The role of mood stabilisers in the treatment of the depressive facet of bipolar disorders

Bourin, Michel; Prica, Corina

doi:10.1016/j.neubiorev.2007.03.001

Cited by 22 publications

(16 citation statements)

References 121 publications

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“…Among the common anticonvulsants, lamotrigine [3,5-diamino-6(2,3-dichlorophenyl)-1,2,4-triazine] is used in the management of generalized and partial seizures [4,50]. It is also reported that lamotrigine improves the manifests of bipolar depression and mania [9,27]. Also, this anticonvulsant agent has been shown to possess therapeutic benefits in monotherapy as well as an adjunct treatment for management of bipolar depression [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…It is also reported that lamotrigine improves the manifests of bipolar depression and mania [9,27]. Also, this anticonvulsant agent has been shown to possess therapeutic benefits in monotherapy as well as an adjunct treatment for management of bipolar depression [8][9][10]. Randomized clinical trials have revealed that lamotrigine is an advantageous medicine in treatment of patients with bipolar disorder suffer from episodes of major depression [13].…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological evidence for the involvement of the NMDA receptor and nitric oxide pathway in the antidepressant-like effect of lamotrigine in the mouse forced swimming test

Ostadhadi

Ahangari

Nikoui

et al. 2016

Biomedicine & Pharmacotherapy

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmacological evidence for the involvement of the NMDA receptor and nitric oxide pathway in the antidepressant-like effect of lamotrigine in the mouse forced swimming test

Ostadhadi

Ahangari

Nikoui

et al. 2016

Biomedicine & Pharmacotherapy

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“…Despite the availability of a variety of mood stabilizers, treatment of the depressive phase remains challenging because many conventional antidepressants precipitate the onset of the manic phase (Bourin & Prica, 2007). In search of solutions to this dilemma, an anticonvulsant lamotrigine has emerged as a promising candidate.…”

Section: Introductionmentioning

confidence: 99%

Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine

Zhang

et al. 2010

Int. J. Neuropsychopharm.

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The anticonvulsant drug lamotrigine has been shown to produce antidepressant effects in patients with bipolar disorder. To date, only a few preclinical studies have been conducted using lamotrigine treatment in the forced swim test (FST), an animal model of depression with low face validity. The underlying mechanisms by which lamotrigine works have not been well characterized either. This study extends earlier work on the role of brain-derived neurotrophic factor (BDNF) in regulating the antidepressant actions of lamotrigine. We showed that in rats subjected to chronic unpredictable stress, chronic administration of 30 mg/kg lamotrigine ameliorates behavioural deficits of stressed rats in both sucrose preference test (SPT) and novelty-suppressed feeding test (NSFT). In parallel, chronic lamotrigine treatment up-regulates frontal and hippocampal BDNF protein expression in both naive and stressed animals, and restores the stress-induced down-regulation of BDNF levels. In addition, inhibition of BDNF signalling by infusion of K252a, an inhibitor of the BDNF receptor TrkB, blocks the antidepressant effects of lamotrigine in SPT, NSFT and FST. Taken together, this study provides further evidence that BDNF is an essential mediator for the antidepressant effects of lamotrigine.

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“…Így például az imént HDACinhibitorként bemutatott valpronsavat bipoláris betegek kezelésére régóta használják [42]. Egy másik, biciklikus antidepresszáns -amellett, hogy szelektív szerotoninvisszavétel-gátló -indukálja az egyik HDAC enzim kifejeződését is és lecsökkenti a H3 hiszton menynyiségét az érintett agyterületeken [43].…”

Section: úJ Terápiás Megközelítésekunclassified

Beyond genetics – The emerging role of epigenetics and its clinical aspects

et al. 2012

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Az utóbbi évtizedben világossá vált, hogy a génekben kódolt információ fajok közötti eltérése nem lehet egyedül meghatározó forrása az élőlények sokféleségének. Az egyedfejlődés során a sejtvonalak térben és időben egyedi mó-don bekövetkező fenotípus-változásainak hátterében álló dinamikus tényezőknek mindössze egy eleme a genetikai kód maga. A sejt és az egész szervezet jellemzőinek kialakításában és fenntartásában tehát nagyobb szerepe van a környezet által kialakított génaktivitás-változásoknak, mint azt korábban gondoltuk. Az epigenom a kromatinra kerülő molekuláris jelzéseken keresztül közvetít a genom és a környezet között. Ezeket a különböző jelzéseket kutatják az epigenetika gyorsan fejlődő területei. A jelzések sejtciklusról sejtciklusra átkerülhetnek az utódsejtekbe, de akár generációkat átívelő módon is öröklődhetnek. Az epimutációk -az epigenom rendellenes megváltozásai -döntő szerepet játszhatnak olyan komplex emberi betegségek kialakulásában is, mint a rák. Az epigenetika jelentheti a hiányzó láncszemet a genetika, a környezet és a betegségek között, ezáltal jelentős hatással bírhat a jövő gyógyszer-fejlesztésére és új terápiás/prevenciós megközelítéseket tehet lehetővé. Orv. Hetil., 2012, 153, 214-221. Kulcsszavak: epigenetika, citozinmetiláció, hisztonmodifi kációk, epimutációk, epigenetikus gyógyszerek Beyond genetics -The emerging role of epigenetics and its clinical aspectsAnalysis of genomic sequences has clearly shown that the genomic differences among species do not explain the diversity of life. The genetic code itself serves as only a part of the dynamic complexity that results in the temporal and spatial changes in cell phenotypes during development. It has been concluded that the phenotype of a cell and of the organism as a whole is more infl uenced by environmentally-induced changes in gene activity than had been previously thought. The emerging fi eld of epigenetics focuses on molecular marks on chromatin; called the epigenome, which serve as transmitters between the genome and the environment. These changes not only persist through multiple cell division cycles, but may also endure for multiple generations. Irregular alterations of the epigenome; called epimutations, may have a decisive role in the etiology of human pathologies such as malignancies and other complex human diseases. Epigenetics can provide the missing link between genetics, disease and the environment. Therefore, this fi eld may have an increasing impact on future drug design and serve as a basis for new therapeutic/preventative approaches. Orv. Hetil., 2012, 153, 214-221. Keywords: epigenetics, cytosine methylation, histone modifi cations, epimutations, epigenetic drugs (Beérkezett: 2011. december 6.; elfogadva: 2011. december 22.) Rövidítések CpG = citozin-guanin dinukleotid; DNMT = DNS-metiltranszferáz; EWAS = epigenome-wide association studies; GWAS = genom-wide association studies; HAT = hisztonacetiltranszferáz; HDAC = hiszton-deacetiláz; HMT = hiszton-metiltranszferáz; nkRNS = nem kódoló RNS A genomiális ...

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The role of mood stabilisers in the treatment of the depressive facet of bipolar disorders

Cited by 22 publications

References 121 publications

Pharmacological evidence for the involvement of the NMDA receptor and nitric oxide pathway in the antidepressant-like effect of lamotrigine in the mouse forced swimming test

Pharmacological evidence for the involvement of the NMDA receptor and nitric oxide pathway in the antidepressant-like effect of lamotrigine in the mouse forced swimming test

Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine

Beyond genetics – The emerging role of epigenetics and its clinical aspects

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