2023
DOI: 10.1111/jog.15791
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The role of mitochondrial dynamics in the pathophysiology of endometriosis

Hiroshi Kobayashi,
Sho Matsubara,
Chiharu Yoshimoto
et al.

Abstract: AimEndometriosis is a chronic disease of reproductive age, associated with pelvic pain and infertility. Endometriotic cells adapt to changing environments such as oxidative stress and hypoxia in order to survive. However, the underlying mechanisms remain to be fully elucidated. In this review, we summarize our current understanding of the pathogenesis of endometriosis, focusing primarily on the molecular basis of energy metabolism, redox homeostasis, and mitochondrial function, and discuss perspectives on futu… Show more

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Cited by 9 publications
(2 citation statements)
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“…Finally, altered mitophagy-apoptosis axis may be associated not only with PCOS but also with various pathological conditions such as endometriosis and ovarian cancer. [123][124][125] Women with PCOS and endometriosis are characterized by poor oocyte quality, lower fertilization rate, and delayed embryonic development through impaired mitochondrial function. 6,7,126 Furthermore, mitochondrial dysfunction has also been implicated in type 2 diabetes, cardiovascular disease, and aging.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, altered mitophagy-apoptosis axis may be associated not only with PCOS but also with various pathological conditions such as endometriosis and ovarian cancer. [123][124][125] Women with PCOS and endometriosis are characterized by poor oocyte quality, lower fertilization rate, and delayed embryonic development through impaired mitochondrial function. 6,7,126 Furthermore, mitochondrial dysfunction has also been implicated in type 2 diabetes, cardiovascular disease, and aging.…”
Section: Discussionmentioning
confidence: 99%
“…Mitochondria are the organelles that produce the energy required to sustain cellular activity by constantly undergoing repeated cycles of fusion and division ( Ye et al, 2023 ). Mitochondrial dysfunction and reduced energy metabolism have been reported in granulosa and ectopic endometrial cells of patients with EMs ( Hsu et al, 2015 ; Kobayashi et al, 2023 ), and the altered mitochondrial dynamics and morphology increase the survivability of ectopic endometrial cells in hypoxic and oxidative-stress-related environments, thereby facilitating EMS progression ( Ye et al, 2023 ). Oxidative stress is defined as an imbalance between oxidants, such as reactive oxygen species (ROS), and antioxidants, such as the enzyme superoxide dismutase (SOD).…”
Section: Possible Associations Of Adiponectin With the Pathogenesis O...mentioning
confidence: 99%