The Role of Osteokines in Sarcopenia: Therapeutic Directions and Application Prospects

Lu, Wenhao; Xiao, Wenfeng; Xie, Wenqing; Fu, Xin; Pan, Linyuan; Jin, Hongfu; Yu, Yongle; Zhang, Yi; Li, Yusheng

doi:10.3389/fcell.2021.735374

Cited by 19 publications

(26 citation statements)

References 163 publications

(195 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meanwhile, treatments for atherosclerosis such as angiotensin receptor blockers improve bone strength [140]. These results partly suggest that risk factors are shared among atherosclerosis, osteoporosis, and sarcopenia and indicate that an integrated approach to the whole system may be effective for prevention of these disease conditions [141,142]. One of the promising therapeutic approaches may be nutritional support with exercise, as described previously (143,144).…”

Section: The Concept Of a Blood Vessel/heart-boneskeletal Muscle Axis...mentioning

confidence: 78%

Emerging cross-talks between chronic kidney disease–mineral and bone disorder (CKD–MBD) and malnutrition–inflammation complex syndrome (MICS) in patients receiving dialysis

et al. 2022

View full text Add to dashboard Cite

Chronic kidney disease–mineral and bone disorder (CKD–MBD) is a systemic disorder that affects multiple organs and systems and increases the risk of morbidity and mortality in patients with CKD, especially those receiving dialysis therapy. CKD–MBD is highly prevalent in CKD patients, and its treatment is gaining attention from healthcare providers who manage these patients. Additional important pathologies often observed in CKD patients are chronic inflammation and malnutrition/protein-energy wasting (PEW). These two pathologies coexist to form a vicious cycle that accelerates the progression of various other pathologies in CKD patients. This concept is integrated into the term “malnutrition–inflammation–atherosclerosis syndrome” or “malnutrition–inflammation complex syndrome (MICS)”. Recent basic and clinical studies have shown that CKD–MBD directly induces inflammation as well as malnutrition/PEW. Indeed, higher circulating levels of inorganic phosphate, fibroblast growth factor 23, parathyroid hormone, and calciprotein particles, as markers for critical components and effectors of CKD–MBD, were shown to directly induce inflammatory responses, thereby leading to malnutrition/PEW, cardiovascular diseases, and clinically relevant complications. In this short review, we discuss the close interplay between CKD–MBD and MICS and emphasize the significance of simultaneous control of these two seemingly distinct pathologies in patients with CKD, especially those receiving dialysis therapy, for better management of the CKD/hemodialysis population.

show abstract

Section: The Concept Of a Blood Vessel/heart-boneskeletal Muscle Axis...mentioning

confidence: 78%

Emerging cross-talks between chronic kidney disease–mineral and bone disorder (CKD–MBD) and malnutrition–inflammation complex syndrome (MICS) in patients receiving dialysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…[225] Receptor activator of NF-κB ligand RANKL Inhibits muscle mass and function. [181] Wnt family member 3a Wnt3a Wnt3a accelerates C2C12 differentiation. [220] Prostaglandin E2 PGE2 Mimics specific effects of the osteocyte-secreted factors on the process of myogenesis and also the muscle function.…”

Section: Undercarboxylated Osteocalcin Ucocnmentioning

confidence: 99%

“…As previously described, OCN is the most abundant noncollagen protein secreted in a carboxylated form solely in osteoblasts. Because of its low pH and decarboxylation, it may be released into the blood circulation [ 181 ]. OCN also stimulates the synthesis of IL-6 [ 210 ].…”

Section: Musculoskeletal Crosstalkmentioning

confidence: 99%

Dissociation of Bone Resorption and Formation in Spaceflight and Simulated Microgravity: Potential Role of Myokines and Osteokines?

2022

View full text Add to dashboard Cite

The dissociation of bone formation and resorption is an important physiological process during spaceflight. It also occurs during local skeletal unloading or immobilization, such as in people with neuromuscular disorders or those who are on bed rest. Under these conditions, the physiological systems of the human body are perturbed down to the cellular level. Through the absence of mechanical stimuli, the musculoskeletal system and, predominantly, the postural skeletal muscles are largely affected. Despite in-flight exercise countermeasures, muscle wasting and bone loss occur, which are associated with spaceflight duration. Nevertheless, countermeasures can be effective, especially by preventing muscle wasting to rescue both postural and dynamic as well as muscle performance. Thus far, it is largely unknown how changes in bone microarchitecture evolve over the long term in the absence of a gravity vector and whether bone loss incurred in space or following the return to the Earth fully recovers or partly persists. In this review, we highlight the different mechanisms and factors that regulate the humoral crosstalk between the muscle and the bone. Further we focus on the interplay between currently known myokines and osteokines and their mutual regulation.

show abstract

“…A low OPG/RANKL ratio is present in patients with RA compared to healthy patients and is associated with increased radiographic damage and joint and bone destruction in RA. In this sense, the RANKL/OPG relationship plays an essential role in regulating bone homeostasis in RA, and changes in this relationship may be a protective mechanism against accelerated bone loss in RA [ 47 , 51 , 52 , 53 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ].…”

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

“…Age, stage of the disease, and several other factors influence the levels of OPG, justifying such discrepant results between studies. Furthermore, autoantibodies to osteoprotegerin are associated with increased bone resorption in RA, with OPG antibody-positive patients having longer disease duration and activity and higher levels of bone resorption markers [ 66 , 67 , 70 , 71 , 72 ].…”

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

Organokines in Rheumatoid Arthritis: A Critical Review

Laurindo

Maio

Barbalho

et al. 2022

IJMS

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects the joints. Organokines can produce beneficial or harmful effects in this condition. Among RA patients, organokines have been associated with increased inflammation and cartilage degradation due to augmented cytokines and metalloproteinases production, respectively. This study aimed to perform a review to investigate the role of adipokines, osteokines, myokines, and hepatokines on RA progression. PubMed, Embase, Google Scholar, and Cochrane were searched, and 18 studies were selected, comprising more than 17,000 RA patients. Changes in the pattern of organokines secretion were identified, and these could directly or indirectly contribute to aggravating RA, promoting articular alterations, and predicting the disease activity. In addition, organokines have been implicated in higher radiographic damage, immune dysregulation, and angiogenesis. These can also act as RA potent regulators of cells proliferation, differentiation, and apoptosis, controlling osteoclasts, chondrocytes, and fibroblasts as well as immune cells chemotaxis to RA sites. Although much is already known, much more is still unknown, principally about the roles of organokines in the occurrence of RA extra-articular manifestations.

show abstract

The Role of Osteokines in Sarcopenia: Therapeutic Directions and Application Prospects

Cited by 19 publications

References 163 publications

Emerging cross-talks between chronic kidney disease–mineral and bone disorder (CKD–MBD) and malnutrition–inflammation complex syndrome (MICS) in patients receiving dialysis

Emerging cross-talks between chronic kidney disease–mineral and bone disorder (CKD–MBD) and malnutrition–inflammation complex syndrome (MICS) in patients receiving dialysis

Dissociation of Bone Resorption and Formation in Spaceflight and Simulated Microgravity: Potential Role of Myokines and Osteokines?

Organokines in Rheumatoid Arthritis: A Critical Review

Contact Info

Product

Resources

About