009

Cited by 6 publications

(3 citation statements)

References 82 publications

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“…Furthermore, LncRNAs can recruit proteins as well as RNA from either the nucleus or the cytoplasm to form functional complexes. (Quinn & Chang, 2016) (Sufianov et al, 2023). Numerous cellular and carcinogenesis processes are mediated by lncRNAs, including transcriptional regulators, tumorigenesis, cell migration, and invasion (Beermann et al, 2016) (Yangjun Wu et al, 2019) (Loganathan & Doss C, 2023).…”

Section: Functional Identification Of Long Non-coding Rnasmentioning

confidence: 99%

Correlation Between Long non-coding RNA SOX2OT rs9839776 C>T Polymorphism and Unexplained Recurrent Miscarriages

Abd Ellatif,

Agwa,

Ashaat

et al. 2024

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Recurrent miscarriage (RM) is a severe pregnancy complication that results in the loss of two or more spontaneous pregnancies. RM has several complex reasons. Advances in genetics, immunology, and cell biology have strongly connected non-coding RNAs (ncRNAs) to recurrent miscarriages. NcRNAs regulate placental trophoblast cell processes, which affect trophoblast development, migration, and invagination; they also have a role in breast and ovarian cancer. As a result, their abnormal expression may contribute to the progression of RM. Several investigations have found a connection between RM and genetic polymorphisms that regulate cell migration. Variations in the long non-coding RNA (lncRNA) SOX2OT gene have been associated with a variety of cancer-related illnesses, particularly colorectal cancer, breast cancer, and cancer of the digestive tract. According to a recent study, the long non-coding SOX2OT rs9839776 CT raises the risk of RM. In this review, we explain the existing evidence supporting a relationship between the LncRNA SOX2OT rs9839776 polymorphisms and recurrent miscarriages.

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Section: Functional Identification Of Long Non-coding Rnasmentioning

confidence: 99%

Correlation Between Long non-coding RNA SOX2OT rs9839776 C>T Polymorphism and Unexplained Recurrent Miscarriages

Abd Ellatif,

Agwa,

Ashaat

et al. 2024

Egyptian Academic Journal of Biological Sciences. C, Physiology

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show abstract

“…These lncRNAs serve as critical intermediaries in transmitting information from higher-order chromosomal interactions to modifications in chromatin structure. They have the potential to orchestrate the organization of chromatin domains, facilitating the long-distance activation of specific genes [ 20 ]. Moreover, it's a recurring theme observed in various model systems that lncRNAs form intricate networks of ribonucleoprotein (RNP) complexes, collaborating with numerous chromatin regulators to direct their enzymatic activities to precise locations within the genome.…”

Section: Introductionmentioning

confidence: 99%

The role of lncRNA-mediated ceRNA regulatory networks in liver fibrosis

Jiang,

Gareev,

Ilyasova

et al. 2024

Non-coding RNA Research

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“…While each SNP individually exerts a modest effect on obesity risk, their collective impact is substantially more pronounced [6]. Modern genomic technologies have unveiled that the complexity of the human genome interplay in relation to obesity is greater than previously recognized, highlighting that sequence variations, including those in non-protein coding regions of DNA, and they are reshaping our comprehension of the genome's role in obesity [7]. While certain genetic variants have been identified as predictors of susceptibility to obesity, it is becoming increasingly clear that obesity, like many other complex conditions, is characterized by a multifaceted genetic signature.…”

Section: Introductionmentioning

confidence: 99%

Deciphering the Interplay between Genetic Risk Scores and Lifestyle Factors on Individual Obesity Predisposition

Chermon,

Birk

2024

Nutrients

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Obesity’s variability is significantly influenced by the interplay between genetic and environmental factors. We aimed to integrate the combined impact of genetic risk score (GRSBMI) with physical activity (PA), sugar-sweetened beverages (SSB), wine intake, and eating habits score (EHS) on obesity predisposition risk. Adults’ (n = 5824) data were analyzed for common obesity-related single nucleotide polymorphisms and lifestyle habits. The weighted GRSBMI was constructed and categorized into quartiles (Qs), and the adjusted multivariate logistic regression models examined the association of GRSBMI with obesity (BMI ≥ 30) and lifestyle factors. GRSBMI was significantly associated with obesity risk. Each GRSBMI unit was associated with an increase of 3.06 BMI units (p ≤ 0.0001). PA markedly reduced obesity risk across GRSBMI Qs. Inactive participants’ (≥90 min/week) mean BMI was higher in GRSBMI Q3–Q4 compared to Q1 (p = 0.003 and p < 0.001, respectively). Scoring EHS ≥ median, SSBs (≥1 cup/day), and non-wine drinking were associated with higher BMI within all GRSBMI Qs compared to EHS < median, non-SSBs, and non-wine drinkers. Mean BMI was higher in GRSBMI Q4 compared to other quartiles (p < 0.0001) in non-wine drinkers and compared to Q1 for SSB’s consumers (p = 0.07). A higher GRSBMI augmented the impact of lifestyle factors on obesity. The interplay between GRSBMI and modifiable lifestyle factors provides a tailored personalized prevention and treatment for obesity management.

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The role of long non-coding RNAs in the development of adipose cells

Cited by 6 publications

References 82 publications

Correlation Between Long non-coding RNA SOX2OT rs9839776 C>T Polymorphism and Unexplained Recurrent Miscarriages

Correlation Between Long non-coding RNA SOX2OT rs9839776 C>T Polymorphism and Unexplained Recurrent Miscarriages

The role of lncRNA-mediated ceRNA regulatory networks in liver fibrosis

Deciphering the Interplay between Genetic Risk Scores and Lifestyle Factors on Individual Obesity Predisposition

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