The role of long noncoding RNA HOTAIR in the acquired multidrug resistance to imatinib in chronic myeloid leukemia cells

Wang, Haiying; Li, Qian; Tang, Shusen; Li, Meifang; Feng, Anhua; Qin, Linling; Liu, Zhiqiang; Wang, Xin

doi:10.1080/10245332.2016.1258152

Cited by 68 publications

(45 citation statements)

References 36 publications

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“…Next, we detected several known lncRNAs involved in drug resistance in K562 and K562/ADM cells by qRT-PCR, such as HOTAIR [28], PVT1 [29], H19 [10], MALAT1 [30], UCA1 [11], CCAL [31], ANRIL [32], MEG3 [33] and FENDRR [12]. Interestingly, we found that FENDRR was mostly downregulated in K562/ADM cells compared with that in K562 cells ( Fig.…”

Section: Lncrna Fendrr Level Was Downregulated In Adriamycin-resistanmentioning

confidence: 86%

LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR‐184 in chronic myelogenous leukaemia cells

Zhang

Li³

et al. 2019

FEBS Letters

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Chemotherapy is a major anticancer therapeutic modality, however, multidrug resistance (MDR) is frequently observed and hinders treatment efficacy. Here, we investigated the role and potential mechanism of the long noncoding RNA (lncRNA) FENDRR in adriamycin resistance of chronic myeloid leukaemia (CML) cells. FENDRR overexpression attenuates adriamycin resistance, as shown by increased Rhodamine 123 accumulation, promotion of cell apoptosis in vitro and suppression of tumour growth in vivo. Mechanistically, we identified that FENDRR reduces the interaction of the RNA‐binding protein HuR with MDR1 via acting as a sponge, and miR‐184 competitively binds to FENDRR with HuR. Thus, the HuR/FENDRR/miR‐184 interaction contributes to MDR1 activity. These findings indicate that FENDRR is a potential target for reversing adriamycin resistance.

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Section: Lncrna Fendrr Level Was Downregulated In Adriamycin-resistanmentioning

confidence: 86%

LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR‐184 in chronic myelogenous leukaemia cells

Zhang

Li³

et al. 2019

FEBS Letters

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“…In addition, activation of the PI3K/ Akt signaling pathway was markedly reduced when the HOTAIR gene was silenced in K562-imatinib cells. These findings indicate that knockdown of HOTAIR played a crucial role in improving acquired resistance to imatinib in CML K562-R cells via the PI3K/Akt pathway [146]. Overall, although HOTAIR was involved in the development and progression of this type of malignancy and was associated with a poor clinical-pathologic prognostic stratification, the exact function and mechanism have yet to be elucidated.…”

Section: Hotair In Diffuse Large B-cell Lymphoma and Chronic Myelogenmentioning

confidence: 93%

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

Tang

Hann

2018

Cell Physiol Biochem

219

135

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Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that are longer than 200 nucleotides without protein-coding potential and function as novel master regulators in various human diseases, including cancer. Accumulating evidence shows that lncRNAs are dysregulated and implicated in various aspects of cellular homeostasis, such as proliferation, apoptosis, mobility, invasion, metastasis, chromatin remodeling, gene transcription, and post-transcriptional processing. However, the mechanisms by which lncRNAs regulate various biological functions in human diseases have yet to be determined. HOX antisense intergenic RNA (HOTAIR) is a recently discovered lncRNA and plays a critical role in various areas of cancer, such as proliferation, survival, migration, drug resistance, and genomic stability. In this review, we briefly introduce the concept, identification, and biological functions of HOTAIR. We then describe the involvement of HOTAIR that has been associated with tumorigenesis, growth, invasion, cancer stem cell differentiation, metastasis, and drug resistance in cancer. We also discuss emerging insights into the role of HOTAIR as potential biomarkers and therapeutic targets for novel treatment paradigms in cancer.

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“…Whole cell lysates were prepared in RIPA buffer containing protease inhibitors and western blotting was performed as described previously . Protein concentrations were measured using a protein assay kit (Pierce, Thermal Fisher, Rockford, IL, USA).…”

Section: Methodsmentioning

confidence: 99%

Inhibition of BRD4 attenuates cardiomyocyte apoptosis via NF‐κB pathway in a rat model of myocardial infarction

Sun

Xie

et al. 2018

Cardiovascular Therapeutics

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The role of long noncoding RNA HOTAIR in the acquired multidrug resistance to imatinib in chronic myeloid leukemia cells

Abstract: LncRNA HOTAIR modulates CML cell MDR in a PI3K/Akt-dependent way.

Cited by 68 publications

References 36 publications

LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR‐184 in chronic myelogenous leukaemia cells

LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR‐184 in chronic myelogenous leukaemia cells

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

Inhibition of BRD4 attenuates cardiomyocyte apoptosis via NF‐κB pathway in a rat model of myocardial infarction

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